cis-1,2,3,6-Tetrahydrophthalic anhydride
- CAS No.
- 935-79-5
- Chemical Name:
- cis-1,2,3,6-Tetrahydrophthalic anhydride
- Synonyms
- THPA;CIS-4-CYCLOHEXENE-1,2-DICARBOXYLIC ANHYDRIDE;4-CYCLOHEXENE-1,2-DICARBOXYLIC ANHYDRIDE;CIS-4-CYCLOHEXEN-1,2-DIMETHANOIC ANHYDRIDE;(3aR,7aS)-3a,4,7,7a-tetrahydroisobenzofuran-1,3-dione;CIS-THPA;cis-1,2,3,6-Tetrahyd;cis-1,2,3,6-TetrahydrophthaL;Cis-1,2,3,6-Tetrahydrophthalic;6-Tetrahydrophthalic anhydride
- CBNumber:
- CB5728570
- Molecular Formula:
- C8H8O3
- Molecular Weight:
- 152.15
- MDL Number:
- MFCD00005916
- MOL File:
- 935-79-5.mol
- MSDS File:
- SDS
| Melting point | 98 °C |
|---|---|
| Boiling point | 234.6°C (rough estimate) |
| Density | 1.2143 (rough estimate) |
| vapor density | 5.2 (vs air) |
| vapor pressure | <0.01 mm Hg ( 20 °C) |
| refractive index | 1.4447 (estimate) |
| Flash point | 156 °C |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Toluene,Benzene |
| form | powder to crystal |
| color | White to Almost white |
| Water Solubility | REACTS |
| Sensitive | Moisture Sensitive |
| BRN | 82341 |
| Exposure limits |
ACGIH: TWA 0.01 mg/m3 OSHA: TWA 0.25 ppm(1 mg/m3) NIOSH: IDLH 10 mg/m3; TWA 0.25 ppm(1 mg/m3) |
| CAS DataBase Reference | 935-79-5(CAS DataBase Reference) |
| FDA 21 CFR | 177.2280 |
| EWG's Food Scores | 1-2 |
| FDA UNII | W9Q4666NOS |
| NIST Chemistry Reference | cis-1,2,3,6-Tetrahydrophthalic anhydride(935-79-5) |
| EPA Substance Registry System | 1,3-Isobenzofurandione, 3a,4,7,7a-tetrahydro-, (3aR,7aS)-rel- (935-79-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H317-H318-H334-H412 | |||||||||
| Precautionary statements | P261-P273-P280-P302+P352-P304+P340+P312-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 41-42/43-52/53 | |||||||||
| Safety Statements | 22-24-26-37/39-61-52/53-42/43-41 | |||||||||
| RIDADR | UN 2698 8/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GW5775000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29173990 | |||||||||
| NFPA 704 |
|
cis-1,2,3,6-Tetrahydrophthalic anhydride price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 136891 | cis-1,2,3,6-Tetrahydrophthalic anhydride 95% | 935-79-5 | 1kg | $53.82 | 2024-03-01 | Buy |
| Sigma-Aldrich | 136891 | cis-1,2,3,6-Tetrahydrophthalic anhydride 95% | 935-79-5 | 100g | $57.5 | 2023-06-20 | Buy |
| TCI Chemical | C0493 | cis-4-Cyclohexene-1,2-dicarboxylic Anhydride >98.0%(GC)(T) | 935-79-5 | 25g | $21 | 2024-03-01 | Buy |
| TCI Chemical | C0493 | cis-4-Cyclohexene-1,2-dicarboxylic Anhydride >98.0%(GC)(T) | 935-79-5 | 500g | $36 | 2024-03-01 | Buy |
| Alfa Aesar | B21431 | cis-4-Cyclohexene-1,2-dicarboxylic anhydride, 95% | 935-79-5 | 250g | $29.5 | 2024-03-01 | Buy |
cis-1,2,3,6-Tetrahydrophthalic anhydride Chemical Properties,Uses,Production
Description
Tetrahydrophthalic anhydride is an organic compound with the formula C6H8C2O3. The compound exists as two isomers, this article being focused on the more common cis isomer. It is a precursor to other compounds including the dicarboxylic acid tetrahydrophthalic acid as well the tetrahydrophthalimide, which is a precursor to the fungicide Captan. It is a white solid that is soluble in organic solvents.
Tetrahydrophthalic anhydride, the cis isomer, is prepared by the Diels-Alder reaction of butadiene and maleic anhydride.
Chemical Properties
Tetrahydrophthalic Anhydride (THPA) is a white crystalline powder or FLAKES. It is slightly soluble in benzene and acetone and it is also sensitive to moisture.
Uses
cis-1,2,3,6-Tetrahydrophthalic anhydride (THPA) can be used as:
- A curing agent for epoxides.
- A chemical modifier in the modification of polystyrene via Friedel-Crafts acylation for enhancing the thermal stability of the polymer.
- A reactant for the synthesis of cis-tetrahydroisoindole-1,3-dione derivatives and cyclic diimides.
Uses
Tetrahydrophthalic Anhydride is an anhydride hardener mainly used in the fields of coatings, epoxy resin curing agents, polyester resins, adhesives, plasticizers, pesticides, etc. It is also used as a chemical intermediate for light colored alkyds.
Tetrahydrophthalic Anhydride is an organic compound obtained from the reaction of Maleic Anhydride and Butadiene.
Preparation
A flask containing 500 ml of dry benzene and 196 gm (2 moles) of maleic anhydride is heated with a pan of hot water while butadiene is introduced rapidly (0.6-0.8 liter/min) from a commercial cylinder. The solution is stirred rapidly and the heating is stopped after 3-5 min when the temperature reaches 50°C. In 15-25 min the reaction causes the temperature of the solution to reach 70-75°C. The absorption of the rapid stream of butadiene is nearly complete in 30-40 min. The addition of butadiene is continued at a slower rate for a total of 2\ hr. The solution is poured into a 1-liter beaker which is covered and kept at 0-5°C overnight. The product is collected on a large Buchner funnel and washed with 250 ml of b.p. 35-60°C petroleum ether. A second crop is obtained by diluting the filtrate with an additional 250 ml of petroleum ether. Both crops are dried to constant weight in an oven at 70-80°C to yield 281.5-294.5 gm (96- 97%, m.p. 99-102°C). Recrystallization from ligroin or ether raises the melting point to 103-104°C.
Synthesis Reference(s)
Journal of the American Chemical Society, 64, p. 802, 1942 DOI: 10.1021/ja01256a018
cis-1,2,3,6-Tetrahydrophthalic anhydride Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Puyang Huicheng Electronic Materials Co., Ltd. | +86-0393-+86-0393-8910800 +8615839383373 | info@huichengchem.com | China | 516 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| AB PharmaTech,LLC | 323-480-4688 | United States | 989 | 55 | |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
View Lastest Price from cis-1,2,3,6-Tetrahydrophthalic anhydride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2023-04-18 | cis-1,2,3,6-Tetrahydrophthalic anhydride
935-79-5
|
US $30.00-10.00 / kg | 10kg | 99% | 100000kg | Hebei Guanlang Biotechnology Co,.LTD | |
 |
2021-08-10 | cis-1,2,3,6-Tetrahydrophthalic anhydride
935-79-5
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Guanlang Biotechnology Co., Ltd. | |
 |
2021-07-10 | Tetrahydrophthalic anhydride
935-79-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- cis-1,2,3,6-Tetrahydrophthalic anhydride
935-79-5
- US $30.00-10.00 / kg
- 99%
- Hebei Guanlang Biotechnology Co,.LTD
-
- cis-1,2,3,6-Tetrahydrophthalic anhydride
935-79-5
- US $10.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
-
- Tetrahydrophthalic anhydride
935-79-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd