N'-NITROSONORNICOTINE
- CAS No.
- 16543-55-8
- Chemical Name:
- N'-NITROSONORNICOTINE
- Synonyms
- NNN;(2S)-N’nitrosonornicotine;N-NITROSONORNICOTINE;N'-NITROSONORNICOTINE;1’-nitrosonornicotine;N'-NITROSONORNICOTINE;-Nitrosonornicotine-d4;N-nitroso nicotine (NNN);(S)-N’-Nitrosonornicotine
- CBNumber:
- CB6227878
- Molecular Formula:
- C9H11N3O
- Molecular Weight:
- 177.2
- MDL Number:
- MFCD00870187
- MOL File:
- 16543-55-8.mol
| Melting point | 47.1°C |
|---|---|
| Boiling point | 309.13°C (rough estimate) |
| Density | 1.1669 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | Hygroscopic, Refrigerator, Under Inert Atmosphere |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 5.16±0.12(Predicted) |
| color | Off-White to Pale Beige |
| Stability | Stable, but air and light sensitive. Incompatible with oxidizing agents. |
| FDA UNII | X656TZ86DX |
| IARC | 1 (Vol. Sup 7, 89, 100E) 2012 |
| Proposition 65 List | N-Nitrosonornicotine |
| EPA Substance Registry System | N-Nitrosonornicotine (16543-55-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
| Hazard Codes | Xn |
| Risk Statements | 36/37/38-40 |
| Safety Statements | 26-36 |
| RIDADR | 2810 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 intraperitoneal in mouse: 1gm/kg |
N'-NITROSONORNICOTINE price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N-075 | (±)-N′-Nitrosonornicotine (NNN) solution 1.0?mg/mLinmethanol,ampuleof1?mL,certifiedreferencematerial,Cerilliant? | 16543-55-8 | 1mL | $131 | 2022-05-15 | Buy |
| TRC | N535001 | (2S)-N’-Nitrosonornicotine | 16543-55-8 | 10mg | $185 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | D34102 | N?-Nitrosonornicotine-d4 | 16543-55-8 | 5mg | $1250 | 2021-12-16 | Buy |
N'-NITROSONORNICOTINE Chemical Properties,Uses,Production
Description
A nicotine alkaloid, this base has been detected in some Japanese cigarette tobaccos and also in Kirsu tobacco where it occurs in the fresh leaves that have been dried without fermentation. From these two sources it has been isolated at 1.1 and 1. 8 ppm levels respectively
Chemical Properties
white crystals
Uses
A tobacco alkaloid as risk factor of human cancer.
General Description
White crystalline flakes or yellow oil that solidifies on standing in the cold.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
A nitrated amine, nicotine derivative. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition it may emit toxic and hazardous fumes of NOx and COx.
Fire Hazard
Flash point data for N'-NITROSONORNICOTINE are not available; however, N'-NITROSONORNICOTINE is probably combustible.
Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Low toxicity by intraperitoneal route. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.
Carcinogenicity
N-Nitrosonornicotine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
References
Bharadwaj et al., Gann., 66, 585 (1975)
N'-NITROSONORNICOTINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Shanxi Tihondan Pharmaceutical Technology Co., Ltd | +8618235132063 | sales@tihondan.com | China | 3701 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| guoyungurui | 18162595016 | 3287908757@qq.com | China | 10015 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9664 | 60 |
| ChemStrong Scientific Co.,Ltd | 0755-66853366 13670046396 | sales@chem-strong.com | China | 17982 | 56 |
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