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Salinomycin

Salinomycin structure

CAS No.: 55721-31-8

Chemical Name:: Salinomycin

Synonyms: Salinomycin;Salinomycin Na;Salinomycin-Natrium;Glycerol Impurity 109;Salomycin sodium salt;Salinomycin 1-sodium salt;Salinomycin sodium premix;Salinomycin, monosodium salt;Salinomycin, sodiumsalt (1:1);Salinomycin sodium (Procoxacin)

CBNumber:: CB6161783

Molecular Formula:: C42H71NaO12

Molecular Weight:: 791

MDL Number:: MFCD00145265

MOL File:: 55721-31-8.mol

Last updated:2024-04-25 17:59:01

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Salinomycin Properties

Melting point	140-142°
alpha	D25 -37° (c = 1 in ethanol)
storage temp.	APPROX 4°C
solubility	Soluble in DMSO.
color	White
Merck	13,8415
BRN	4901827
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
FDA 21 CFR	556.592; 558.550
EWG's Food Scores	1
FDA UNII	92UOD3BMEK

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P264-P270-P301+P310-P405-P501
Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	2811
WGK Germany	3
HazardClass	6.1
PackingGroup	III

Salinomycin price More Price(14)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	13579	Salinomycin (sodium salt) ≥90%	55721-31-8	5mg	$13	2021-12-16	Buy
Cayman Chemical	13579	Salinomycin (sodium salt) ≥90%	55721-31-8	10mg	$23	2021-12-16	Buy
Cayman Chemical	13579	Salinomycin (sodium salt) ≥90%	55721-31-8	50mg	$78	2021-12-16	Buy
Cayman Chemical	13579	Salinomycin (sodium salt) ≥90%	55721-31-8	100mg	$130	2021-12-16	Buy
TRC	S088805	SalinomycinSodiumSalt	55721-31-8	250mg	$870	2021-12-16	Buy

Product number	Packaging	Price	Buy
13579	5mg	$13	Buy
13579	10mg	$23	Buy
13579	50mg	$78	Buy
13579	100mg	$130	Buy
S088805	250mg	$870	Buy

Salinomycin Chemical Properties,Uses,Production

Chemical Properties

White or light yellow crystalline powder, slight specific smell, melting point 140-142 ℃. Soluble in acetone, chloroform, benzene, ethyl acetate, diethyl ether and methanol, almost insoluble in water. Rats by oral LD5070-100mg/kg, mice orally LD5050mg/kg, chicken LD50150mg/kg.

Uses

Salinomycin is safe and effective coccidiostat,which has inhibitory effect on most Gram-positive bacteria ,it also has effect on chicken coccidiosis, soft Ehrlich, Ehrlich poison, giant Ehrlich, Ehrlich and heap-shaped ball Harrington insects. It can be used for chicken feed, the amount is 50-60g/t,it should be stopped during laying period, the period is 5 days. Equine animals are hanged, it causes death after use; and it is banned using it with tiamulin, oleandomycin simultaneously.
The above information is edited by the chemicalbook of Tian Ye.

production method

It is produced by fermentation of white Streptomyces (Streptomyces albus).

Description

Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma.1?Salinomycin Na displays selective toxicity for cancer stem cells.1?Induces rapid mitochondrial hyperpolarization.2?Induces selective cytotoxicity to MCF-7 mammosphere cells via the hedgehog signaling pathway.3?Salinomycin Na reduces doxorubicin resistance of breast tumor cells by inhibiting drug efflux pump expression and activity.4?Kills cancer stem cells by sequestering iron.5

Chemical Properties

Brown Solid

Uses

Salinomycin is an ionophore agent.

Uses

Salinomycin sodium is prepared from salinomycin taking advantage of the acidic carboxylic acid which ionises and readily forms the salt in sodium hydroxide solutions. The sodium salt is the preferred formulation in animals to prevent coccidiosis and to promote growth. Salinomycin has a high affinity for monovalent cations, particularly potassium. Recently, salinomycin has been shown to inhibit cancer stem cells.

References

1) Gupta?et al. (2009),?Identification of selective inhibitors of cancer stem cells by high-throughput screening; Cell,?138?645 2) Manago?et al. (2015),?Early effects of the antineoplastic agent salinomycin on mitochondrial function; Cell Death Dis.,?6?e1930 3) Fu?et al. (2016),?Salinomycin induces selective cytotoxicity to MCF-7 mammosphere cells through targeting the Hedgehog signaling pathway;?Oncol. Rep.,?35?912 4)?Kim?et al.?(2015), Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin;?Mol. Med. Rep.,?12(2)?1898 5) Mai et al. (2017)?Salinomycin kills cancer stem cells by sequestering iron in lysosomes; Nat. Chem.,?9?1025

Salinomycin Preparation Products And Raw materials

Raw materials

Ammonium L-tartrate

Preparation Products

Salinomycin Suppliers

Global( 138)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618740459177	sarah@tnjone.com	China	893	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	+8617702722807	admin@hbouhuang.com	China	2259	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8823	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	1015@dideu.com	China	2263	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Hebei Guanlang Biotechnology Co., Ltd.	58
Xiamen AmoyChem Co., Ltd	58
Hubei xin bonus chemical co. LTD	58
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
SIMAGCHEM CORP	58

View Lastest Price from Salinomycin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-25	Salinomycin sodium salt 55721-31-8	US $15.00 / kg	1kg	99.912%	10ton	Ouhuang Engineering Materials (Hubei) Co., Ltd
2024-04-11	Salinomycin Sodium 55721-31-8	US $0.00 / kg	1kg	99%	100kg	Shaanxi TNJONE Pharmaceutical Co., Ltd
2024-04-11	Salinomycin Sodium 55721-31-8	US $0.00 / kg	1kg	99%	100kg	Shaanxi TNJONE Pharmaceutical Co., Ltd

Salinomycin sodium salt
55721-31-8
US $15.00 / kg
99.912%
Ouhuang Engineering Materials (Hubei) Co., Ltd

Salinomycin Sodium
55721-31-8
US $0.00 / kg
99%
Shaanxi TNJONE Pharmaceutical Co., Ltd

Salinomycin Sodium
55721-31-8
US $0.00 / kg
99%
Shaanxi TNJONE Pharmaceutical Co., Ltd

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SALINOMYCIN SODIUM SALT 2.5-HYDRATE SALINOMYCIN SV SODIUM SALT 2,5-HYDRATE Salinomycin hydrate monosodium salt Salinomycin sodium premix Salinomycin, monosodium salt salinomycin monosodium salt hydrate Salinomycin-Natrium (2R)-2-[(5S,6R)-6-[(2S,3S,4S,6R)-6-[(2S,5R,7S,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butanoic acid Salinomycin Salinomycin 1-sodium salt SalinoMycin SodiuM Salt (12% Min.) SalinoMycin 12% 24% HOUSE STANDARD 3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate Salinomycin Na Salinomycin sodium (Procoxacin) (2R)-2-[(2R,5S,6R)-6-[(3S,5S,7R,9S,10S,12R,15R)-3-[(2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butanoic acid soldium salt SALINOMYCIN SODIUM SALT (SALINOMYCIN SODIUM) Salinomycin, sodiumsalt (1:1) Glycerol Impurity 109 Salomycin sodium salt 55721-31-8 C42H70O11Na Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals S SA - SM Organics Antibiotics BactericidalAntibiotics Chemical Structure OthersAlphabetic Principle