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Madecassoside

Madecassoside Structure
Madecassoside structure
CAS No.
34540-22-2
Chemical Name:
Madecassoside
Synonyms
RederMic;MADECASSOIDE;MADECASSOSIDE;Asiaticoside A;MADECASSOSIDE(P);MADECASSOSIDE hplc;Madecassoside (8CI);MADECASSOSIDE WITH HPLC;Madecassoside (Asiaticoside A);Madecassoside, froM Centella asiatica
CBNumber:
CB6210654
Molecular Formula:
C48H78O20
Molecular Weight:
975.12
MDL Number:
MFCD03411893
MOL File:
34540-22-2.mol
Last updated:2024-04-23 19:22:53
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Madecassoside Properties

Melting point 220-223 °C
Boiling point 1043.6±65.0 °C(Predicted)
Density 1.47±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility H2O: soluble1mg/mL, clear, colorless
form powder
pka 12.50±0.70(Predicted)
color white to off-white
Stability Hygroscopic
InChIKey BNMGUJRJUUDLHW-CIZDPPTDSA-N
LogP -1.338 (est)
EWG's Food Scores 1
FDA UNII CQ2F5O6YIY

SAFETY

Risk and Safety Statements

Safety Statements  24/25
WGK Germany  3
RTECS  YU9555000
HS Code  29389090

Madecassoside price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M6949 Madecassoside from Centella asiatica ≥95% % (HPLC) 34540-22-2 10mg $185 2024-03-01 Buy
Sigma-Aldrich M6949 Madecassoside from Centella asiatica ≥95% % (HPLC) 34540-22-2 50mg $225.6 2024-03-01 Buy
Cayman Chemical 11855 Madecassoside ≥98% 34540-22-2 5mg $57 2024-03-01 Buy
Cayman Chemical 11855 Madecassoside ≥98% 34540-22-2 10mg $107 2024-03-01 Buy
Cayman Chemical 11855 Madecassoside ≥98% 34540-22-2 25mg $249 2024-03-01 Buy
Product number Packaging Price Buy
M6949 10mg $185 Buy
M6949 50mg $225.6 Buy
11855 5mg $57 Buy
11855 10mg $107 Buy
11855 25mg $249 Buy

Madecassoside Chemical Properties,Uses,Production

Description

Madecassoside is a triterpenoid saponin found in the tropical Asian plant C. asiatica. It has a wide range of reported anti-inflammatory, wound healing, and antioxidant activities and has been shown to suppress LPS-induced TNF-α production via inhibition of ERK, p38, and NF-κB activity.

Chemical Properties

Madecassoside is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide. The solubility of madecassoside in these solvents is approximately 5, 10, and 25 mg/ml, respectively.H2O : 33.33 mg/mL (34.18 mM)

Uses

Madecassoside is an antioxidant and anti-inflammatory agent. Used as a protective agent against cognitive impairment.

Definition

ChEBI: A triterpenoid saponin that is a trisaccharide derivative of madecassic acid. Isolated from Centella asiatica, it exhibits anti-inflammatory, antioxidant and antirheumatic activities.

Mechanism of action

Madecassoside can directly reduce the cytoskeletal protein actin expression of KFs and its mechanism of action is by inhibiting the activity of some (not all) of the several intracellular molecules that are responsible for abnormal keloid migration, including the significant, concentration‐dependent reduction of phosphorylated Akt, PI3K and p38 of KFs and the repression of actin‐depolymerization‐associated p‐cofilin/cofilin[1].

References

[1] Bandopadhyay s, et al. Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review. J. Cell. Mol. Med, 2023; 27: 593–608.

Madecassoside Preparation Products And Raw materials

Raw materials

Preparation Products

Madecassoside Suppliers

Global( 289)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Pioneer Biotech Co., Ltd .
+8613259417953 sales@pioneerbiotech.com China 3000 58
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12456 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5993 58
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907 qinhe02@xaltbio.com China 1000 58
Chongqing Zhihe Biopharmaceutical Co., Ltd. 		+86-18580541567 +86-17782035140 sales@zhswyy.com China 338 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 7845 58
BINBO BIOLOGICAL CO.,LTD 		+8618629063126 info@binbobiological.com China 290 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3620 58
Supplier Advantage
Shaanxi Pioneer Biotech Co., Ltd .
58
Hebei Mojin Biotechnology Co., Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Shaanxi Haibo Biotechnology Co., Ltd 		58
Chongqing Zhihe Biopharmaceutical Co., Ltd. 		58
Henan Fengda Chemical Co., Ltd 		58
BINBO BIOLOGICAL CO.,LTD 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Shanghai Zheyan Biotech Co., Ltd. 		58

View Lastest Price from Madecassoside manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Madecassoside pictures 2024-04-26 Madecassoside
34540-22-2
 US $0.00-0.00 / kg 0.10000000149011612kg ≥98% 20tons Chongqing Zhihe Biopharmaceutical Co., Ltd.
Madecassoside pictures 2024-04-23 Madecassoside
34540-22-2
 US $8.00-6.00 / kg 1kg 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
Madecassoside pictures 2024-04-22 Madecassoside
34540-22-2
 US $0.00 / kg 1kg 99.8% 1000 kg BINBO BIOLOGICAL CO.,LTD
  • Madecassoside pictures
  • Madecassoside
    34540-22-2
  • US $0.00-0.00 / kg
  • ≥98%
  • Chongqing Zhihe Biopharmaceutical Co., Ltd.
  • Madecassoside pictures
  • Madecassoside
    34540-22-2
  • US $8.00-6.00 / kg
  • 99%
  • Henan Fengda Chemical Co., Ltd
  • Madecassoside pictures
  • Madecassoside
    34540-22-2
  • US $0.00 / kg
  • 99.8%
  • BINBO BIOLOGICAL CO.,LTD

Madecassoside Spectrum

Madecassoside(34540-22-2)MS

34540-22-2(Madecassoside)Related Search:

Asiaticoside Centella asiatica extract Total Of Triterpenes PROPYLENE GLYCOL BUTYL ETHER METHYL 13-METHYLTETRADECANOATE
1,12-OCTADECANEDIOL isobutoxypropanol 6-O-BETA-D-GLUCOPYRANOSYL-D-GLUCOPYRANOSE isohexadecanoic acid 2-Ethyl-1,3-hexanediol
MONOLAURIN MONOCAPRYLIN Isopropyl-cyclohexanecarboxylic acid METHYL 15-HYDROXYPENTADECANOATE 15-HYDROXYPENTADECANOIC ACID
N-PENTADECANOIC ACID ETHYL ESTER ETHYL 2,2-DIETHYLBUTYRATE 1,3-DIISOPROPYLCYCLOHEXANE

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MADECASSOIDE MADECASSOSIDE O-6-Deoxy-alpha-L-mannopyranosyl-(1.4)-O-beta-D-glucopyranosyl-(1.6)-beta-D-glucopyranosyl (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oate O-6-deoxy-alpha-L-mannopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oate MADECASSOSIDE(P) MADECASSOSIDE hplc Asiaticoside A glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, (2α,3β,4α,6β)- Urs-12-en-28-oicacid, 2,3,6,23-tetrahydroxy-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D- 2α,3β,6β,23-Tetrahydroxyurs-12-en-28-oic acid 6-O-[4-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]-β-D-glucopyranosyl ester RederMic MADECASSOSIDE WITH HPLC Madecassoside, froM Centella asiatica Madecassoside, 98%, from Centella asiatica Madecassoside, 98%, from Centella asiatica (L.) Urb. Madecassoside (Asiaticoside A) Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, (2α,3β,4α,6β)- Madecassoside (8CI) (1S,2R,4aS,6aS,6bR,8R,8aR,9R,10R,11R,12aR,12bR,14bS)-(2S,3R,4S,5S,6R)-6-((((2R,3R,4R,5S,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl 8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate 34540-22-2 C48H78O20 Inhibitors The group of Asiaticoside chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Saponins