Travoprost | 157283-68-6

Travoprost Properties

alpha	D20 +14.6° (c = 1.0 in methylene chloride)
Boiling point	584.8±50.0 °C(Predicted)
Density	1.245±0.06 g/cm3(Predicted)
Flash point	17 °C
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Dichloromethane (Sparingly, Sonicated), Chloroform (Sparingy), Methanol (Sparing
form	ethanol solution
pka	13.43±0.20(Predicted)
color	Colourless to Light Beige
BCS Class	2
Stability	Light Sensitive
InChIKey	MKPLKVHSHYCHOC-AHTXBMBWSA-N
CAS DataBase Reference	157283-68-6(CAS DataBase Reference)
FDA UNII	WJ68R08KX9
ATC code	S01EE04

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Danger

Hazard statements

H225-H319

Precautionary statements

P210-P233-P240-P241-P242-P305+P351+P338

Hazard Codes

F,Xi

Risk Statements

11-36/37/38

Safety Statements

16-26-36-7

RIDADR

UN 1170 3/PG 2

WGK Germany

1

HS Code

2937500000

NFPA 704

	0
2		0

Travoprost price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR1622	Travoprost Pharmaceutical Secondary Standard; Certified Reference Material	157283-68-6	3mL	$173	2024-03-01	Buy
Sigma-Aldrich	1673001	Travoprost	157283-68-6	3ml	$436	2024-03-01	Buy
Cayman Chemical	16769	Fluprostenol isopropyl ester ≥98%	157283-68-6	1mg	$70	2024-03-01	Buy
Cayman Chemical	16769	Fluprostenol isopropyl ester ≥98%	157283-68-6	5mg	$308	2024-03-01	Buy
Cayman Chemical	16769	Fluprostenol isopropyl ester ≥98%	157283-68-6	10mg	$545	2024-03-01	Buy

Product number	Packaging	Price	Buy
PHR1622	3mL	$173	Buy
1673001	3ml	$436	Buy
16769	1mg	$70	Buy
16769	5mg	$308	Buy
16769	10mg	$545	Buy

Travoprost Chemical Properties,Uses,Production

Description

Travoprost was launched in the US as Travatan?, an ophthalmic solution (0.004%) administered topically for the treatment of elevated intraocular hypertension (lOP) through open-angle glaucoma, a common optic neuropathy and a leading cause of blindness. Travoprost is the isopropyl ester of (+)-fluprostenol, a new prostaglandin derivative belonging to the PGF_2α, analog class. This compound can be prepared in 8 steps from a bicyclic lactone aldehyde by a Wittig alkylidenation followed, after 2 ketonic reductions, by a lactol opening to prostenoic acid while protecting and deprotecting appropriately. Travoprost is a full agonist of FP receptors with a greater affinity than PGF_2α, (K₁ = 52 nM). Pharmacologic studies in rabbits treated daily for a week demonstrated a significant increase of the microvascular optic nerve head blood flow without significant alterations in the systemic flow. In several placebo-controlled clinical studies with hundreds of patients suffering from open-angle glaucoma or ocular hypertension, travoprost (1 to 4 pm daily) dose-dependently reduced lOP (by about 30% at 4 pm); it was shown equal or superior to latanoprost, another prostaglandin analog (5 pm daily) or the adrenergic ~-blocker timolol (500 pm bid). In addition, travoprost was safe and well tolerated with a low incidence of conjunctival hyperaemia.

Chemical Properties

Colorless Oil

Originator

Alcon (US)

Uses

Travoprost is a selective FP prostaglandin receptor agonist used to treat glaucoma (1,2).

Uses

treatment conditions arising from excess uric acid, eg chronic gout

Uses

Selective FP prostaglandin receptor agonist. Isopropyl ester of (+)-fluprostenol. Antiglaucoma

Definition

ChEBI: The isopropyl ester of prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophth lmic solutions of travoprost are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. It is a pro-drug; the isopropyl ester group is hydrolysed by esterases in the co nea to the biologically active free acid, fluprostenol.

brand name

Travatan

General Description

Travoprost (Travatan and Travatan-Z) is supplied asa 2.5- or 5.0-mL sterile 0.004% ophthalmic solution in a4.0- or 7.5-mL size container. Travoprost is claimed to bethe most potent and FP-specific analog in this product category. Cautions and side effects are similar to those givenpreviously.

Travoprost Preparation Products And Raw materials

Raw materials

Preparation Products

Travoprost Suppliers

Global( 401)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Quanjinci New Material Co.,Ltd.	+8615271838296	kyra@quanjinci.com	China	1532	58
Shanghai Affida new material science and technology center	+undefined15081010295	2691956269@qq.com	China	359	58
airuikechemical co., ltd.	+undefined86-15315557071	sales02@airuikechemical.com	China	994	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9352	55
Shanghai finete Pharmaceutical Co., Ltd.	+86-18221039705		CHINA	139	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Zhejiang ZETian Fine Chemicals Co. LTD	18957127338	stella@zetchem.com	China	2141	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58

Supplier	Advantage
Wuhan Quanjinci New Material Co.,Ltd.	58
Shanghai Affida new material science and technology center	58
airuikechemical co., ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Shanghai finete Pharmaceutical Co., Ltd.	55
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Xiamen AmoyChem Co., Ltd	58
Hubei xin bonus chemical co. LTD	58

View Lastest Price from Travoprost manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-17	Travoprost 157283-68-6	US $1.10 / g	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
2024-04-11	Travaprost 157283-68-6	US $0.00-0.00 / g	1g	99.9%	20tons	airuikechemical co., ltd.
2024-04-10	Travoprost 157283-68-6	US $0.00 / Kg/Bag	2Kg/Bag	USP32	20 tons	Sinoway Industrial co., ltd.

Travoprost
157283-68-6
US $1.10 / g
99.0% min
Shaanxi Dideu Medichem Co. Ltd

Travaprost
157283-68-6
US $0.00-0.00 / g
99.9%
airuikechemical co., ltd.

Travoprost
157283-68-6
US $0.00 / Kg/Bag
USP32
Sinoway Industrial co., ltd.

Travoprost Spectrum

Travoprost(157283-68-6)¹HNMR

157283-68-6(Travoprost)Related Search:

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4-Hydroxybenzaldehyde Prostaglandin E1 Bimatoprost Latanoprost (+)-Fluprostenol

9-KETO FLUPROSTENOL 9-keto Fluprostenol isopropyl ester 15-Keto Travoprost

1of4

(+)-9ALPHA,11ALPHA,15R-TRIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, ISOPROPYL ESTER (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic acid 1-methyethyl ester (+/-)-16-(M-TRIFLUOROMETHYLPHENOXY)TETRANORPROSTAGLANDIN F2 15(S)-FLU-IPR 15(S)-FLUPROSTENOL ISOPROPYL ESTER 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-, 1-methylethyl ester, (5Z)- 9ALPHA,11ALPHA,15S-TRIHYDROXY-16(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, ISOPROPYL ESTER (+)-FLUPROSTENOL ISOPROPYL ESTER FLUPROSTENOL ISOPROPYL ESTER FLU-IPR propan-2-yl (e)-7-[(1r,2s,3r,5s)-3,5-dihydroxy-2-[(e)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic Acid 1-Methylethyl Ester AL 6221 Travaprost Travatan TRAVOPROST propan-2-yl 7-[(1R,2S,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate Travoprost (For eye drops) cGMP Travoprost propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoroMethyl)phenoxy]but-1-en-1-yl]cyclopentyl]hept-5-enoate (4-isopropyloxcarbonylbutyl)dipenhylphosphine oxide Travoprost, (±)-16-(m-Trifluoromethylphenoxy)tetranorprostaglandin F2 Travoprostintermediates Travoprost (AL-6221) (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]buten-1-yl][cyclopentyl]hept-5-enoate Travoprost, >=99% trevostaglandin Travoprost Eye Drops Travoprost（Fluprostenol Isopropyl Ester） propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate Trivo Trivoprost Travoprost Impurity 33 Travoprost USP/EP/BP isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate Travoprostum (Z)-Isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate Travoprost D7 TravoprostQ: What is Travoprost Q: What is the CAS Number of Travoprost Q: What is the storage condition of Travoprost Q: What are the applications of Travoprost Travoprost (COLD SHIPMENT REQUIRED) (1673001) Trovoprost ravopros Travoprostt Travoprost API Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(R,E)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoate 157283-68-6 157283-62-7 C26H35F3O6 Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals Prostaglandins