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Gamma oryzanol

CAS No.
11042-64-1
Chemical Name:
Gamma oryzanol
Synonyms
GAMMA-ORYZANOL;oz;Gu Weisu;gammariza;Γ-ORYZANOL;.gamma.-Orizanol;hi-z;oliver;Caclate;gamma-oz
CBNumber:
CB5758140
Molecular Formula:
C40H58O4
Molecular Weight:
602.89
MDL Number:
MFCD00867548
MOL File:
11042-64-1.mol
Last updated:2024-03-28 13:39:29

Gamma oryzanol Properties

Melting point 135-137°C
Boiling point 571.92°C (rough estimate)
Density 0.9751 (rough estimate)
refractive index 1.4760 (estimate)
storage temp. Sealed in dry,Room Temperature
Water Solubility Practically insoluble in water
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form powder to crystaline
color White to Light yellow
Odor little or no odor
Merck 14,6886
LogP 13.205 (est)
CAS DataBase Reference 11042-64-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII SST9XCL51M

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H310
Precautionary statements  P501-P270-P262-P264-P280-P361+P364-P302+P352+P310-P405
RIDADR  UN 2811 6.1/PG II
RTECS  RN0050000
HS Code  3822.19.0080
HazardClass  6.1
PackingGroup  II
Toxicity LD50 oral in rat: > 25gm/kg
NFPA 704
0
3 0

Gamma oryzanol price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1479202 Gamma-Oryzanol United States Pharmacopeia (USP) Reference Standard 11042-64-1 50MG $447 2024-03-01 Buy
TCI Chemical O0172 γ-Oryzanol 11042-64-1 25g $56 2024-03-01 Buy
TCI Chemical O0172 γ-Oryzanol 11042-64-1 250g $270 2024-03-01 Buy
TRC O675500 γ-Oryzanol 11042-64-1 250g $250 2021-12-16 Buy
ChemScene CS-7898 γ-Oryzanol 11042-64-1 500mg $50 2021-12-16 Buy
Product number Packaging Price Buy
1479202 50MG $447 Buy
O0172 25g $56 Buy
O0172 250g $270 Buy
O675500 250g $250 Buy
CS-7898 500mg $50 Buy

Gamma oryzanol Chemical Properties,Uses,Production

Description

Gamma oryzanol is a lipid fraction derived from rice-bran oil. Oryzanol was first isolated from rice-bran oil in the 1950s. Several lipid fractions were isolated from the oil.The third (gamma) fraction isolated was oryzanol.It is made up of a mixture of ferulic acid esters and plant sterols. Similar in structure to cholesterol, the phytosterols and triterpenes that comprise oryzanol include campesterol, stigmasterol, beta sitosterol, cycloartanol, and cycloartenol. Because phytosterols are poorly absorbed, it has been suggested that they may reduce blood cholesterol by inhibiting intestinal cholesterol absorption.In contrast, the ferulic acid portion of gamma oryzanol is easily absorbed into the body's tissues. Ferulic acid also has demonstrated antioxidant properties in vitro.

Chemical Properties

White to Off-White Solid

Occurrence

Gamma oryzanol is found in rice-bran oil, which is commercially available in Japan for use in salad oils and frying.Crude rice-bran oil contains approximately 1.56% oryzanol.Of the 180 mg of plant sterols found in the typical American diet,about 4% is gamma-oryzanol.One cup of brown rice provides 18 mg gamma oryzanol, whereas white rice provides 4mg. The ferulic acid portion of gamma oryzanol is naturally found in the bran of cereals, and in fruits and vegetables.Ferulic acid is also a metabolite of caffeic acid found in coffee.

Uses

Gamma Oryzanol is a mixture of 6 substances derived from rice bran oil, including sterols and ferulic acid, called Cycloartanyl Ferulate or Triterpene alcohol ferulate. It has been approved in Japan for several conditions, including menopausal symptoms, mild anxiety, stomach upset, and high cholesterol. In the US, it is widely used as a sports supplement, as well as for reducing cholesterol. gamma oryzanol is widely used as a food additive, pharmaceutical material. In cosmetic area, the application to creams and sunscreens exploiting its skin age resistor function and ultraviolet absorbing effect.

Preparation

Extraction of gamma oryzanol from processes oil.
Gamma oryzanol can be extracted by liquid-liquid extraction method by using organic solvent or by using supercritical extraction method. The following procedure was followed to extract gamma oryzanol from the oil.
Rice Bran Oil (1 kg)→NaOH and water was added→Stirred and stored for one day at room temperature→Acidified to pH 4 using H2SO4→Heated to 80°C→50g NaCl was added→Oily layer was obtained→ Methanol was added→ Mixture was cooled to 0°C for 2 hrs.→ Waxy component precipitated→ Solution of 5g H2SO4 in 300 ml methanol→ Stored for one day→ Stirred at 40°C to remove/evaporate methanol→ To 100g residue 100g n-hexane was added→ Solvent Distillation→ Treatment of 100 ml methanol was given→ Residue was extracted 3 times with 50ml 0.5N→ methanolicNaOH→ Neutralised with methanolic acetic acid to pH 6.8-7→ Stored to precipitate gamma oryzanol.
The yield of gamma oryzanol was found to be 2.2%

Definition

ChEBI: Gamma-Oryzanol (TN) is a triterpenoid.

General Description

Gamma oryzanol is found in the by-products of the rice industry, such as rice bran and rice bran oil. It exhibits a wide range of biological activities, including anticarcinogenic, anti-inflammatory, antihyperlipidemic, and neuroprotective properties, which are primarily due to its high antioxidant capacity.

Side effects

Gamma oryzanol has no side effects for horses, dogs or humans.
Toxicity studies on animals demonstrate that gamma oryzanol is a very safe compound. No significant side-effects have been reported in human trials at the above noted recommended dosage.
Some research suggests that gamma oryzanol taken in moderately high amounts (up to 600 mg per day) for several months can cause dry mouth, sleepiness, hot flushes, irritability, and light headedness in some individuals.

Safety Profile

A poison by skin contact. Moderately toxic by intravenous route. Low toxicity by ingestion. Experimental reproductive effects. When heated to decompositionit emits acrid smoke and irritating vapors.

Dosage

A typical dosage of gamma oryzanol is 500 mg daily.

Gamma oryzanol Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 374)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd
+8613288715578 sales@hbmojin.com China 12452 58
Hangzhou ICH Biofarm Co., Ltd
+undefined8613073685410 sales@ichemie.com China 985 58
BINBO BIOLOGICAL CO.,LTD
+8618629063126 info@binbobiological.com China 42 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2989 55
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 alice@crovellbio.com China 8823 58
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58

View Lastest Price from Gamma oryzanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Gamma oryzanol pictures 2024-03-28 Gamma oryzanol
11042-64-1
US $0.00 / kg 1kg 99.8% 1000 kg BINBO BIOLOGICAL CO.,LTD
Gamma-Oryzanol pictures 2023-11-01 Gamma-Oryzanol
11042-64-1
US $0.00-0.00 / kg 1kg 97~103% 2tons Hangzhou ICH Biofarm Co., Ltd
Gamma oryzanol pictures 2023-08-05 Gamma oryzanol
11042-64-1
US $0.00-0.00 / kg 1kg 0.99 50000kg Hebei Yibangte Import and Export Co. , Ltd.
  • Gamma-Oryzanol pictures
  • Gamma-Oryzanol
    11042-64-1
  • US $0.00-0.00 / kg
  • 97~103%
  • Hangzhou ICH Biofarm Co., Ltd
  • Gamma oryzanol pictures
  • Gamma oryzanol
    11042-64-1
  • US $0.00-0.00 / kg
  • 0.99
  • Hebei Yibangte Import and Export Co. , Ltd.
gamma-orizanol gamma-oz Major coMpounds: Cycloartenylferulate and 24-Methylen Cycloartanylferulate Other coMpounds: CaMpesterylferulate, CaMpestanylferulate, β-Sitosterylferulate and Cycloartanylferulate gamma.-Orizanol Oryzanol hi-z oliver GAMMAORYZANOL,98%(BULK GAMMA-ORYZANOL,CRYSTALLINEPOWDER AMMA-ORYZANOL Gamma Oryzanol (Rice Bran) Extract Caclate Gammajust 50 g-Oryzanol Oryzanol, MIN. 20 MESH ORYZANOLUM γ-oryzanol γ-Oryzanol γ-Oryzanol Standard (2aR,3R,5aS,9S,11aR)-2a,5a,8,8-tetramethyl-3-((R)-6-methylhept-5-en-2-yl)tetradecahydro-1H,12H-cyclopenta[a]cyclopropa[e]phenanthren-9-yl (E)-3-(4-hydroxy-3-methoxyphenyl)acrylate gamma-Oryzanol USP/EP/BP Gamma Oryzanol Powder (+)-Xylose GAMMA-ORYZANOL .gamma.-Orizanol gammariza Gu Weisu oz Γ-ORYZANOL *Amphetamine Impurity 5 11042-64-1 11042-61-1 1042-64-1 C40H58O4 Plant extracts Aromatics Intermediates & Fine Chemicals Pharmaceuticals Steroids Nutritional Supplements Aromatic Esters