TC-SP 14
- CAS No.
- 1257093-40-5
- Chemical Name:
- TC-SP 14
- Synonyms
- TC-SP 14;1-[[3-Fluoro-4-[5-[(2-fluorophenyl)Methyl]-2-benzothiazolyl]phenyl]Methyl]-3-azetidinecarboxylic Acid;3-Azetidinecarboxylic acid, 1-[[3-fluoro-4-[5-[(2-fluorophenyl)methyl]-2-benzothiazolyl]phenyl]methyl]-
- CBNumber:
- CB62603007
- Molecular Formula:
- C25H20F2N2O2S
- Molecular Weight:
- 450.5
- MDL Number:
- MFCD22683814
- MOL File:
- 1257093-40-5.mol
TC-SP 14 price More Price(6)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Tocris | 4363 | TC-SP14 ≥98%(HPLC) | 1257093-40-5 | 10 | $178 | 2021-12-16 | Buy |
Tocris | 4363 | TC-SP14 ≥98%(HPLC) | 1257093-40-5 | 50 | $746 | 2021-12-16 | Buy |
TRC | F588420 | 1-[[3-Fluoro-4-[5-[(2-fluorophenyl)methyl]-2-benzothiazolyl]phenyl]methyl]-3-azetidinecarboxylicAcid | 1257093-40-5 | 50mg | $760 | 2021-12-16 | Buy |
Usbiological | 256861 | TC-SP 14 | 1257093-40-5 | 10mg | $480 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | INB0001549 | TC-SP-14 98.00% | 1257093-40-5 | 5MG | $496.67 | 2021-12-16 | Buy |
TC-SP 14 Chemical Properties,Uses,Production
Uses
1-[[3-Fluoro-4-[5-[(2-fluorophenyl)methyl]-2-benzothiazolyl]phenyl]methyl]-3-azetidinecarboxylic Acid is a potent Sphingosine-1-Phosphate Receptor 1 (S1P1) agonist with minimal activity at S1P3. It has been shown to attenuate DTH response to antigen challenge while significantly reducing blood lymphocyte counts.
Biological Activity
ec50: 0.042 μm for hs1p1tc-sp 14 is an agonist of sphingosine-1-phosphate receptor 1 (s1p1).studies have revealed that the lysophospholipid sphingosine-1-phosphate (s1p1) is a pleiotropic modulator of diverse cellular processes. such effects are reported to be mediated by the interactions of s1p with a set of paralogous g proteincoupled receptors, which are widely expressed in the immune, central nervous and cardiovascular systems.
in vitro
as a small lipophilic substituent proved equally effective to a larger substituent in reducing s1p3 activity, tc-sp 14 was screened. tc-sp 14 was found to be a potent s1p1 agonist (ec50 = 0.042 μm) with reduced activity for s1p3 (ec50 = 3.47 μm) [1].
in vivo
in lewis rats, tc-sp 14 produced a dose-dependent reduction in circulating blood lymphocytes, which was consistent with s1p1 agonism. moreover, statistical significance was shown at a dose of 0.3 mg/kg, and the dose fo 3.0 mg/kg led to near maximal lymphopenia. tc-sp 14 was subsequently investigated in a dth antigen challenge model. results showed a statistically significant reduction in ear swelling at doses of 0.3 mg/kg and higher. in addition, reduced ear swelling was found to closely track circulating lymphocyte counts [1].
References
[1] lanman ba,cee vj,cheruku sr et al. discovery of a potent, s1p3-sparing benzothiazole agonist of sphingosine-1-phosphate receptor 1 (s1p1). acs med chem lett.2010 nov 9;2(2):102-6.
TC-SP 14 Preparation Products And Raw materials
Raw materials
Preparation Products
TC-SP 14 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55934 | 58 |
BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
Shanghai YuZn Pharm. Technology Co.,Ltd. | 15921286451; 15921286451 | 2010681527@qq.com | China | 5067 | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4164 | 58 |