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2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE

CAS No.
64048-12-0
Chemical Name:
2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE
Synonyms
¥GANT58;,4¥4,4¥Nsc75503;GANT58 (NSC 75503);Hh/Gli Antagonist, GANT58;2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE;1,2,3,4-Tetrakis(4-pyridyl)thiophene;2,3,4,5-Tetra - (4-pyridine) thiophene
CBNumber:
CB6113191
Molecular Formula:
C24H16N4S
Molecular Weight:
392.48
MDL Number:
MFCD01103196
MOL File:
64048-12-0.mol
MSDS File:
SDS
Last updated:2023-09-20 16:43:00

2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE Properties

Melting point 252-253℃
Boiling point 414.1±40.0 °C(Predicted)
Density 1.254
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility DMSO: >10mg/mL
form Yellow solid
pka 4.50±0.10(Predicted)
color white to pale yellow

SAFETY

Risk and Safety Statements

WGK Germany  3

2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich G8923 GANT58 ≥98% (HPLC) 64048-12-0 5mg $127 2024-03-01 Buy
Sigma-Aldrich 373400 Hh/Gli Antagonist, GANT58 64048-12-0 5mg $294 2024-03-01 Buy
Cayman Chemical 14193 GANT 58 ≥98% 64048-12-0 5mg $72 2024-03-01 Buy
Cayman Chemical 14193 GANT 58 ≥98% 64048-12-0 10mg $121 2024-03-01 Buy
Sigma-Aldrich G8923 GANT58 ≥98% (HPLC) 64048-12-0 25mg $394 2024-03-01 Buy
Product number Packaging Price Buy
G8923 5mg $127 Buy
373400 5mg $294 Buy
14193 5mg $72 Buy
14193 10mg $121 Buy
G8923 25mg $394 Buy

2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE Chemical Properties,Uses,Production

Uses

GANT 58 is an inhibitor of GLI1-induced transcription. This affects the functional aspects of cell growth, differentiation and activation. The modulatory ability of this drug is critical to maintenance of self-tolerance, immune suppression and tumor immunosurvelliance involved in T regulatory cells. GANT58 also inihibits hedgehog signalling inducing apoptosis in acute T cell leukemia cells.

Definition

ChEBI: 4-(2,4,5-tripyridin-4-yl-3-thiophenyl)pyridine is a member of pyridines.

Biological Activity

gant 58 is an antagonist of gli that inhibits gli1-induced transcription with an ic50 value of 5 μm [1].gli1 is a human glioblastoma isolated protein which belongs to gli protein family. gli proteins act as effectors in hedgehog signaling pathway and get involved in cell proliferation, determination and patterning during embryo development.gant 58 is considered to inhibit gli1-mediated gene trans-activation with a high selectivity for hedgehog signaling pathway. when tnf signaling/nfkb activation, glucocorticoid, receptor gene transactivation, and the ras-raf-mek-mapk cascade were treated with gant 58, no inhibition was observed. when sag-treated shh-l2 cells were treated with 10 μm gant 58 for 48 hr, the reduction of hedgehog pathway signaling was observed, whereas gli1 mrna level reduction was induced by the treatment of 10 μm gant 58 for 2-3 days. indeed, gant 58 was confirmed as inhibitor of hedgehog signaling pathway downstream sufu and smo [1]. furthermore, gant 58 treatments for 48 hr resulted in the significant reduction of cell viability in a dose-dependent manner for ccrfecem, cem7e14, cem1e15 and jurkat cells. when ccrfecem cells were treated with 10 μm gant 58 for 48 hr, the percentage of cells in g1/s phase increased whereas the percentage in g2/m phase decreased [2].in mouse model with xenograft, daily s.c. injection of gant 58 resulted in significant suppression of tumor cell growth. 50 mg/kg/d gant 58 injections for 18 days induced the suppression of additional xenograft growth and restrict the increase of tumor size. no side effects were observed during the treatment [1].

storage

+4°C

13362-78-2
64048-12-0
Synthesis of 2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE from 4,4'-Vinylenedipyridine

2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE Preparation Products And Raw materials

2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE Suppliers

Global( 105)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Zhengzhou Alfa Chemical Co.,Ltd
+8618530059196 sale04@alfachem.cn China 12333 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
LEAP CHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 24738 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 132020 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 6013 61

View Lastest Price from 2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GANT 58 pictures 2020-01-13 GANT 58
64048-12-0
US $1.00 / g 1g 95-99% 1ton Career Henan Chemical Co
  • GANT 58 pictures
  • GANT 58
    64048-12-0
  • US $1.00 / g
  • 95-99%
  • Career Henan Chemical Co

64048-12-0(2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE)Related Search:

¥ -(2,3,4,5-Thiophentetrayl)tetrakis-pyridine ,4¥ 4,4¥ Nsc75503 Pyridine, 4,4',4'',4'''-(2,3,4,5-thiophenetetrayl)tetrakis- GANT58 1,2,3,4-Tetrakis(4-pyridyl)thiophene 4,4',4'',4'''-(2,3,4,5-THIOPHENTETRAYL)TETRAKIS-PYRIDINE 2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE 4,4',4'',4'''-(2,3,4,5-Thiophenetetrayl)tetrakispyridine 4,4′,4′′,4′′′-Thiene-2,3,4,5-tetrayltetrapyridine 4,4',4'',4'''-(thiophene-2,3,4,5-tetrayl)tetrapyridine Hh/Gli Antagonist, GANT58 Hh/Gli Antagonist, GANT58 - CAS 64048-12-0 - Calbiochem GANT58 (2,3,4,5-Tetra(4-pyridyl)thiophene GANT58 (NSC 75503) 2,3,4,5-Tetra - (4-pyridine) thiophene 64048-12-0 C24H16N4S