ChemicalBook >> CAS DataBase List >>1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
- CAS No.
- 3543-73-5
- Chemical Name:
- 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
- Synonyms
- ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate;5-AMino-1-Methyl-;Bendamustine Intermediate;1-Methyl-5-amino-1H-benzimidazole-2;BendaMustine hydrochloride interMediate;endamustine Dideschloroethyl Ethyl Ester;BendaMustine Dideschloroethyl Ethyl Ester;Bendamustine hydrochloride Intermediates 2;4-(5-amino-1-methyl-1H-benzimidazol-2-yl)butanoate;Ethyl 5-amino-1-methyl-1H-benzimidazole-2-butanoate
- CBNumber:
- CB62485092
- Molecular Formula:
- C14H19N3O2
- Molecular Weight:
- 261.32
- MDL Number:
- MFCD09840909
- MOL File:
- 3543-73-5.mol
Last updated:2024-03-25 09:59:57
| Melting point | 130-135°C |
|---|---|
| Boiling point | 471.6±25.0 °C(Predicted) |
| Density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| pka | 6.73±0.10(Predicted) |
| color | Off-White to Pale Beige |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P305+P351+P338 |
| HS Code | 2933998090 |
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M285645 | 1-Methyl-5-amino-1H-benzimidazole-2-butanoicAcidEthylEster | 3543-73-5 | 5mg | $60 | 2021-12-16 | Buy |
| Matrix Scientific | 102756 | Ethyl 4-(5-amino-1-methyl-1H-1,3-benzimidazol-2-yl)butanoate >97% | 3543-73-5 | 1g | $92 | 2021-12-16 | Buy |
| AK Scientific | J97551 | 1-Methyl-5-amino-1H-benzimidazole-2-butanoicacidethylester | 3543-73-5 | 1g | $45 | 2021-12-16 | Buy |
| Matrix Scientific | 102756 | Ethyl 4-(5-amino-1-methyl-1H-1,3-benzimidazol-2-yl)butanoate >97% | 3543-73-5 | 5g | $342 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H58-1-CV | Ethyl 4-(5-amino-1-methyl-1H-1,3-benzimidazol-2-yl)butanoate | 3543-73-5 | 1g | $436 | 2021-12-16 | Buy |
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Chemical Properties,Uses,Production
Chemical Properties
Brown Solid
Uses
1-Methyl-5-amino-1H-benzimidazole-2-butanoic Acid Ethyl Ester is a Bendamustine impurity.
Synthesis
In the hydrogenation reaction kettle by adding 50 g 1 - methyl -5 - nitro - 1H - benzimidazole -2 - butyric acid ethyl ester, 2.5 g 5% palladium/carbon, 1.3 L methanol, 475 ml ethyl acetate, hydrogen pressure control in the 0.1 - 0.2 mpa, reaction solution is 25 °C reaction 15 hours, TLC monitoring endpoint of the reaction to the reaction is complete. The fluid in a 35 °C decompression filter collects the filtrate; the filtrate is concentrated under reduced pressure to dry after adding 75 ml ethyl acetate, 70 °C stirring for 0.5 hours. After that, the mixture was to 5 °C stirring for 0.5 hours, for 5 °C standing crystallization for 2 hours, filtering, washing the filter cake with acetic acid ethyl ester, filtration cake at 50 °C decompression drying for 5 hours to afford 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester 35 g, yield 77.8%.
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 203)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Lianyungang happen teng technology co., LTD | 15950718863 | wang666xt@163.com | CHINA | 295 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
View Lastest Price from 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
3543-73-5
|
US $1.00 / kg | 1kg | 99% | Customized | Career Henan Chemical Co |
-
- 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
3543-73-5
- US $1.00 / kg
- 99%
- Career Henan Chemical Co
3543-73-5(1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester)Related Search:
5-AMINO-1-METHYL-1H-BENZIMIDAZOLE-2-BUTANOIC ACID ETHYL ESTER
Ethyl-4-(5-aMino-1-Methy-1H-benzo[d] iMidazol-2-yl)butanoate
1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester
4-(5-Amino-1-methyl-1H-benzoimidazol-2-yl)-butyric acidethylester
5-amino-1-methyl-2-Benzimidazolebutyric acid ethyl ester
5-AMino-1-Methyl-
4-[5-AMino-1-MethylbenziMidazol-2-yl]butanoic acid ethyl ester
1-Methyl-5-aMino-1H-benziMidazole-2-butanoic acid ethyl este
BendaMustine hydrochloride interMediate
4-(5-aMino-1-Methyl-1H-benzoiMidazol-2-yl)-butyric acid ethyl esterCAS
BendaMustine Dideschloroethyl Ethyl Ester
ethyl 4-(5-aMino-1-Methyl-1H-1,3-benzodiazol-2-yl)butanoate
ethyl 4-(5-amino-1-methylbenzimidazol-2-yl)butanoate
Bendamustine Intermediate
Ethyl 4-(5-amino-1-methyl-1H-1,3-benzimidazol-2-yl)butanoate
Bendamustine hydrochloride Intermediates 2
5-(5-amino-1-methyl-2-benzimidazolyl)-1-methoxy-2-pentanone
4-(5-amino-1-methyl-1H-benzimidazol-2-yl)butanoate
1-Methyl-5-amino-1H-benzimidazole-2
endamustine Dideschloroethyl Ethyl Ester
1H-Benzimidazole-2-butanoic acid, 5-amino-1-methyl-, ethyl ester
Ethyl4-(5-amino-1-methyl-1Hbenzo[d]imidazole
-2-yl)butanoate
ETHYL 4-(5-AMINO-1-METHYL-1HBENZIMIDAZOL-2-YL) BUTANOATE
ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate
Bendamustine Hydrochloride Intermediate 3543-73-5 API Manufacturer
Ethyl 5-amino-1-methyl-1H-benzimidazole-2-butanoate
3543-73-5
Aromatics
Heterocycles
Intermediates