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Sulfathiazole

CAS No.
72-14-0
Chemical Name:
Sulfathiazole
Synonyms
ST;NORSULFAZOLE;Sulphathiazole;Norsulfazol;SULFATHIAZOL;Sulfathiazloe;Duatok;Dulana;m&b760;m+b760
CBNumber:
CB6133470
Molecular Formula:
C9H9N3O2S2
Molecular Weight:
255.32
MDL Number:
MFCD00005319
MOL File:
72-14-0.mol
MSDS File:
SDS
Last updated:2024-03-28 16:55:20

Sulfathiazole Properties

Melting point 200-202 °C (lit.)
Boiling point 479.5±47.0 °C(Predicted)
Density 1.4629 (rough estimate)
refractive index 1.6560 (estimate)
storage temp. 2-8°C
solubility 0.5g/l
pka 7.2(at 25℃)
color White
Water Solubility Insoluble (<0.1 g/100 mL at 21 ºC)
Merck 14,8943
BRN 226178
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey JNMRHUJNCSQMMB-UHFFFAOYSA-N
CAS DataBase Reference 72-14-0(CAS DataBase Reference)
FDA UNII Y7FKS2XWQH
ATC code D06BA02,J01EB07
NIST Chemistry Reference Sulfathiazole(72-14-0)
EPA Substance Registry System Sulfathiazole (72-14-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335-H412
Precautionary statements  P261-P264-P271-P273-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
RIDADR  3249
WGK Germany  2
RTECS  WP2360000
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29350090
NFPA 704
1
2 0

Sulfathiazole price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.21112 N1-2-Thiazolylsulfanilamid for synthesis 72-14-0 5G $36.4 2024-03-01 Buy
Sigma-Aldrich 8.21112 N1-2-Thiazolylsulfanilamid for synthesis 72-14-0 250g $113 2024-03-01 Buy
Sigma-Aldrich 46902 Sulfathiazole VETRANAL?, analytical standard 72-14-0 250mg $62.1 2024-03-01 Buy
Sigma-Aldrich 1636504 Sulfathiazole United States Pharmacopeia (USP) Reference Standard 72-14-0 350mg $436 2024-03-01 Buy
TCI Chemical S0272 Sulfathiazole >98.0%(HPLC)(T) 72-14-0 25g $78 2024-03-01 Buy
Product number Packaging Price Buy
8.21112 5G $36.4 Buy
8.21112 250g $113 Buy
46902 250mg $62.1 Buy
1636504 350mg $436 Buy
S0272 25g $78 Buy

Sulfathiazole Chemical Properties,Uses,Production

Chemical Properties

white to cream powder

Originator

Tiazol,C. and C.

Uses

Antibacterial.This compound is a contaminant of emerging concern (CECs).

Uses

Sulfonamide antibacterial.

Definition

ChEBI: A 1,3-thiazole compound having a 4-aminobenzenesulfonamido group at the 2-position.

Manufacturing Process

116 parts 4-acetamidobenzolsufonyl chloride (prepared from acetanilide and chlorosulfonic acid) was mixed with 100 parts 2-aminothiasole in 1000 parts water by cooling and stirred for some hours. The bis-amide obtained was filtered off and re-crystallized from 50% ethanol to give bis-(pacetylaminobenzolsulfo)- 2-aminothiazol with MP: 129°C.
10 parts above bis-amide was heated with 10% sodium hydroxide solution for 0.5 hour on water bath. On cooling and filtration the alkaline solution was acidified with glacial acetic acid. The amide obtained was cleared by recrystallized from water to give N1-2-thiazolylsulfanilamide; MP: 202°-203°C.

brand name

Argazol;Bucosol;Chemiovis;Coryza;Crionil;Csp 500;Csp-250;Edifeno;Femakzem;Formotablin antidiarreico;Gyne-sulf;Gyn-sulf;Neosutrin;Polvos wilfe;Pomada wilfe;Prothiazol;Septex cream no. 2;Streptacillin;Sulfa-orzon;Sulfazol;Sulfhatose;Sulfintestin;Sulfopyrol;Sulfour;Sulfzol;Sulnac;Sulphatriad;Tampovagan pss;Thiadyl;Thiuramide;Tiadyl;Trimeto;Trisulpha;Trysul;Tylasul;Ufa 902-duo;Vetoprim mi;Wintrazol.

Therapeutic Function

Antibacterial

World Health Organization (WHO)

Sulfathiazole, a sulfonamide anti-infective agent, was introduced more than 25 years ago for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Although preparations remain available, use of the drug has been discontinued in many countries.

General Description

White crystalline powder. Is dimorphous: form I is consists of prismatic rods and form II of six-sided plates and prisms. Insoluble in water and soluble in dil aqueous acid and aqueous base.

Air & Water Reactions

May be sensitive to heat, air and light during long-term storage . Insoluble in water.

Reactivity Profile

Sulfathiazole is an amino acid.

Fire Hazard

Flash point data for Sulfathiazole are not available, but Sulfathiazole is probably combustible.

Pharmaceutical Applications

2-Sulfanilamidothiazole. A short-acting compound (half-life c. 4 h) with relatively high activity. Protein binding is c. 75%. Its use has declined because of a high incidence of side effects. It is one of the constituents of triple sulfonamide mixtures, of which local preparations are still available.
Two compounds, phthalylsulfathiazole (sulfathalidine) and succinylsulfathiazole (sulfasuxidine) owe their activity to the slow liberation of sulfathiazole in the bowel. They are poorly soluble and very little is absorbed after oral administration. They were formerly used in the treatment of intestinal infections and in bowel preparation before surgery. They are available in multi-ingredient preparations in some countries.

Biochem/physiol Actions

Sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase.Mode of Action: Inhibits folic acid synthesis in prokaryotes.Anti-microbial Spectrum: Gram positive, Gram negative, ChlamydiaMode of Resistance: Alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Safety Profile

Human poison by unspecified route. Experimental poison by intraperitoneal route, Moderately toxic by intravenous, subcutaneous, and parenteral routes. Mildly toxic by ingestion. Human systemic effects by unspecified route: conjunctiva irritation, tubule changes, and allergic skin dermatitis. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data, Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx.

96-50-4
121-60-8
72-14-0
Synthesis of Sulfathiazole from 2-Aminothiazole and N-Acetylsulfanilyl chloride

Sulfathiazole Preparation Products And Raw materials

Global( 450)Suppliers
Supplier Tel Email Country ProdList Advantage
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2989 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293 sales@sdzschem.com China 2931 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 alice@crovellbio.com China 8823 58
Shandong chuangyingchemical Co., Ltd.
18853181302 sale@chuangyingchem.com CHINA 5909 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213 info@longyupharma.com China 2530 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63711 58

View Lastest Price from Sulfathiazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sulfathiazole pictures 2024-03-28 Sulfathiazole
72-14-0
US $0.00 / KG 1KG 99% 2000KG Shaanxi TNJONE Pharmaceutical Co., Ltd
Sulfathiazole pictures 2024-03-16 Sulfathiazole
72-14-0
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Sulfathiazole pictures 2023-03-06 Sulfathiazole
72-14-0
US $5.00 / Kg/Bag 10g 99 % 10000kg Hebei Guanlang Biotechnology Co,.LTD
  • Sulfathiazole pictures
  • Sulfathiazole
    72-14-0
  • US $0.00 / KG
  • 99%
  • Shaanxi TNJONE Pharmaceutical Co., Ltd
  • Sulfathiazole pictures
  • Sulfathiazole
    72-14-0
  • US $0.00 / KG
  • 98%+
  • WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
  • Sulfathiazole pictures
  • Sulfathiazole
    72-14-0
  • US $5.00 / Kg/Bag
  • 99 %
  • Hebei Guanlang Biotechnology Co,.LTD
4-amino-n-2-thiazolyl-benzenesulfonamid Azoquimiol Azoseptale Benzenesulfonamide, 4-amino-N-2-thiazolyl- Cerazol Cerazol (suspension) cerazol(suspension) Cerazole Chemosept Ciba 3714 ciba3714 Cibazol Coco-Thiazole Duatok Dulana Eleudron Enterobiocine Estafilol Formosulfathiazole M&B 760 m&b760 M+B 760 m+b760 n(1)-2-thiazolyl-sulfanilamid N(Sup1)-(2-Thiazolyl)sulfanilamide n(sup1)-2-thiazolyl-sulfanilamid n(sup1)-2-thiazolylsulfanilamide Neostrepsan Norsulfasol Planomide Poliseptil RP 2090 rp2090 Sanotiazol Septozol Streptosilthiazole Sulfamul Sulfanilamide, N(sup1)-2-thiazolyl- Sulfanilamide, N1-2-thiazolyl- 2-SULFANILAMIDOTHIAZOLE 2-(SULFANILAMINO)THIAZOLE 2-(4-AMINOBENZENESULFONAMIDO)THIAZOLE 2-(P-AMINOBENZENESULFONAMIDO)THIAZOLE Sulfanilamide, N1-4-thiazolin-2-ylidene- Sulfanilamidothiazole Sulfathiazole(form1) Sulfathiazole(form3) sulfathiazone Sulfavitina Sulfocerol Sulzol Thiacoccine Thiasulfol Thiozamide USAF sn-9 usafsn-9 Wintrazole SULFATHIAZOLE