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Coluracetam

CAS No.
135463-81-9
Chemical Name:
Coluracetam
Synonyms
BCI-540;COLURACETAM;Colurac tam;MKC-231;BCI-540;Coluracetam, >=99%;Coluracetam, MKC-231;COLURACETAM USP/EP/BP;top quality Coluracetam;MKC-231; MKC231; MKC 231;CAS135463-81-9 COLURACETAM
CBNumber:
CB62446491
Molecular Formula:
C19H23N3O3
Molecular Weight:
341.4
MDL Number:
MFCD00901416
MOL File:
135463-81-9.mol
Last updated:2024-03-28 14:27:36

Coluracetam Properties

Boiling point 634.1±55.0 °C(Predicted)
Density 1.291±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMF: 1 mg/ml; DMSO: 2 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol
form A crystalline solid
pka 12.01±0.20(Predicted)
InChI InChI=1S/C19H23N3O3/c1-11-12(2)25-19-17(11)18(13-6-3-4-7-14(13)20-19)21-15(23)10-22-9-5-8-16(22)24/h3-10H2,1-2H3,(H,20,21,23)
InChIKey PSPGQHXMUKWNDI-UHFFFAOYSA-N
SMILES N1(CC(NC2C3=C(N=C4OC(C)=C(C)C4=2)CCCC3)=O)CCCC1=O
FDA UNII V6FL6O5GR7

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS09
Signal word  Warning
Hazard statements  H411
Precautionary statements  P501-P273-P391
NFPA 704
0
2 0

Coluracetam price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-2196 Coluracetam 99.87% 135463-81-9 10mg $60 2021-12-16 Buy
ApexBio Technology B1158 Coluracetam 135463-81-9 10mg $79 2021-12-16 Buy
ChemScene CS-2196 Coluracetam 99.87% 135463-81-9 50mg $80 2021-12-16 Buy
ChemScene CS-2196 Coluracetam 99.87% 135463-81-9 5mg $50 2021-12-16 Buy
ChemScene CS-2196 Coluracetam 99.87% 135463-81-9 100mg $90 2021-12-16 Buy
Product number Packaging Price Buy
CS-2196 10mg $60 Buy
B1158 10mg $79 Buy
CS-2196 50mg $80 Buy
CS-2196 5mg $50 Buy
CS-2196 100mg $90 Buy

Coluracetam Chemical Properties,Uses,Production

Uses

Copiracetam can be used as a nootropic drug to treat memory and intellectual impairments caused by senile dementia, mild to moderate vascular dementia, trauma and other diseases, and to promote children's intellectual development; it also has antidepressant effects.

Pharmacology

Copiracetam has the ability to improve cognition by participating in the HACU process, increasing the rate-limiting step of synaptic intake of choline to synthesize the neurotransmitter acetylcholine, and increasing the activity of cholinergic neurons.

in vitro

Coluracetam (10(-10)-10(-6) moll), also known as MKC-231, significantly increased high affinity choline uptake (HACU) when it was incubated with the hippocampal synaptosomes of ethylcholine mustard aziridinium ion (AF64A) treated rats, but not of normal rats. MKC-231 did not affect the AChE activity, [3H]- quinuclidinyl benzilate binding, and [3H]-pirenzepine binding.

in vivo

Oral administration of MKC-231 (Coluracetam; 1-10 mg/kg) significantly improved the learning deficits in the Morris' water maze of AF64A-treated rats, but it did not produce any significant side effects, like tremor, salivation or hypothermia, which were observed in rats treated with high doses of tacrine [1]. In acute behavioral experiments, MKC-231 and THA had no significant effect on AF64A-induced memory deficits at any doses tested (0.3, 1.0 and 3.0 mg/kg), whereas Dup 996, at a dose of 1.0 mg/kg, significantly improved memory deficits. In chronic experiments, MKC-231 improved memory deficit at all doses tested (0.3, 1.0, or 3.0 mg/kg p.o., once daily for 11 days) and Dup 996 did so only at a dose of 3.0 mg/kg, whereas THA did not improve memory deficit at any doses tested.

Coluracetam Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 206)Suppliers
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Hubei Langyou International Trading Co., Ltd
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View Lastest Price from Coluracetam manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
COLURACETAM pictures 2024-03-29 COLURACETAM
135463-81-9
US $108.00-104.00 / Grams 50Grams 99.99% 100Tons Hebei Dangtong Import and export Co LTD
Coluracetam pictures 2024-03-28 Coluracetam
135463-81-9
US $50.00 / kg 1kg 99.8% 20 tons Hubei Chuyan Biopharmaceutical Co., Ltd
Coluracetam pictures 2024-03-27 Coluracetam
135463-81-9
US $60.00-150.00 / KG 1KG 99% 20 tons Hubei Chuyan Biopharmaceutical Co., Ltd
  • COLURACETAM pictures
  • COLURACETAM
    135463-81-9
  • US $108.00-104.00 / Grams
  • 99.99%
  • Hebei Dangtong Import and export Co LTD
  • Coluracetam pictures
  • Coluracetam
    135463-81-9
  • US $50.00 / kg
  • 99.8%
  • Hubei Chuyan Biopharmaceutical Co., Ltd
  • Coluracetam pictures
  • Coluracetam
    135463-81-9
  • US $60.00-150.00 / KG
  • 99%
  • Hubei Chuyan Biopharmaceutical Co., Ltd

Coluracetam Spectrum

COLURACETAM N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide 1-Pyrrolidineacetamide,2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethylfuro[2,3-b]quinolin-4-yl)- Coluracetam, MKC-231 1-[N-(2,3-DiMethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)carbaMoylMethyl]pyrrolidin-2-one BCI-540 Coluracetam, >=99% 2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethyl-furo[2,3-b]quinolin-4-yl)-1-pyrrolidineacetamide coluracetam cas: 135463-81-9 MKC-231;BCI-540 MKC-231; MKC231; MKC 231 top quality Coluracetam COLURACETAM USP/EP/BP CAS135463-81-9 COLURACETAM Furo(2,3-b)quinoline-1-pyrrolidineacetamide Deriv COLURACETAM MKC-231 BCI-540 Colurac tam 135463-81-9 Brain health drug Nootropic pharmaceutical intermediate or medicine grade pharmaceutical