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CHIR-090

CHIR-090 structure

CAS No.: 728865-23-4

Chemical Name:: CHIR-090

Synonyms: CS-2285;CHIR-090;CHIR-090 (CHIR 090;N-((2S,3R)-3-Hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl)-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamide;N-[(1S,2R)-2-Hydroxy-1-[(hydroxyamino)carbonyl]propyl]-4-[[4-(4-morpholinylmethyl)phenyl]ethynyl]benzamide;N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[2-[4-(morpholin-4-ylmethyl)phenyl]ethynyl]benzamide;Benzamide, N-[(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl]-4-[2-[4-(4-morpholinylmethyl)phenyl]ethynyl]-;N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[2-[4-(morphChemicalbookolin-4-ylmethyl)phenyl]ethynyl]benzamide

CBNumber:: CB62645119

Molecular Formula:: C24H27N3O5

Molecular Weight:: 437.49

MDL Number:: MFCD22665727

MOL File:: 728865-23-4.mol

MSDS File:: SDS

Last updated:2023-06-08 09:03:09

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CHIR-090 Properties

Density	1.33±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	≥21.85 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form	solid
pka	9.11±0.40(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS08

Signal word

Danger

Hazard statements

H315-H318-H334-H317-H341-H361-H370-H413

Precautionary statements

P201-P202-P260-P264-P270-P272-P273-P280-P284-P302+P352-P304+P341-P305+P351+P338-P310-P308+P313-P321-P362+P364-P333+P313-P342+P311-P363-P405-P501

NFPA 704

	0
3		0

CHIR-090 price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML3092	CHIR-090 ≥98% (HPLC)	728865-23-4	5MG	$146	2024-03-01	Buy
Sigma-Aldrich	SML3092	CHIR-090 ≥98% (HPLC)	728865-23-4	25MG	$468	2024-03-01	Buy
Cayman Chemical	22256	CHIR090 ≥98%	728865-23-4	1mg	$57	2024-03-01	Buy
Cayman Chemical	22256	CHIR090 ≥98%	728865-23-4	5mg	$166	2024-03-01	Buy
Cayman Chemical	22256	CHIR090 ≥98%	728865-23-4	10mg	$275	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML3092	5MG	$146	Buy
SML3092	25MG	$468	Buy
22256	1mg	$57	Buy
22256	5mg	$166	Buy
22256	10mg	$275	Buy

CHIR-090 Chemical Properties,Uses,Production

Description

CHIR-090 is the first reported compound that in fact kills both E. coli and Pseudomonas aeruginosa in bacterial disk diffusion assays (Liang et al. 2011). Nonetheless, CHIR-090 was about 600-fold less effective against LpxC orthologs from the Rhizobiaceae family than against E. coli LpxC. In this way, studies have shown that the removal of morpholine ring, based on a chemical scaffold of reduced radius, was able to increase affinity by 20-fold for LpxC enzymes from the Rhizobiaceae family of bacteria and enhance the antibiotic activity against E. coli and P. aeruginosa by 2–4 fold over CHIR-090.

Definition

ChEBI: CHIR-090 is an L-threonine derivative obtained by formal condensation of the carboxy group of 4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzoic acid with the amino group of N-hydroxy-L-threoninamide. It has a role as an antimicrobial agent, a lipopolysaccharide biosynthesis inhibitor and an EC 3.5.1.108 (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor. It is an acetylenic compound, a member of morpholines, a member of benzamides, a L-threonine derivative and a hydroxamic acid.

target

LpxC

CHIR-090 synthesis

Synthesis of CHIR-090 from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

CHIR-090 Preparation Products And Raw materials

Raw materials

methyl 4-(2-(trimethylsilyl)ethynyl)benzoate 4-ETHYNYLBENZOIC ACID SODIUM SALT 4-IODOBENZALDEHYDE Methyl 4-iodobenzoate Morpholine

Preparation Products

CHIR-090 Suppliers

Global( 84)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
PT CHEM GROUP LIMITED	+86-85511178 +86-85511178	peter68@ptchemgroup.com	China	35453	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49999	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
career henan chemical co	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58
PT CHEM GROUP LIMITED	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
GIHI CHEMICALS CO.,LIMITED	58

View Lastest Price from CHIR-090 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-24	N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[2-[4-(morpholin-4-ylmethyl)phenyl]ethynyl]benzamide 728865-23-4	US $1.00 / KG	1KG	Min98% HPLC	g/kg/ton	Career Henan Chemical Co

N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[2-[4-(morpholin-4-ylmethyl)phenyl]ethynyl]benzamide
728865-23-4
US $1.00 / KG
Min98% HPLC
Career Henan Chemical Co

CHIR-090 Spectrum

CHIR-090(728865-23-4)¹HNMR

728865-23-4(CHIR-090)Related Search:

6,8-DIFLUORO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-ONE N-Hydroxy-5-Methyl-1H-Indole-3-carboxiMidaMide 5-(Bromomethyl)-2-methylthiazole 3-Azetidinone, 1-[(4-methylphenyl)sulfonyl]- L-tert-leucinaMide hydrochloride

Thiazole-2,4-diaMine hydrochloride Bicyclo[3.1.0]hexan-3-amine hydrochloride 4-[[4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone

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CHIR-090 N-[(1S,2R)-2-Hydroxy-1-[(hydroxyamino)carbonyl]propyl]-4-[[4-(4-morpholinylmethyl)phenyl]ethynyl]benzamide N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[2-[4-(morpholin-4-ylmethyl)phenyl]ethynyl]benzamide CHIR-090 (CHIR 090 CS-2285 Benzamide, N-[(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl]-4-[2-[4-(4-morpholinylmethyl)phenyl]ethynyl]- N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-[2-[4-(morphChemicalbookolin-4-ylmethyl)phenyl]ethynyl]benzamide N-((2S,3R)-3-Hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl)-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamide 728865-23-4