ATC 0175
- CAS No.
- 510733-97-8
- Chemical Name:
- ATC 0175
- Synonyms
- ATC 0175 hydrochloride;N-[cis-4-[[4-(Dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluorobenzamidehydrochloride
- CBNumber:
- CB5972935
- Molecular Formula:
- C23H25F2N5O.ClH
- Molecular Weight:
- 461.941
- MDL Number:
- MFCD08276913
- MOL File:
- 510733-97-8.mol
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: soluble5mg/mL |
| form | solid |
| FDA UNII | 4359628TE8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335-H413 |
| Precautionary statements | P273-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
ATC 0175 price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A3355 | ATC0175 ≥98% (HPLC), solid | 510733-97-8 | 10mg | $499 | 2024-03-01 | Buy |
| Tocris | 3346 | ATC0175hydrochloride ≥98%(HPLC) | 510733-97-8 | 50 | $897 | 2021-12-16 | Buy |
| Tocris | 3346 | ATC0175hydrochloride ≥98%(HPLC) | 510733-97-8 | 10 | $220 | 2021-12-16 | Buy |
| TRC | A790540 | ATC0175 | 510733-97-8 | 10mg | $265 | 2021-12-16 | Buy |
| Usbiological | 254689 | ATC 0175 hydrochloride | 510733-97-8 | 10mg | $489 | 2021-12-16 | Buy |
ATC 0175 Chemical Properties,Uses,Production
Uses
ATC0175 is a MCHR1, SR-1A and SR-2B inhibitor.
Biological Activity
Potent, selective and orally active melanin-concentrating hormone receptor 1 (MCH 1 ) antagonist (IC 50 values are 13.5 and > 10000 nM for MCH1 and MCH2 receptors respectively). Exhibits anxiolytic and antidepressant activity in rodents. Also displays affinity for 5-HT 2B and 5-HT 1A receptors (IC 50 values are 9.66 and 16.9 nM respectively).
in vitro
assays showed that this compound is a potent antagonist with a high affinity for mch1r. the receptor binding and the functional assay (mch-induced increase in [ca2+]) indicated that atc0175 is a noncompetitive antagonist at mch1rs 1.
in vivo
atc0175 displayed anxiolytic effects in numerous animal models of anxiety including the social interaction test, elevated plus-maze test, maternal separation-induced vocalization and stress-induced hyperthermia. in addition, atc0175 treatment also exhibited antidepressant effects in the forced swimming test 2.
References
1. semple g, tran ta, kramer b, et al. pyrimidine-based antagonists of h-mch-r1 derived from atc0175: in vitro profiling and in vivo evaluation. bioorganic & medicinal chemistry letters. 2009;19(21):6166-6171.2. chaki s, yamaguchi j, yamada h, et al. atc0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. cns drug reviews. 2005;11(4):341-352.
ATC 0175 Preparation Products And Raw materials
Raw materials
Preparation Products
ATC 0175 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9767 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-0512-13601744364 13601744364 | chemsharker@126.com | China | 879 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |