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VISNAGIN

CAS No.
82-57-5
Chemical Name:
VISNAGIN
Synonyms
VISNAGIN;visnagine;visnagidin;VISNAGIN(P);VISNAGIN(RG);Metofuroxime;desmethoxykhellin;VISNAGIN USP/EP/BP;LABOTEST-BB LT00441024;4-Methoxy-7-methyl-5H-furo
CBNumber:
CB5434295
Molecular Formula:
C13H10O4
Molecular Weight:
230.22
MDL Number:
MFCD00005008
MOL File:
82-57-5.mol
Last updated:2023-05-25 18:01:13

VISNAGIN Properties

Melting point 139-142 °C
Boiling point 292.2°C (rough estimate)
Density 1.1302 (rough estimate)
refractive index 1.4300 (estimate)
storage temp. 2-8°C
solubility Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
form Fine Crystalline Powder
color Beige
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
LogP 2.260 (est)
CAS DataBase Reference 82-57-5(CAS DataBase Reference)
FDA UNII P64438MLBW

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22
RTECS  LV1420000
HS Code  29162000

VISNAGIN price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T341649 VISNAGIN Aldrich 82-57-5 1g $179 2024-03-01 Buy
TRC V675008 Visnagin 82-57-5 500mg $65 2021-12-16 Buy
Biosynth Carbosynth FV42573 Visnagin 82-57-5 5G $100 2021-12-16 Buy
Biorbyt Ltd orb546235 Visnagin >98% 82-57-5 25mg $127.5 2021-12-16 Buy
Biosynth Carbosynth FV42573 Visnagin 82-57-5 10g $175 2021-12-16 Buy
Product number Packaging Price Buy
T341649 1g $179 Buy
V675008 500mg $65 Buy
FV42573 5G $100 Buy
orb546235 25mg $127.5 Buy
FV42573 10g $175 Buy

VISNAGIN Chemical Properties,Uses,Production

Description

Visnagin (82-57-5) is a natural product isolated from the plant Ammi visnaga.? It displays protective effects against doxorubicin-induced cardiomyopathy via inhibition of mitochondrial malate dehydrogenase resulting in a decrease in cardiomyocyte apoptosis.1

Chemical Properties

BEIGE FINE CRYSTALLINE POWDER

Uses

antiinflammatory, neuroprotective

Definition

ChEBI: Visnagin is a furanochromone that is furo[3,2-g]chromen-5-one which is substituted at positions 4 and 7 by methoxy and methyl groups, respectively. Found in the toothpick-plant, Ammi visnaga. It has a role as a phytotoxin, an EC 1.1.1.37 (malate dehydrogenase) inhibitor, a vasodilator agent, an antihypertensive agent, an anti-inflammatory agent and a plant metabolite. It is a furanochromone, an aromatic ether and a polyketide. It is functionally related to a 5H-furo[3,2-g]chromen-5-one.

Purification Methods

Crystallise visnagin from water. It is soluble in CHCl3 but slightly soluble in EtOH. [Aneja et al. Tetrahedron 3 230 1958, Beilstein 19 III/IV 2640.]

References

1) Liu et al. (2014), Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase; Sci. Transl. Med. 6 266ra170

VISNAGIN Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 90)Suppliers
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5-METHOXY-2-METHYL-FURANOCHROMONE 4-METHOXY-7-METHYL-5H-FURO[3,2-G][1]-BENZOPYRAN-5-ONE 4-METHOXY-7-METHYL-FURO[3,2-G]CHROMEN-5-ONE LABOTEST-BB LT00441024 VISNAGIN 2-g)(1)benzopyran-5-one,4-methoxy-7-methyl-5h-furo( desmethoxykhellin visnagidin visnagine VISNAGIN(RG) 4-METHOXY-7-METHYL-5H-FURO[3,2-G][1]-BENZOPYRAN-5-ONE 97% 4-METHOXY-7-METHYL-5H-FURO3,2-Ga1a-BENZOPYRAN-5-ONE, 97% 4-Methoxy-7-methyl-5H-furo[3,2-g][1]benzopyran-5-one,97% 4-Methoxy-7-methyl-5H-furo[3,2-g][1]benzopyran-5-oneVisnagin VISNAGIN(P) 4-Methoxy-7-methyl-5H-furo Metofuroxime 5H-Furo[3,2-g][1]benzopyran-5-one, 4-methoxy-7-methyl- VISNAGIN USP/EP/BP 82-57-5 Heterocyclic Building Blocks Coumarins Building Blocks Chromones