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CAS No. 67-66-3
Chemical Name: Chloroform
Synonyms: r20;TCM;R 20;HCC20;CHCl3;freon20;Freon 20;NCI-C02686;Trichlorom;CHLOROFORM
CBNumber: CB5413313
Molecular Formula: CHCl3
Formula Weight: 119.38
MOL File: 67-66-3.mol
Chloroform Property
Melting point : -63 °C
Boiling point : 61 °C
density : 1.492 g/mL at 25 °C(lit.)
vapor density : 4.1 (vs air)
vapor pressure : 160 mm Hg ( 20 °C)
refractive index : n20/D 1.445(lit.)
Fp : 60.5-61.5°C
storage temp. : 2-8°C
solubility : Miscible with diethyl ether, oils, ligroin, alcohol, carbon tetrachloride and carbon disulfide.
pka: 15,5(at 25℃)
form : Liquid
color : ≤10(APHA)
Relative polarity: 0.259
Water Solubility : 8 g/L (20 ºC)
Merck : 14,2141
BRN : 1731042
CAS DataBase Reference: 67-66-3(CAS DataBase Reference)
NIST Chemistry Reference: Chloroform(67-66-3)
EPA Substance Registry System: Methane, trichloro-(67-66-3)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : Xn,F,T,Xi
Risk Statements : 45-46-11-23/24/25-36/37/38-48/20/22-40-38-22-67-66-36/38-41-37/38-39/23/24/25-20-63-20/22-36-48/20
Safety Statements : 9-16-26-36-36/37-45-36/37/39-25-23-53-33-7
RIDADR : UN 1888 6.1/PG 3
WGK Germany : 3
RTECS : FS9100000
TSCA : Yes
HazardClass : 6.1
PackingGroup : III
Hazardous Substances Data: 67-66-3(Hazardous Substances Data)
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger P260, P264, P270, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Chloroform Chemical Properties,Usage,Production

Chemical Properties
Colorless liquid
Suitable for HPLC, spectrophotometry, environmental testing
Meets ACS specifications.
Facilitates recovery of the aqueous phase of PCRs which have been overlaid with mineral oil.
ChEBI: A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines.
General Description
A clear colorless liquid with a characteristic odor. Denser (12.3 lb / gal) than water and slightly soluble in water. Hence sinks in water. Nonflammable under most conditions, but burns under extreme conditions. May cause illness by inhalation, skin absorption or ingestion. Used as a solvent, to make other chemicals, as a fumigant.
Air & Water Reactions
Slightly soluble in water. Dissolves in water to form a corrosive solution of hypochlorous acid which decomposes on standing to chlorine, oxygen, and chloric acid.
Reactivity Profile
A mixture of acetone and Chloroform in a residue bottle exploded. Since addition of acetone to Chloroform in the presence of base will result in a highly exothermic reaction, Chloroform is thought that a base was in the bottle. [MCA Case History 1661(1970)]. Powdered aluminum and carbon tetrachloride(also methyl chloride and Chloroform or mixtures of these chemicals) exploded when heated(to 153°C.) and by impact, [Chem. Eng. News 32:258(1954); UL Bull. Research 34(1945), ASESB Pot. Incid. 39(1968)]. An inadequately cooled addition of sodium to a Chloroform-methanol mixture (sodium methoxide) caused a violent explosion, [MCA Case History No. 693]. Chloroform is incompatible with dinitrogen tetraoxide, fluorine, sodium metal and alcohols, nitromethane, and triisopropylphosphine.
Health Hazard
Chloroform is classified as moderately toxic. Probable oral lethal dose for humans is 0.5 to 5 g/kg (between 1 ounce and 1 pint) for a 150 lb. person. The mean lethal dose is probably near 1 fluid ounce (44 g). It is a human suspected carcinogen. Also, it is a central nervous system depressant and a gastrointestinal irritant. It has caused rapid death attributable to cardiac arrest and delayed death from liver and kidney damage.
Fire Hazard
Container may explode in the heat of fire. When heated Chloroform liberates phosgene, hydrogen chloride, chlorine and toxic and corrosive oxides of carbon and chlorine. Chloroform explodes when in contact with aluminum powder or magnesium powder or with alkali metals (e.g., lithium, sodium, and potassium) and dinitrogen tetroxide. Chloroform reacts vigorously with acetone in the presence of potassium hydroxide or calcium hydroxide. Chloroform is oxidized by strong oxidizers such as chromic acid forming phosgene and chlorine. Chloroform reacts vigorously with triisopropylphosphine. Chloroform develops acidity from prolonged exposure to air and light.
Chloroform Preparation Products And Raw materials
Raw materials
Chloral 2,2,2-TRICHLORO-1-ETHOXYETHANOL Calcium oxide Chlorine Hydrochloric acid Methanol Sodium hydroxide Calcium hypochlorite Calcium hydroxide
Preparation Products
BETA-BUTYROLACTONE 4-BIPHENYLSULFONYL CHLORIDE 2,2'-OXYDIACETYL CHLORIDE 2-Chloro-5-chloromethylthiazole N-Methyl-4-pyridinamine 2-ETHOXYPHENYL ISOTHIOCYANATE 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OL 2-Diazo-1-naphthol-5-sulfonyl chloride Ethyl 3-(N,N-dimethylamino)acrylate 3-CHLORO-2-METHYLPHENYL ISOTHIOCYANATE 3-Fluoro-4-hydroxybenzaldehyde 3-Ethoxyphenol biocide agent C-38 Acipimox 4-(METHYLSULFINYL)PHENOL 3,5-DIMETHYLPHENYL ISOTHIOCYANATE 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole N-Heptafluorobutyrylimidazole 2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL ISOTHIOCYANATE 2-Bromo-2',4'-dichloroacetophenone SULFUR TRIOXIDE TRIMETHYLAMINE COMPLEX 4-SULFAMIDOBENZOYL CHLORIDE DMF COMPLEX PYRIPROPANOL N-ethoxycarbonyl N,N′,N′-trimethyl guanidine N-FORMYLGLYCINE ETHYL ESTER orange yellow (1R,3S)-1,2,2-trimethyl-1,3-cycloperltanediamine poly (3-alkyl thiophene) fiber 1-ETHYL-3-METHYLIMIDAZOLIUM BIS(TRIFLUOROMETHYLSULFONYL)IMIDE, 99% [EMIIM] 2-Amino-5-bromothiazole monohydrobromide DIBENZYL SULFOXIDE TERT-BUTYL ISOCYANIDE PYRROLIDONE HYDROTRIBROMIDE 2,4-Dichlorobenzenesulfonyl chloride 3,5-DIMETHOXYPHENYL ISOTHIOCYANATE DIMETHYL 2,6-PYRIDINEDICARBOXYLATE 4-N-BUTYLTOLUENE 5-BROMO-2-(MORPHOLIN-4-YL)PYRIMIDINE 4-CHLORO-2-METHYLPHENYL ISOTHIOCYANATE 2-CHLORO-4-METHYLPHENYL ISOTHIOCYANATE
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67-66-3(Chloroform)Related Search:
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Solvents for Spectrophotometry Standard Solution of Volatile Organic Compounds for Water & Soil Analysis HPLC Solvents Solvents for HPLC & Spectrophotometry Standard Solutions (VOC) formyltrichloride Freon 20 freon20 HCC20 Methane trichloride Methane, trichloro- Methane,trichloro- methanetrichloride Methenyl trichloride methenylchloride methenyltrichloride NCI-C02686 R 20 R 20 (refrigerant) r20 r20(refrigerant) Rcra waste number U044 rcrawastenumberu044 TCM Trichloormethaan Trichlormethan trichlormethan(czech) Trichloroform trichloro-methan Triclorometano Methenyl trichoride Trichloromethare Refrigerant R20 TRICHLOROMETHANE SPECTRANAL, REAG. ACS, STABILIZED WITH APPROX. 1 % ETHANOL CHLOROFORM, ANHYDROUS, 99+% CHLOROFORM, >=99.9%, PRA GRADE CHLOROFORM 'B&J BRAND', STAB. 1 L CHLOROFORM, ACS REAGENT, >=99.8% CHLOROFORM PCR REAGENT NMR STD/2% CHLOROFORM/CHLOROFORM-D(99.8% NMR STD/5% CHLOROFORM/ACETONE-D6/3MMX8" CHLOROFORM, REAGENTPLUS >=99.8%, CONTAINS 0.5-1.0% ETHANOL AS STABILIZER TRICHLOROMETHANE R. G., REAG. ISO, REAG. PH. EUR., STAB. WITH APPROX. 1 % ETHANOL TRICHLOROMETHANE CHROMASOLV, FOR HIGH-PE RFORMANCE LIQUID CHROMATOGRA-PHY, STABIL CHLOROFORM MOLECULAR BIOLOGY REAGENT CHLOROFORM, 99.9%, HPLC GRADE (FOR EUROPE ONLY) CHLOROFORM, FOR IR-SPECTROSCOPY, STAB. W . ~0.5% ETOH CHLOROFORM >=99.9% CAPILLARY GC GRADE& CHLOROFORM >=99.8% A.C.S. REAGENT (SA& CHLOROFORM, >=99.8%, A.C.S. SPECTROPHOTOMETRIC GRADE CHLOROFORM, ACS, STAB. WITH ~1% ETHANOL CHLOROFORM REAGENT GRADE CHLOROFORM >=99.8% A.C.S. SPECTROPHOT& NMR STD/20% CHLOROFORM/ACETONE-D6/5MMX8" CHLOROFORM DIST. STAB. WITH 1% ETHANOL CHLOROFORM CHROMASOLV FOR HPLC >=99& CHLOROFORM 99.9% B&J BRAND STABILIZE& TRICHLOROMETHANE PURISS., PH-QUALITY,STABILIZED WITH APPROX. 1 % ETHANOL
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