1,3-Dithiane
- CAS No.
- 505-23-7
- Chemical Name:
- 1,3-Dithiane
- Synonyms
- 1,3-Dithian;M-DITHIANE;1,3-DITHIANE;1,3-Dithane;Dithiane-1,3;META-DITHIANE;1,3-Dithiane>1,3-Dithiane,97%;1,3-Dithiane,99%;1,3-Dithiane,98%
- CBNumber:
- CB6223805
- Molecular Formula:
- C4H8S2
- Molecular Weight:
- 120.24
- MDL Number:
- MFCD00006654
- MOL File:
- 505-23-7.mol
- MSDS File:
- SDS
| Melting point | 52-54 °C (lit.) |
|---|---|
| Boiling point | 207-208°C |
| Density | 1.062 (estimate) |
| refractive index | 1.5981 (estimate) |
| Flash point | 195 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| form | Crystals, Needles or Powder |
| pka | 31(at 25℃) |
| color | White to pale beige |
| Odor | at 0.01 % in propylene glycol. alliaceous roasted |
| Odor Type | alliaceous |
| Water Solubility | Soluble in benzene, ether, chloroform and terahydrofuran. Slightly soluble in water. |
| Sensitive | Hygroscopic |
| BRN | 102534 |
| InChIKey | WQADWIOXOXRPLN-UHFFFAOYSA-N |
| LogP | 1.729 (est) |
| CAS DataBase Reference | 505-23-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 63527N060G |
| NIST Chemistry Reference | 1,3-Dithiane(505-23-7) |
1,3-Dithiane price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 157872 | 1,3-Dithiane 97% | 505-23-7 | 5g | $54.6 | 2024-03-01 | Buy |
| TCI Chemical | D0119 | 1,3-Dithiane >97.0%(GC) | 505-23-7 | 5g | $69 | 2024-03-01 | Buy |
| TCI Chemical | D0119 | 1,3-Dithiane >97.0%(GC) | 505-23-7 | 25g | $214 | 2024-03-01 | Buy |
| Alfa Aesar | A10505 | 1,3-Dithiane, 98% | 505-23-7 | 5g | $47.65 | 2024-03-01 | Buy |
| Alfa Aesar | A10505 | 1,3-Dithiane, 98% | 505-23-7 | 25g | $160.65 | 2024-03-01 | Buy |
1,3-Dithiane Chemical Properties,Uses,Production
Chemical Properties
white to pale beige crystals, needles or powder
Uses
1,3-Dithiane is used in umpolung reactions such as the Corey-Seebach reaction. It acts as a reagent for the deoxygenation of sulfoxides to their corresponding sulfides. Further, it is used as a protecting group for carbonyl compounds used in organic synthesis. It serves as a useful labeled synthon. In addition to this, it is used in the preparation of 2-ethyl-[1,3]dithiane.
Definition
ChEBI: 1,3-dithiane is a dithiane.
Reactions
1,3-dithiane has 2 weakly acidic protons that can be removed and alkylation of the carbon is possible. Once alkylated, the 1,3-dithiane becomes a “protected” carbonyl as it can be hydrolyzed to the corresponding carbonyl structure. Alternatively, the 1,3-dithiane moiety may also be introduced by thioacetalisation of a carbonyl group, either using acid or Lewis acid catalysis, 12 or of a 1,1-dihalide (using transition metal catalysis).
Synthesis Reference(s)
Tetrahedron Letters, 29, p. 4477, 1988 DOI: 10.1016/S0040-4039(00)80527-4
General Description
1,3-Dithiane, a protected formaldehyde anion equivalent, serves as useful labeled synthon.
Purification Methods
Crystallise the 1,3-dithiane from 1.5 times its weight of MeOH at 0o, and sublime it at 40-50o/0.1mm. [Groel & Seebach Synthesis 357 1977, Beilstein 19/1 V 13.]
1,3-Dithiane Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21149 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
View Lastest Price from 1,3-Dithiane manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 1,3-Dithiane
505-23-7
|
US $2.00 / kg | 1kg | 99% | ask | Career Henan Chemical Co |
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- 1,3-Dithiane
505-23-7
- US $2.00 / kg
- 99%
- Career Henan Chemical Co
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