Isotubulosine
- CAS No.
- 5610-39-9
- Chemical Name:
- Isotubulosine
- Synonyms
- Isotubulosine;1'-Isotubulosine;(1'S)-10,11-Dimethoxytubulosan-8'-ol;1H-Pyrido[3,4-b]indol-6-ol, 1-[[(2S,3R,11bS)-3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizin-2-yl]methyl]-2,3,4,9-tetrahydro-, (1S)-
- CBNumber:
- CB62228936
- Molecular Formula:
- C29H37N3O3
- Molecular Weight:
- 475.62
- MDL Number:
- MOL File:
- 5610-39-9.mol
Isotubulosine Chemical Properties,Uses,Production
Description
A complex alkaloid occurring in Alangium lamarckii Thw., the base yields colourless crystals from EtOH and is laevorotatory with [α]25D - 84° (c 1.0, pyridine). The ultraviolet spectrum has been fully determined. In MeOH it shows a single broad absorption maximum at 279 mJl. In 0.1 N/HC1 there is a very small hypsochromic shift to 277 mJl while in 0.1 N/NaOH, there are two absorp_x0002_tion maxima at 279 and 319 mμ. Two methoxyl groups, two imino groups and one hydroxyl group are present. The latter furnishes the O-methy1 ether, m.p. 163°C;[α]20D - 18.8° (MeOH). The above structure has been confirmed by synthesis.
References
Popelak, Haack, Springler., Tetrahedron Lett., 5077 (1966)
Synthesis:
Openshaw, Whittaker., Chem. Commun., 131 (1966)
Isotubulosine Preparation Products And Raw materials
Raw materials
Preparation Products
(1'S)-10,11-Dimethoxytubulosan-8'-ol
1'-Isotubulosine
Isotubulosine
1H-Pyrido[3,4-b]indol-6-ol, 1-[[(2S,3R,11bS)-3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizin-2-yl]methyl]-2,3,4,9-tetrahydro-, (1S)-
5610-39-9