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2,4-Dichloropyrimidine

2,4-Dichloropyrimidine structure

CAS No.: 3934-20-1

Chemical Name:: 2,4-Dichloropyrimidine

Synonyms: 2,4-dichloropyrimidine hydrochloride;2,4DCPY;NSC 20212;NSC 37531;NSC 49119;AKOS 91058;2,4-Dichlorpyrimidin;2,4-Dichloropyrimidi;4-DichloropyriMidine;Pazopanib Impurity 45

CBNumber:: CB6202781

Molecular Formula:: C4H2Cl2N2

Molecular Weight:: 148.98

MDL Number:: MFCD00006061

MOL File:: 3934-20-1.mol

MSDS File:: SDS

Last updated:2024-03-29 15:38:01

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2,4-Dichloropyrimidine Properties

Melting point	57-61 °C (lit.)
Boiling point	101 °C/23 mmHg (lit.)
Density	1.6445 (rough estimate)
refractive index	1.6300 (estimate)
Flash point	101°C/23mm
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	Powder, Crystals and/or Chunks
pka	-2.84±0.20(Predicted)
color	White to yellow to beige or grayish
Water Solubility	Soluble in water (partly), methanol, chloroform, and ethyl acetate.
Sensitive	Moisture Sensitive
BRN	110911
InChIKey	BTTNYQZNBZNDOR-UHFFFAOYSA-N
CAS DataBase Reference	3934-20-1(CAS DataBase Reference)
FDA UNII	YV96122OCD
NIST Chemistry Reference	Pyrimidine, 2,4-dichloro-(3934-20-1)
EPA Substance Registry System	Pyrimidine, 2,4-dichloro- (3934-20-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-28A

RIDADR

1759

WGK Germany

TSCA

Yes

HazardClass

PackingGroup

III

HS Code

29335990

NFPA 704

	1
2		0

2,4-Dichloropyrimidine price More Price(45)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	143847	2,4-Dichloropyrimidine 98%	3934-20-1	10g	$84.2	2024-03-01	Buy
Sigma-Aldrich	143847	2,4-Dichloropyrimidine 98%	3934-20-1	50g	$306	2024-03-01	Buy
TCI Chemical	D2310	2,4-Dichloropyrimidine >98.0%(GC)	3934-20-1	5g	$39	2024-03-01	Buy
TCI Chemical	D2310	2,4-Dichloropyrimidine >98.0%(GC)	3934-20-1	25g	$113	2024-03-01	Buy
Alfa Aesar	A15131	2,4-Dichloropyrimidine, 98+%	3934-20-1	5g	$50.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
143847	10g	$84.2	Buy
143847	50g	$306	Buy
D2310	5g	$39	Buy
D2310	25g	$113	Buy
A15131	5g	$50.65	Buy

2,4-Dichloropyrimidine Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

2,4-Dichloropyrimidine was used in the synthesis of medicinally important 4-aryl-5-pyrimidinylimidazoles.

Preparation

Obtained by chlorination of uracil. Add uracil, phosphorus trichloride, and xylene amine into the reaction pot, heat to 130 ℃, reflux for about 45min, slightly cool, put in crushed ice, that is, the precipitation of purple solid, filtered while hot and not dissolved, washed with ice water, vacuum drying, a kind of purple crude, decolorized with petroleum ether (boiling range of 60-90 ℃), recrystallized, obtained 2,4-dichloropyrimidine.

General Description

2,4-Dichloropyrimidine is a human skin sensitizer. It undergoes effective one-pot, regioselective double Suzuki coupling reaction to yield diarylated pyrimidines.

Reactivity Profile

The reaction of N-substituted cyclic amines with 2,4-dichloroquinazoline and 2,4-dichloro-5-methyl-pyrimidine afforded 2-amino-4-chloroquinazolines and 2-amino-4-chloro-5-methylpyrimidines, respectively—the reaction of these amines with 2,4-dichloropyrimidine 3a afforded not only 2-amino-4-chloropyrimidines but also the isomeric 4-amino-2-chloropyrimidines. An effective one-pot, regioselective double Suzuki coupling of 2,4-dichloropyrimidine has been developed. This method enables the quick and efficient synthesis of diarylated pyrimidines. The choice of solvent proved critical to the success of this reaction sequence, with alcoholic solvent mixtures affording much greater reactivity and correspondingly lower temperatures than polar aprotic solvents[5-6].

References

[1] DR. AGNES FIZIA. Cyclopalladation in the Periphery of a NHC Ligand as the Crucial Step in the Synthesis of Highly Active Suzuki–Miyaura Cross-Coupling Catalysts[J]. Chemistry - A European Journal, 2017. DOI:10.1002/chem.201702877.
[2] FABIAN BRUENING Lucie E L. Highly Regioselective Organocatalytic SNAr Amination of 2,4-Dichloropyrimidine and Related Heteroaryl Chlorides[J]. European Journal of Organic Chemistry, 2017. DOI:10.1002/ejoc.201700459.
[3] ANDERSONSAMANTHA C HandyScott T. One-pot Double Suzuki Couplings of Dichloropyrimidines.[J]. Synthesis-Stuttgart, 2010. DOI:10.1055/s-0030-1258150.
[4] TOMá? KUBELKA. Synthesis of 2,4-Disubstituted Pyrimidin-5-yl C-2′-Deoxyribonucleosides by Sequential Regioselective Reactions of 2,4-Dichloropyrimidine Nucleosides[J]. European Journal of Organic Chemistry, 2010. DOI:10.1002/ejoc.201000164.
[5] Kenji Yoshida, M. Taguchi. “Reaction of N-substituted cyclic amines with 2,4-dichloroquinazoline, 2,4-dichloropyrimidine, and its 5-methyl derivative.” Journal of The Chemical Society-perkin Transactions 1 102 1 (1992): 919–922.
[6] Samantha C Anderson, Scott T Handy. “One-pot Double Suzuki Couplings of Dichloropyrimidines.” Synthesis-Stuttgart 2010 16 (2010): 2721–2724.

2,4-Dichloropyrimidine synthesis

Synthesis of 2,4-Dichloropyrimidine from Uracil

2,4-Dichloropyrimidine Preparation Products And Raw materials

Raw materials

Phosphorus oxychloride Uracil Xylidine

Preparation Products

5-FORMYL-2,4-DIMETHOXYPYRIMIDINE (E)-5-(2-CARBOXYVINYL)-2,4-DIMETHOXYPYRIMIDINE 2,4-DIETHOXYPYRIMIDINE 2,4-Dimethoxypyrimidine 4-Hydroxypyrimidine

Chlorimuron-ethyl 4-BENZYLOXY-2-CHLOROPYRIMIDINE 5-Iodo-2,4-dimethoxypyrimidine 4-Amino-2-chloropyrimidine 2-CHLORO-4-(N,N-DIMETHYLAMINO)PYRIMIDINE

2-Chloro-4-hydrazinopyrimidine 2-CHLORO(BROMO)PYRIMIDINE N4-Methylcytosine 2-CHLORO-4-METHOXYPYRIMIDINE 2,4-DIFLUOROPYRIMIDINE

4-(3-Pyridyl)-2-chloropyrimidine Benzyl-(2-chloro-pyrimidin-4-yl)-methyl-amine Phenol, 5-[(2-chloro-4-pyrimidinyl)amino]-2-methyl-

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2,4-Dichloropyrimidine Suppliers

Global( 808)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
AstaTech(Chengdu) Biopharmaceutical Corp.	+86-02882666559 +86-15884417729	gjpu@astatech.com.cn	China	308	58
TCI AMERICA	800-4238616	sales@tciamerica.com	Americas	23662	75
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	1000	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7786	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	885	50
Springchem New Material Technology Co.,Limited	+86-021-62885108 +8613917661608	info@spring-chem.com	China	2068	57
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55

Supplier	Advantage
AstaTech(Chengdu) Biopharmaceutical Corp.	58
TCI AMERICA	75
Hebei Mojin Biotechnology Co., Ltd	58
Shaanxi Haibo Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Springchem New Material Technology Co.,Limited	57
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55

View Lastest Price from 2,4-Dichloropyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-12	2, 4-Dichloropyrimidine 3934-20-1	US $0.00 / kg	1kg	99%	2000ton	Shaanxi Haibo Biotechnology Co., Ltd
2024-03-29	2,4-Dichloropyrimidine 3934-20-1	US $6.00-0.20 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2023-08-31	2,4-Dichloropyrimidine 3934-20-1	US $100.00 / kg	1kg	99	5000	Hebei Fengqiang Trading Co., LTD

2, 4-Dichloropyrimidine
3934-20-1
US $0.00 / kg
99%
Shaanxi Haibo Biotechnology Co., Ltd

2,4-Dichloropyrimidine
3934-20-1
US $6.00-0.20 / KG
99%
Henan Fengda Chemical Co., Ltd

2,4-Dichloropyrimidine
3934-20-1
US $100.00 / kg
99
Hebei Fengqiang Trading Co., LTD

2,4-Dichloropyrimidine Spectrum

2,4-Dichloropyrimidine(3934-20-1)¹HNMR 2,4-Dichloropyrimidine(3934-20-1)IR1 2,4-Dichloropyrimidine(3934-20-1)Raman

3934-20-1(2,4-Dichloropyrimidine)Related Search:

4,6-Dichloropyrimidine ,98%,4 6-DICHLOROPYRIMIDINE 99% 2-Amino-4,6-dimethylpyrimidine 2-Amino-4,6-dimethoxypyrimidine 3-Methyl-6-nitroindazole 2-Ethyl-5-nitrobenzenamine ,98%

5-Amino-2-methylbenzenesulfonamide N4-(2,3-Dimethyl-2H-indazol-6-yl)-N4-methyl-2,4-pyrimidinediamine 3-methyl-1H-indazol-6-amine 5-Amino-2,3-dimethyl-2H-indazole Pazopanib Impurity 32

Benzenamine, 2-ethyl-4-nitro- 3-AMINO-4-METHYLBENZENESULFONAMIDE 2-amino-5-methylbenzenesulfonamide Pazopanib-d6 2H-Indazol-4-amine, 2,3-dimethyl-

1H-Indazol-6-amine, N-(2-chloro-4-pyrimidinyl)-3-methyl- 6-Nitroindazole Pazopanib Impurity 48

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2,4-DICHLOROPYRIMIDINE 2,6-DICHLOROPYRIMIDINE 2-4-DICHLOROPYRIMIDINE CRYSTALLINE AKOS 91058 2,4-dichloro-pyrimidin 2,4-Dichlorpyrimidin Pyrimidine,2,4-dichloro- 2,4DCPY 2,4-Dichloropyrimidine, 98+% Pyrimidine, 2,4-dichloro- (7CI,8CI,9CI) 2,4-Dichloropyrimidine, GC 97% 2,4-Dichloropyrimidine ,97% 2,4-Dichloropyrimidi 4-DichloropyriMidine 2,4-Dichloro-1,3-diazine 2,4-DichloropyriMidine, 97% 25GR 2-ChloropyriMidin-4-yl Chloride NSC 20212 NSC 37531 NSC 49119 2,4-Dichloropyrimidine, 97%, for synthesis 2,4-Dichloropyrimidine Pazopanib 2,4-dichloro pyrimidine( 2,4-DCP) Pazopanib Impurity 45 2,4-Dichloropyrimidine> 2,4-dichloropyrimidine hydrochloride 2-naphthalen-5-ylethanamine 2,4-dichloro pyrimdine 2,4-Dichloropyrimidine / Osimertinib intermediate DichloroPyrimidine-2,4 2,4-Dichioropyrimidine 3934-20-1 C4H2N2Cl2 C4H2Cl2N2 C4H2N2CI2 Building Blocks Heterocyclic Building Blocks Halogenated Heterocycles Pyrimidines HETERO CHLORIDE Halides Pyrazines, Pyrimidines & Pyridazines Aromatics Heterocycles Pyrazines, Pyrimidines & Pyridazines Heterocycle-Pyrimidine series PYRIMIDINE Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks PyrimidinesHeterocyclic Building Blocks Heterocyclic Compounds Building Blocks Aromatics Compounds Pyrimidines Pyrimidine Series Pyridines, Pyrimidines, Purines and Pteredines bc0001