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3-IODO-L-TYROSINE

3-IODO-L-TYROSINE structure

CAS No.: 70-78-0

Chemical Name:: 3-IODO-L-TYROSINE

Synonyms: H-Tyr;NSC210787;3-I-L-Tyr-OH;H-3-I-TYR-OH;Iodotyrosine;H-TYR(M-I)-OH;H-TYR(3-I)-OH;3-Iodo-Tyr-OH;3-IODO-TYROSINE;H-L-TYR(3-I)-OH

CBNumber:: CB5721061

Molecular Formula:: C9H10INO3

Molecular Weight:: 307.09

MDL Number:: MFCD00002608

MOL File:: 70-78-0.mol

MSDS File:: SDS

Last updated:2023-05-10 18:56:37

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3-IODO-L-TYROSINE Properties

Melting point	210 °C (dec.)(lit.)
Density	1.7280 (estimate)
storage temp.	-20°C
solubility	dilute aqueous acid: soluble
form	Solid
Boiling point	391.0±42.0 °C(Predicted)
pka	2.21±0.20(Predicted)
color	White to off-white
Sensitive	Light Sensitive
Merck	14,5047
BRN	2941266
Stability	Hygroscopic
InChIKey	UQTZMGFTRHFAAM-ZETCQYMHSA-N
CAS DataBase Reference	70-78-0(CAS DataBase Reference)
FDA UNII	FRQ98U4U27
EPA Substance Registry System	L-Tyrosine, 3-iodo- (70-78-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P280-P305+P351+P338-P310

Safety Statements

24/25

WGK Germany

8-10-23

HS Code

29225090

NFPA 704

	0
1		0

3-IODO-L-TYROSINE price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	I8250	3-Iodo-L-tyrosine	70-78-0	1g	$68.4	2024-03-01	Buy
Sigma-Aldrich	I8250	3-Iodo-L-tyrosine	70-78-0	5g	$249	2024-03-01	Buy
TCI Chemical	I0075	3-Iodo-L-tyrosine >98.0%(T)	70-78-0	1g	$83	2024-03-01	Buy
TCI Chemical	I0075	3-Iodo-L-tyrosine >98.0%(T)	70-78-0	5g	$329	2024-03-01	Buy
Alfa Aesar	H63789	3-Iodo-L-tyrosine, 98%	70-78-0	1g	$33.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
I8250	1g	$68.4	Buy
I8250	5g	$249	Buy
I0075	1g	$83	Buy
I0075	5g	$329	Buy
H63789	1g	$33.65	Buy

3-IODO-L-TYROSINE Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

3-Iodo-L-tyrosine has been used as an inhibitor for tyrosine hydroxylase enzyme in Drosophila and silkworm pupae.

Uses

A novel flavoprotein responsible for iodide salvage in thyroid glands. A tyrosine hydroxylase inhibitor.

Uses

3-iodo-l-tyrosine is used in the inhibition of tyrosine hydroxylase. 3-iodo-L-tyrosine is used in the rapid induction of prolactin secretion.

Definition

ChEBI: The monoiodotyrosine that is L-tyrosine carrying an iodo-substituent at position C-3 of the benzyl group.

General Description

Iodotyrosine coupled with di-iodotyrosine results in the synthesis of 3,5,3′-tri-iodothyronine (T3) or 3,3′,5′-tri-iodothyronine (rT3).

Biochem/physiol Actions

3-iodotyrosine (3-IY) inhibits tyrosine hydroxylase that catalyzes levodopa (L-DOPA) formation from tyrosine. Iodotyrosine deiodinase enzyme deficiency leads to elevated levels of 3-IY in serum and urine in severe hypothyroidism and goiter.

Purification Methods

Likely impurities are tyrosine, diiodotyrosine and iodide. Crystallise it by dissolving it in concentrated ammonia (~200mg in ~20mL), evaporate to ~5mL and NH4Cl is added to pH4.5—5.0. After a few hours at 0o, the amino acid crystallises in needles. It is filtered off, washed with a little ice-cold H2O and dried in a vacuum. Alternatively dissolve it in dilute ammonia at room temperature, then add dilute acetic acid to pH 6. Store it at 0o. Recrystallisation of ~250mg from H2O (~5mL) removes any diiodotyrosine. It is an inhibitor of tyrosine hydroxylase with a Ki of ~500nM. [Harrington & Rivers Biochem J 38 320 1944, Rivers Chem & Ind (London) 21 1956, Beilstein 14 III 1562, 14 IV 1562.]

3-IODO-L-TYROSINE synthesis

Synthesis of 3-IODO-L-TYROSINE from L-Tyrosine

3-IODO-L-TYROSINE Preparation Products And Raw materials

Raw materials

3,5-Diiodo-L-tyrosine dihydrate L-Tyrosine

Preparation Products

3-IODO-L-TYROSINE Suppliers

Global( 236)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Ryan Pharmachem Technology Co.,Ltd.	+86-512-68780025 +8618962125825	sales@ryanchem.com	China	137	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
GL Biochem (Shanghai) Ltd.	+86-021-61263370 +86-18901917034		CHINA	3904	58
GL Biochem(Binhai) Ltd.	+86-021-61263370 +8615301650015	wuqiuyan@glschina.com	China	2975	58

Supplier	Advantage
Suzhou Ryan Pharmachem Technology Co.,Ltd.	58
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Hubei xin bonus chemical co. LTD	58
Chongqing Chemdad Co., Ltd	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
GL Biochem (Shanghai) Ltd.	58
GL Biochem(Binhai) Ltd.	58

View Lastest Price from 3-IODO-L-TYROSINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-05-12	3-iodo-L -tyrosine 70-78-0	US $0.00-0.00 / kg	5kg	98%	kg grade	Suzhou Ryan Pharmachem Technology Co.,Ltd.
2022-02-19	3-Iodo-l-tyrosine 70-78-0	US $0.00 / KG	1KG	98.5%	100 tons	Honest Joy Holdings Limited
2019-07-10	3-IODO-L-TYROSINE 70-78-0	US $1.00 / ASSAYS	1ASSAYS	98%	1kg,2kg,100kg	Career Henan Chemical Co

3-iodo-L -tyrosine
70-78-0
US $0.00-0.00 / kg
98%
Suzhou Ryan Pharmachem Technology Co.,Ltd.

3-Iodo-l-tyrosine
70-78-0
US $0.00 / KG
98.5%
Honest Joy Holdings Limited

3-IODO-L-TYROSINE
70-78-0
US $1.00 / ASSAYS
98%
Career Henan Chemical Co

3-IODO-L-TYROSINE Spectrum

3-IODO-L-TYROSINE(70-78-0)MS 3-IODO-L-TYROSINE(70-78-0)¹HNMR 3-IODO-L-TYROSINE(70-78-0)IR1 3-IODO-L-TYROSINE(70-78-0)IR2 3-IODO-L-TYROSINE(70-78-0)Raman

70-78-0(3-IODO-L-TYROSINE)Related Search:

REVERSE T3 3,5-Diiodo-L-thyronine 3,3',5-Triiodo-L-thyronine 3,3',5-TRIIODOTHYROPROPIONIC ACID Thyroxine-4-hydroxy-3,5-diiodophenyl Ether DISCONTINUED

3,5-DIIODO-4'-(4-HYDROXYPHENOXY)BENZOIC ACID N-ForMyl Thyroxine 3,5,3',5'-Tetraiodo Thyroaldehyde 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID 4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodobenzeneacetaMide

3,5,3',5'-Tetraiodo Thyrolactic Acid 3,3',5-TRIIODOTHYROACETIC ACID O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine Liothyronine IMpurity E Levothyroxine impurity E

Sodium levothyroxine Levothyroxine sodium N-Acetyl-3,5-diiodo-L-tyrosine

1of4

3-Iodo-4-hydroxyphenylalanine 4-Hydroxy-3-iodophenylalanine (S)-2-AMino-3-(4-hydroxy-3-iodophenyl)propanoic acid L-TYROSINE, 3-IODO- 3-I-L-Tyr-OH 3-Iodo-L-tyrosine≥ 98% (HPLC) H-L-Phe(3-I,4-OH)-OH 3-IODO-TYROSINE 3-IODO-L-TYROSINE 3-MONOIODO-L-TYROSINE S(-)-3-IODO-4-HYDROXY-PHENYLAMINE M-IODO-L-TYROSINE 3-iodine-L- tyrosine H-TYR(M-I)-OH H-TYR(3-I)-OH H-L-TYR(3-I)-OH H-3-IODO-TYR-OH H-3-I-PHE(4-OH)-OH H-3-I-TYR-OH 3-Monoiodo-L-tyrosine 3-Iodo-L-tyrosine Iodotyrosine (2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid 3-IODO-L -TYROSINE 97% 3-Iodo-L-tyrosine,97% 3-Iodo-Tyr-OH 3-Iodo-L-tyrosine,3-Monoiodo-L-tyrosine 3-Iodo-L-tyrosine, 97% 1GR (2S)-2-ammonio-3-(4-hydroxy-3-iodophenyl)propanoate 3-Iodo-L-tyrosine> 3-1odo-L-tyrosine 3-IODO-L-TYROSINE USP/EP/BP Liothyronine Impurity 1 MIT (amino acid) NSC210787 Tyrosine,3-iodo-, L- (8CI) Liothyronine Impurity 2 Metoprolol Impurity 35 H-Tyr 70-78-0 IC6H34OHCH2CHNH2CO2H C9H10INO3 Tyrosine Derivatives Unnatural Amino Acid Derivatives Peptide Synthesis Specialty Synthesis amino Unusual Amino Acids Amino Acids 13C, 2H, 15N Amino Acids Biochemistry Biological-modified Amino Acids Amino Acids & Derivatives Inhibitors Aromatics Chiral Reagents