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Naringenin

Naringenin structure

CAS No.: 480-41-1

Chemical Name:: Naringenin

Synonyms: NARIGENIN;5,7-DIHYDROXY-2-(4-HYDROXYPHENYL)CHROMAN-4-ONE;naringenine;(s)-naringenin;(2S)-Naringenin;ringenin;5,7-Dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one;NSC 11855;NSC 34875;salipurol

CBNumber:: CB5325311

Molecular Formula:: C15H12O5

Molecular Weight:: 272.25

MDL Number:: MFCD00870553

MOL File:: 480-41-1.mol

Last updated:2024-04-21 09:47:59

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Naringenin Properties

Melting point	247-250 °C(lit.)
Boiling point	335.31°C (rough estimate)
Density	1.2066 (rough estimate)
refractive index	1.6000 (estimate)
FEMA	4797 \| (+/-)-NARINGENIN
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
pka	7.52±0.40(Predicted)
form	Powder
color	Beige-brown
InChI	InChI=1S/C15H12O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2/t13-/m0/s1
InChIKey	FTVWIRXFELQLPI-ZDUSSCGKSA-N
SMILES	[C@H]1(C2=CC=C(O)C=C2)OC2=CC(O)=CC(O)=C2C(=O)C1
LogP	2.520
CAS DataBase Reference	480-41-1(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	HN5425SBF2
EPA Substance Registry System	4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-, (2S)- (480-41-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Hazard Codes	Xi,Xn
Risk Statements	36/37/38-22
Safety Statements	26-36-37/39
WGK Germany	3
HazardClass	IRRITANT
HS Code	29329990

Naringenin price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	300666	Naringenin	480-41-1	20mg	$263	2021-12-16	Buy
Usbiological	N0208	Naringenin	480-41-1	10g	$403	2021-12-16	Buy
TRC	N378955	(S)-Naringenin	480-41-1	50mg	$700	2021-12-16	Buy
Biorbyt Ltd	orb105705	Naringenin >98%,Standard References Grade	480-41-1	20mg	$569.5	2021-12-16	Buy
Medical Isotopes, Inc.	52478	(S)-Naringenin	480-41-1	10g	$650	2021-12-16	Buy

Product number	Packaging	Price	Buy
300666	20mg	$263	Buy
N0208	10g	$403	Buy
N378955	50mg	$700	Buy
orb105705	20mg	$569.5	Buy
52478	10g	$650	Buy

Naringenin Chemical Properties,Uses,Production

Pharmacological effects

Naringenin is the aglycone of naringin, it belongs to dihydro-flavonoids, at room temperature it is a white needle crystal(methanol), soluble in alcohol, ether and benzene, almost insoluble in water. In HCl-Mg powder reaction,it is cherry red ,in sodium borohydride reaction it is red purple, in molish reaction,it is negative. In the nature, it is mainly from the Rosaceae cherry (Prunus yedoensis Mate.) bud,and sumac plants (Amacardi-um occidentale L.) fruits’ core-shell.
Nucleus structure is similar among flavonoids, most of the components do not have ideal fat-soluble and water-soluble abilities, the bioavailability is low. By modifying its structure, the introduction of strongly fat-soluble or water-soluble groups can increase its fat-soluble or water-soluble abilities, thus improving the bioavailability. The structure modification includes alkylation, acylation, sulfonation,glycosidation of hydroxyl groups and the formation of the metal complex.
The effects of naringenin including: anti-bacterial, anti-inflammatory, antioxidant, cough expectorant,decreasing blood fat, anti-cancer and anti-tumor, antispasmodic, scavenging free radicals, prevention and treatment of liver disease, inhibition of platelet aggregation, anti-atherosclerosis and others , which can be widely used in medicine, food and other fields.
1. Antibacterial: it has a strong antibacterial effect on Staphylococcus aureus, Escherichia coli, Shigella dysenteriae, and Salmonella typhi. Naringenin also has effect on fungi , 1000ppm is sprayed onto the rice, blast fungus infection can be reduced 40-90%,and it is not toxic to livestock and humans.
2. Anti-inflammatory: intraperitoneal injection of 20mg/kg per day for rats can inhibit the inflammatory process which caused by wool ball implantation.
3. Anticancer: it displays action in L1210 leukemia and sarcomas in rats.
4. Antispasmodic and gallbladder: among the flavonoids,it has stronger effects. Naringenin has a strong effect on increasing bile secretion in experimental animals.

Application

It has anti-bacterial, anti-inflammatory, anti-cancer, antispasmodic and choleretic effects.

Chemical Properties

beige-brown powder

Uses

The aglucon of Naringin. Inhibitory mechanism of Naringenin against carcinogenic acrylamide formation and nonenzymic browning in Maillard model reactions

Uses

antiulcer, antioxidant, immunomodulator, cholesterol lowering

Uses

(S)-Naringenin, an active flavanone, maintains antioxidative, anti-inflammatory and antitumorigenic activities. Used in the treatment of praquat (PQ)-induced oxidative stress.

Definition

ChEBI: (S)-naringenin is the (S)-enantiomer of naringenin. It has a role as an expectorant and a plant metabolite. It is a naringenin and a (2S)-flavan-4-one. It is a conjugate acid of a (S)-naringenin(1-). It is an enantiomer of a (R)-naringenin.

Purification Methods

Crystallise it from EtOH or aqueous EtOH. It has UV: at 290nm (EtOH). The S(-)-enantiomer (natural form) has m 255-256o (from EtOH) and [] D -28.0o (c 2, EtOH), [] D -35.2o (c 1, pyridine).

Naringenin Preparation Products And Raw materials

Raw materials

Preparation Products

2,3-Dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-(phenylmethoxy)-4H-1-benzopyran-4-one

Naringenin Suppliers

Global( 452)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chongqing Zhihe Biopharmaceutical Co., Ltd.	+86-18580541567 +86-17782035140	sales@zhswyy.com	China	338	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+86-13474506593 +86-13474506593	sarah@tnjone.com	China	874	58
BINBO BIOLOGICAL CO.,LTD	+8618629063126	info@binbobiological.com	China	282	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	885	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shaanxi Yikanglong Biotechnology Co., Ltd.	17791478691	yklbiotech@163.com	CHINA	296	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58

Supplier	Advantage
Chongqing Zhihe Biopharmaceutical Co., Ltd.	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
BINBO BIOLOGICAL CO.,LTD	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Nanjing Finetech Chemical Co., Ltd.	55
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Shaanxi Yikanglong Biotechnology Co., Ltd.	58
Chengdu Biopurify Phytochemicals Ltd.	58

View Lastest Price from Naringenin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-24	Naringenin 480-41-1	US $0.00-0.00 / kg	0.10000000149011612kg	99%	2000kg	Chongqing Zhihe Biopharmaceutical Co., Ltd.
2024-04-24	Naringenin 480-41-1	US $0.00-0.00 / kg	0.10000000149011612kg	≥98%	20tons	Chongqing Zhihe Biopharmaceutical Co., Ltd.
2024-04-22	Naringenin 480-41-1	US $0.00 / kg	1kg	98%	1000 kg	BINBO BIOLOGICAL CO.,LTD

Naringenin
480-41-1
US $0.00-0.00 / kg
99%
Chongqing Zhihe Biopharmaceutical Co., Ltd.

Naringenin
480-41-1
US $0.00-0.00 / kg
≥98%
Chongqing Zhihe Biopharmaceutical Co., Ltd.

Naringenin
480-41-1
US $0.00 / kg
98%
BINBO BIOLOGICAL CO.,LTD

Naringenin Spectrum

Naringenin(480-41-1)¹HNMR

480-41-1(Naringenin)Related Search:

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Naringin D4 NARINGENIN CHALCONE,NARINGENIN CHALCONE ISOFLAVONES 6,8-DIMETHYL-4',5,7-TRIHYDROXYFLAVANONE 5,7-DIHYDROXY-3',4',5'-TRIMETHOXYFLAVANONE

NARINGENIN-7-RUTINOSIDE,NARINGENIN-7-O-RUTINOSIDE,NARINGENIN-7-RUTINOSIDE,NARINGENIN-7-O-RUTINOSIDE ERIOCITRIN ERIODICTYOL

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naringetol 4’,5,7-trihydroxy-flavanon S-Dihydrogenistein NSC 34875 NSC 11855 (S)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-ben 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-, (S)- 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-chromanone 5',7-trihydroxyflavanone flavanone naringenin Flavanone, 4',5,7-trihydroxy- NARINGENIN-CMPD pelargidanon (2S)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H- 1-benzopyran-4-one,99%e.e. NARINGENIN hplc NARINGENIN (4'',5,7-TRIHYDROXYFLAVANONE) NARINGENIN WITH HPLC salipurol salipurpol 5,7,4'-TRIHYDROXYFLAVANONE (+/-)-4',5,7-TRIHYDROXYFLAVANONE 4',5,7-TRIHYDROXYFLAVANONE (+/-)-2,3-DIHYDRO-5,7-DIHYDROXY-2-(4-HYDROXYPHENYL)-4H-1-BENZOPYRAN-4-ONE TIMTEC-BB SBB006461 (+/-)-NARINGENIN NARINGENIN 4',5,7-Trihydroxyflavanone, Naringetol, Salipurpol, (S)-2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone (2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one Naringenin，Naringen，4',5,7-Trihydroxyflavanone 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-, (2S)- (2S)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one (2S)-2α-(4-Hydroxyphenyl)-5,7-dihydroxy-2,3-dihydro-4H-1-benzopyran-4-one 4',5,7-TrihydroxyflavanoneNaringenin 3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-(s)-4h-1-benzopyran-4-on Derivative of (2R)-5,7-Dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one 4'',5,7-Trihydroxyflavanone,naringetol (S)-5,7-Dihydroxy-2-(4-hydroxyphenyl)chroMan-4-one (2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one Nano Liposomal naringetol 7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one Nano Liposomal Naringenin (s)-Naringenin 480-41-1 Naringenin USP/EP/BP Naringenin /naringetol naringenine 5,7-Dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one 5,7-DIHYDROXY-2-(4-HYDROXYPHENYL)CHROMAN-4-ONE NARIGENIN (2S)-Naringenin (s)-naringenin ringenin Natural Citrus extract Naringenin Naringenin (6CI) 4',5,7- Trihydroxy Flavanone (or ) Naringenin 480-41-1 480-41-4