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Ascomycin

Ascomycin structure

CAS No.: 11011-38-4

Chemical Name:: Ascomycin

Synonyms: AAG;FK-520;CGTHBA;CS-740;Ascomycin;FR-900520;Nsc106410;Aids093221;IMMUNOMYCIN;Aids-093221

CBNumber:: CB5406331

Molecular Formula:: C43H69NO12

Molecular Weight:: 792.01

MDL Number:: MFCD06198665

MOL File:: 11011-38-4.mol

Last updated:2024-04-23 16:18:34

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Ascomycin Properties

Melting point	158 - 161°C
storage temp.	-20°C
solubility	Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml with warming).
form	White crystalline solid
color	White
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
EWG's Food Scores	1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08,GHS07
Signal word	Warning
Hazard statements	H351-H413-H361-H302
Precautionary statements	P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501-P201-P202-P281-P308+P313-P405-P501
RTECS	CI7570000

Ascomycin price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SAB2501813	Anti-Nprl3 antibody produced in goat affinity isolated antibody, buffered aqueous solution	11011-38-4	100μG	$568	2024-03-01	Buy
Sigma-Aldrich	182800	Ascomycin, Streptomyces hygroscopicus - CAS 11011-38-4 - Calbiochem An ethyl analog of FK506 with similar immunosuppressant properties.	11011-38-4	1mg	$205	2022-05-15	Buy
Usbiological	207066	Ascomycin	11011-38-4	1mg	$273	2021-12-16	Buy
Usbiological	A3698-75	Ascomycin	11011-38-4	25mg	$196	2021-12-16	Buy
Biorbyt Ltd	orb545956	Ascomycin >98%	11011-38-4	25mg	$280.5	2021-12-16	Buy

Product number	Packaging	Price	Buy
SAB2501813	100μG	$568	Buy
182800	1mg	$205	Buy
207066	1mg	$273	Buy
A3698-75	25mg	$196	Buy
orb545956	25mg	$280.5	Buy

Ascomycin Chemical Properties,Uses,Production

Description

Ascomycin (11011-38-4) is an analog of FK-506 (Cat.# 10-1103). Potent immunosuppressant1. Binds to FKBP122 and inhibits calcineurin and NFAT. Ascomycin displays anti-inflammatory effects in skin diseases3. Cell permeable and active in vivo.

Uses

A potent immunosuppressive agent and could be used as a potential therapeutic agent for autoimmune diseases.

General Description

An ethyl analog of FK506 with similar immunosuppressant properties. Acts by binding to immunophilins. Inhibits the synthesis of Th-1 and Th-2 type cytokines in target cells.

Biochem/physiol Actions

Product does not compete with ATP.

Enzyme inhibitor

This antifungal antibiotic (FW = 792.02 g/mol; CAS 104987-12-4; Solubility: 50 mM in DMSO), also known as FK520, isolated from Streptomyces hygroscopicus, is also a powerful immunosuppressant. Note that ascomycin is a structural analogue of tacrolimus (or FK506) and, as such, operates by a similar mechanism of action (See Tacrolimus). Ascomycin inhibits allogenic T-lymphocyte proliferation and calcineurin phosphatase activity.

References

1) Hatanaka et al. (1988), FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physio-chemical and biological characteristics; J. Antibiot. (Tokyo), 41 1592 2) Petros et al. (1991), NMR studies of an FK506 analogue [U-13C]ascomycin, bound to FKBP: conformation and regions of ascomycin involved in binding; J. Med. Chem., 34 2925 3) Mollison et al. (1999), A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases; J. Invest. Dermatol., 112 729

Ascomycin Preparation Products And Raw materials

Raw materials

Preparation Products

Ascomycin Suppliers

Global( 189)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12457	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29322	58
Hangzhou ICH Biofarm Co., Ltd	+undefined8613073685410	sales@ichemie.com	China	985	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shanghai Arbor Chemical Co., Ltd.	021-60451682	act@arborchemical.com	CHINA	906	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Shenzhen Excellent Biotech Co., Ltd.	13480692018	ramyan@ex-biotech.com	CHINA	954	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Dideu Industries Group Limited	58
Hangzhou ICH Biofarm Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shanghai Arbor Chemical Co., Ltd.	58
Xiamen AmoyChem Co., Ltd	58
Chongqing Chemdad Co., Ltd	58
Shenzhen Excellent Biotech Co., Ltd.	58

View Lastest Price from Ascomycin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-23	Ascomycin 11011-38-4	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
2024-03-16	Ascomycin 11011-38-4	US $0.00 / KG	100g	98%+	100kg	WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2023-11-01	Ascomycin 11011-38-4	US $0.00-0.00 / g	100g	99.5%	100kg	Hangzhou ICH Biofarm Co., Ltd

Ascomycin
11011-38-4
US $1.10 / g
99.9%
Dideu Industries Group Limited

Ascomycin
11011-38-4
US $0.00 / KG
98%+
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Ascomycin
11011-38-4
US $0.00-0.00 / g
99.5%
Hangzhou ICH Biofarm Co., Ltd

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ASCOMYCIN, STREPTOMYCES HYGROSCOPICUS ASCOMYCIN, STREPTOMYCES HYGROSCOPICUS VAR ASCOMYCETICUS FR-900520 FK-520 IMMUNOMYCIN AAG ASCOMYCIN (IMMUNOMYCIN, FR-900520) \ INH IBITS CALCINEURIN (PP2B) (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone Ascomycin Ascomycin (FK520) 15,19-Epoxy-3H-pyrido[2,1-C][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26as)- Aids093221 Aids-093221 Nsc106410 Anti-Nprl3 antibody produced in goat CGTHBA nitrogen permease regulator-like 3 (S. cerevisiae) RP23-177M10.6 Ascomycin, >=98.5% Ascomycin, Streptomyces hygroscopicus - CAS 11011-38-4 - Calbiochem CS-740 Ascomycin (Immunomycin Ascomycin (Immunomycin,FK-520) Ascomycin 1 17-Ethyl-1,14-dihydroxy-12-[1-(4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl]-23,25-dimethoxy-13,19,2 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]- 11011-38-4 Antibiotics Antibiotics A to Z Antibiotics A-F BioChemical Immunosuppressant API