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((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2

CAS No.
172997-92-1
Chemical Name:
((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2
Synonyms
BWX 46;((CYS31,NVA34)-NPY (27-36))2;((Cys??,Nva??)-Neuropeptide Y (27-36))?;((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2;(H-TYR-ILE-ASN-LEU-CYS-THR-ARG-NVA-ARG-TYR-NH2)2;(H-Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2)2, (Disulfide bond);((Cys31, Nva 34)-Neuropeptide Y (27-36))2 (H-Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2)2 (Disulfide bond);L-Tyrosinamide, L-tyrosyl-L-isoleucyl-L-asparaginyl-L-leucyl-L-cysteinyl-L-threonyl-L-arginyl-L-norvalyl-L-arginyl-, bimol. (5→5')-disulfide
CBNumber:
CB5412194
Molecular Formula:
C116H186N36O28S2
Molecular Weight:
2597.07
MDL Number:
MFCD00798765
MOL File:
172997-92-1.mol
Last updated:2023-05-18 11:31:02

((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2 Properties

Density 1.46±0.1 g/cm3(Predicted)
storage temp. -15°C
solubility insoluble in H2O; insoluble in EtOH; ≥260.4 mg/mL in DMSO with ultrasonic
form solid
Water Solubility Soluble to 10 mg/ml in water

((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2 price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 254838 BWX 46 172997-92-1 1mg $516 2021-12-16 Buy
Biosynth Carbosynth FC109067 ((Cys31, Nva 34)-Neuropeptide Y (27-36))2 (H-Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2)2 (Disulfide bond) 172997-92-1 1mg $639 2021-12-16 Buy
Biosynth Carbosynth FC109067 ((Cys31, Nva 34)-Neuropeptide Y (27-36))2 (H-Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2)2 (Disulfide bond) 172997-92-1 2mg $1111.3 2021-12-16 Buy
Biosynth Carbosynth FC109067 ((Cys31, Nva 34)-Neuropeptide Y (27-36))2 (H-Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2)2 (Disulfide bond) 172997-92-1 100ug $106 2021-12-16 Buy
Biosynth Carbosynth FC109067 ((Cys31, Nva 34)-Neuropeptide Y (27-36))2 (H-Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2)2 (Disulfide bond) 172997-92-1 250ug $210 2021-12-16 Buy
Product number Packaging Price Buy
254838 1mg $516 Buy
FC109067 1mg $639 Buy
FC109067 2mg $1111.3 Buy
FC109067 100ug $106 Buy
FC109067 250ug $210 Buy

((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2 Chemical Properties,Uses,Production

Biological Activity

the actions of neuropeptide y (npy) are mediated by at least six g-protein coupled receptors denoted as y1, y2, y3, y4, y5, and y6. investigations using receptor selective ligands and receptor knock-out mice show that npy effects on feeding are mediated by both y1 and y5 receptors. bwx 46 is a y5 receptor selective agonist.

in vitro

bwx 46 selectively bound y5 receptors, and inhibited camp synthesis by y5 cells with potencies comparable to that of npy. in addition, bwx 46 (10 μm) exhibited no significant effect on the camp synthesis by y1, y2, and y4 cells. thus, bwx 46 constitutes the lowest molecular weight y5 selective agonist reported to date [1].

in vivo

intrahypothalamic-injection of 30 and 40 μg of bwx 46 stimulated the food intake by rats in a gradual manner, reaching maximal level 8 h after injection. this response was similar to that exhibited by other y5 selective agonists, but differed from that of npy, which exhibited a rapider orexigenic stimulus within 1 h [1].

IC 50

0.5 nm for y5

References

[1] ambikaipakan balasubramaniam, sulaiman sheriff, weixu zhai, william t. chance. bis(31/31’){[cys31, nva34]npy(27–36)-nh2}: a neuropeptide y (npy) y5 receptor selective agonist with a latent stimulatory effect on food intake in rats. peptides 23 (2002) 1485–1490

((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2 Preparation Products And Raw materials

Raw materials

Preparation Products

((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2 Suppliers

Global( 55)Suppliers
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Shanghai Daken Advanced Materials Co.,Ltd
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3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69

View Lastest Price from ((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2 pictures 2020-02-14 ((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2
172997-92-1
US $7.00 / KG 1KG 99% 100KG Career Henan Chemical Co

((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2 Spectrum

172997-92-1(((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2)Related Search:

((CYS31,NVA34)-NEUROPEPTIDE Y (27-36))2 ((CYS31,NVA34)-NPY (27-36))2 BWX 46 (H-TYR-ILE-ASN-LEU-CYS-THR-ARG-NVA-ARG-TYR-NH2)2 (H-Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2)2, (Disulfide bond) ((Cys31, Nva 34)-Neuropeptide Y (27-36))2 (H-Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2)2 (Disulfide bond) L-Tyrosinamide, L-tyrosyl-L-isoleucyl-L-asparaginyl-L-leucyl-L-cysteinyl-L-threonyl-L-arginyl-L-norvalyl-L-arginyl-, bimol. (5→5')-disulfide ((Cys??,Nva??)-Neuropeptide Y (27-36))? 172997-92-1 C116H186N36O28S2