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Closantel

Closantel structure

CAS No.: 57808-65-8

Chemical Name:: Closantel

Synonyms: Zycloz;Diantel;R-31520;Closante;CLOSANTEL;faskoverm;5-diiodo-y-;iodobenzamide;CLOSANTEL BASE;Cyanoliodamide

CBNumber:: CB5360606

Molecular Formula:: C22H14Cl2I2N2O2

Molecular Weight:: 663.07

MDL Number:: MFCD00661151

MOL File:: 57808-65-8.mol

Last updated:2024-04-23 19:22:53

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Closantel Properties

Melting point	217.8°
Boiling point	590.5±50.0 °C(Predicted)
Density	1.8759 (estimate)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml
pka	5.99±0.48(Predicted)
CAS DataBase Reference	57808-65-8(CAS DataBase Reference)
FDA UNII	EUL532EI54

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301-H413

Precautionary statements

P273-P301+P310+P330

Hazard Codes

Risk Statements

RIDADR

2811

WGK Germany

RTECS

CV2444250

HazardClass

6.1(b)

PackingGroup

III

Toxicity

A veterinary drug for the treatment of fluke and nematode infestations. In 1993, some was included in a batch of donated drugs sent to Lithuania. Attempts to match the product with the names of other medicines on accompanying literature resulted in its misidentification as a treatment for endometriosis. Eleven women lost their eyesight; though this has since returned, they were left with eye pain and are unable to work.

NFPA 704

	0
2		0

Closantel price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	34093	Closantel PESTANAL	57808-65-8	100mg	$117	2024-03-01	Buy
Cayman Chemical	20531	Closantel ≥98%	57808-65-8	50mg	$57	2024-03-01	Buy
Cayman Chemical	20531	Closantel ≥98%	57808-65-8	100mg	$89	2024-03-01	Buy
Cayman Chemical	20531	Closantel ≥98%	57808-65-8	500mg	$330	2024-03-01	Buy
Cayman Chemical	20531	Closantel ≥98%	57808-65-8	1g	$547	2024-03-01	Buy

Product number	Packaging	Price	Buy
34093	100mg	$117	Buy
20531	50mg	$57	Buy
20531	100mg	$89	Buy
20531	500mg	$330	Buy
20531	1g	$547	Buy

Closantel Chemical Properties,Uses,Production

Description

Closantel is a kind of synthetic anti parasitic agent which is actively against liver fluke, bloodsucking nematodes and larval stages of some arthropods in sheep and cattle. Its mechanism of action is through decoupling the mitochondrial oxidative phosphorylation, thus inhibiting the production of ATP. Therefore, it inhibit their energy generation of the parasite, causing their death. It is mainly used for the treatment and prevention of several infections caused by many kinds of parasites such as Fasciola hepatica, Fasciola gigantica, Haemonchus concortus, Haemonchus placei, Bunostomum phlebotomum, Oesophagostomum radiatum and Strongyloides papillosus in cattle and sheep.

References

http://www.interchemie.com/veterinary-medicines/closan-50.html

Chemical Properties

White to light yellow powder

Uses

antianginal, antihypertensive

Definition

ChEBI: N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide is an aromatic amide resulting from the formal condensation of the carboxy group of 3,5-diiodosalicylic acid with the amino group of aniline substituted at positions 2, 4, and 5 by methyl, (4-chlorophenyl)(cyano)methyl, and methyl groups respectively. It is a nitrile, a member of phenols, an organoiodine compound, a monocarboxylic acid amide, an aromatic amide and a member of monochlorobenzenes.

Closantel synthesis

Synthesis of Closantel from 4-Chlorobenzyl cyanide

Closantel Preparation Products And Raw materials

Raw materials

Preparation Products

Closantel Suppliers

Global( 245)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	616	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618740459177	sarah@tnjone.com	China	958	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	+8617702722807	admin@hbouhuang.com	China	2991	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8823	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Nantong Guangyuan Chemicl Co,Ltd	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Hebei Guanlang Biotechnology Co., Ltd.	58
Xiamen AmoyChem Co., Ltd	58

View Lastest Price from Closantel manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-23	Closantel 57808-65-8	US $10.00 / kg	1kg	99.7%	200000kg	Ouhuang Engineering Materials (Hubei) Co., Ltd
2024-04-07	Closantel 57808-65-8	US $0.00 / kg	1kg	99%	1000kg	Shaanxi TNJONE Pharmaceutical Co., Ltd
2024-03-08	Closantel 57808-65-8	US $10.00 / kg	1kg	99%	1000kg	Nantong Guangyuan Chemicl Co,Ltd

Closantel
57808-65-8
US $10.00 / kg
99.7%
Ouhuang Engineering Materials (Hubei) Co., Ltd

Closantel
57808-65-8
US $0.00 / kg
99%
Shaanxi TNJONE Pharmaceutical Co., Ltd

Closantel
57808-65-8
US $10.00 / kg
99%
Nantong Guangyuan Chemicl Co,Ltd

Closantel Spectrum

Closantel(57808-65-8)¹HNMR

57808-65-8(Closantel)Related Search:

CHLOROPHOSPHONAZO III Cyhalothrin Cyhalothrin Niclosamide ethanolamine salt Niclosamide

theta-Cypermethrin BETA-CYPERMETHRIN Oxyclozanide 2-(4-Amino-2-chloro-5-methylphenyl)-2-(4-chlorophenyl)acetonitrile 2-HYDROXY-5-IODO-BENZALDEHYDE

2-(2-Chlorophenyl)acetonitrile 3-Methylbenzyl cyanide 3,5-DIIODOSALICYLALDEHYDE Difluorochloromethane 3-Iodobenzylamine hydrochloride

(4-AMINOPHENYL)PHENYLACETONITRILE HYDROCHLORIDE,97% 2-(4-aminophenyl)propiononitrile closantel sodium salt,CLOSANTEL SODIUM,CLOSANTEL(NA)

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5-diiodo-y- benzamide,n-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydrox faskoverm CLOSANTEL CLOSANTEL BASE N-[5-CHLORO-4-(4-CHLORO-ALPHA-CYANOBENZYL)-2-METHYLPHENYL]-2-HYDROXY-3,5-DIIODOBENZAMIDE n-[5-chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamid iodobenzamide n-(5-chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-di 5'-CHLORO-4'-(4-CHLORO-ALPHA-CYANOBENZYL)-3,5-DIIODO-2'-METHYLSALICYLANILIDE N-[5-CHLORO-4(4-CHLOROPHENYL)CYANOMETHYL]-2-METHYLPHENYL]-2-HYDROXYL-3,5-DIIODO BENZAMIDE Benzamide, N-5-chloro-4-(4-chlorophenyl)cyanomethyl-2-methylphenyl-2-hydroxy-3,5-diiodo- 5'-chloro-4'-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2'-methylsalicylanilide CLOSANTEL(PATENT) N-[5-CHLORO-4(4-CHLOROPHENYL)CYANOMETHYL]-2-METHYLPHENYL]-2-HYDROXYL-3,5-DIIODOBENZAMIDE(CLOSANTEL) N-[5-Chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide N-[5-Chloro-4-(4-chloro-α-cyanobenzyl)-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide, 5μ-Chloro-4μ-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2μ-methylsalicylanilide Diantel N-(5-Chloro-4-((4-chlorophenyl)cyanomethyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide R-31520 Zycloz 5'-Chloro-.alpha.4-(p-chlorophenyl)-.alpha.4-cyano-3,5-diiodo-2',4'-salicyloxylidide Benzamide, N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hy Closantelfreebase N-(5-Chloro-4-[(RS)-(4-chlorophenyl)cyanomethyl]-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide Closante Closantel Solution in Methanol/DMSO, 1000ug/mL Cyanoliodamide Closantel N-[5-chloor-4-[(4-chloorfenyl)-cyanomethyl]-2-methylfenyl]-2- hydroxy-3,5-di-joodbenzamide 57808-65-8 57805-65-8 C22H14Cl2I2N2O2 COREG CR