5,6,7-Trimethoxy-2-methylisoquinolin-1(2H)-one

5,6,7-Trimethoxy-2-methylisoquinolin-1(2H)-one structure

CAS No.: 23434-97-1

Chemical Name:: 5,6,7-Trimethoxy-2-methylisoquinolin-1(2H)-one

Synonyms: Thalactamine;5,6,7-Trimethoxy-2-methylisoquinolin-1(2H)-one;1(2H)-Isoquinolinone, 5,6,7-trimethoxy-2-methyl-

CBNumber:: CB62171711

Molecular Formula:: C13H15NO4

Molecular Weight:: 249.26

MDL Number:

MOL File:: 23434-97-1.mol

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5,6,7-Trimethoxy-2-methylisoquinolin-1(2H)-one Properties

Melting point	112-114 °C
Boiling point	441.3±45.0 °C(Predicted)
Density	1.191±0.06 g/cm3(Predicted)
pka	-2.22±0.70(Predicted)

5,6,7-Trimethoxy-2-methylisoquinolin-1(2H)-one Chemical Properties,Uses,Production

Description

The aerial portions of Thalictrum minus yield this alkaloid which has been shown to possess the structure of 1: 2-dihydro-5: 6: 7-trimethoxy-2-methyl-loxoisoquinoline. It gives an ultraviolet spectrum in EtOH with absorption maxima at 247, 270, 281, 293 and 332 nm. The base is stable to both acid and alkaline hydrolysis and hydrogenation with LiAlH4,NaBH4 or PtO2 up to 100°C but catalytic hydrogenation at 80°C and 80 atmospheres furnishes the dihydro derivative, m.p. 104-6°C.

References

Mollov, Dutschewska, Tetrahedron Lett., 1951 (1969)

5,6,7-Trimethoxy-2-methylisoquinolin-1(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

5,6,7-Trimethoxy-2-methylisoquinolin-1(2H)-one Thalactamine 1(2H)-Isoquinolinone, 5,6,7-trimethoxy-2-methyl- 23434-97-1