Efalizumab
- CAS No.
- 339155-58-7
- Chemical Name:
- Efalizumab
- Synonyms
- Xanelim;Raptiva;Hu 1124;Efalizumab;Unii-xx2mn88N5d
- CBNumber:
- CB5953693
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| FDA UNII | XX2MN88N5D |
|---|---|
| NCI Drug Dictionary | efalizumab |
| ATC code | L04AA21 |
Efalizumab Chemical Properties,Uses,Production
Uses
Treatment of transplant rejections; antipsoriatic (immunomodulator monoclonal antibody which decreases the activation, migration, and adhesion of T-cells). hu1124; anti-CD11a.
Efalizumab (Raptiva) is a humanized monoclonal antibody that binds to the CD11a subunit of LFA-1. It blocks the interaction of LFA-1 with ICAM-1, thereby interfering with T-cell activation and trafficking. Efalizumab is FDA approved at 1.0 mg/kg/week by subcutaneous injection. Common side effects include mild headache, fever, chills, nausea, or myalgia within the first 48 hours of injection in the first 2 to 3 weeks of therapy. Immune-mediated thrombocytopenia is rare. Worsening of psoriasis may occur after discontinuation of therapy or in unresponsive patients during therapy. Transitioning patients to alternative therapies may minimize this risk.
Pharmacology
Efalizumab (Raptiva) is a humanized monoclonal antibody that binds to the CD11a subunit of LFA-1. It blocks the interaction of LFA-1 with ICAM-1, thereby interfering with T-cell activation and trafficking. Efalizumab is FDA approved at 1.0 mg/kg/week by subcutaneous injection.
Side effects
Common side effects include mild headache, fever, chills, nausea, or myalgia within the first 48 hours of injection in the first 2 to 3 weeks of therapy. Immune-mediated thrombocytopenia is rare. Worsening of psoriasis may occur after discontinuation of therapy or in unresponsive patients during therapy. Transitioning patients to alternative therapies may minimize this risk.
Efalizumab Preparation Products And Raw materials
Raw materials
Preparation Products
Efalizumab Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12338 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10055 | 58 |
| Supplier | Advantage |
|---|---|
| Beijing HuaMeiHuLiBiological Chemical | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 58 |