ChemicalBook >> CAS DataBase List >>1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid structure

CAS No.: 1335210-23-5

Chemical Name:: 1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

Synonyms: BNKY001-DL01;Dulotegravir Me-N-4;Bictegravir Intermediate;Dolutegravir Impurity 58;Dolutegravir Intermediates3;Bictegravir Related Compound 1;1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxy;1-(2,2-Dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-2,5-pyrid...;1-(2,2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid;Methyl 5-acetyl-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate

CBNumber:: CB62714273

Molecular Formula:: C13H17NO8

Molecular Weight:: 315.28

MDL Number:: MFCD28978322

MOL File:: 1335210-23-5.mol

MSDS File:: SDS

Last updated:2024-03-18 11:53:02

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1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Properties

Boiling point	474.1±45.0 °C(Predicted)
Density	1.36±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform, DMSO (Slightly), Methanol (Slightly)
pka	5.56±0.40(Predicted)
form	Solid
color	White to Light Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	D528812	Dolutegravirintermediate-1	1335210-23-5	10mg	$45	2021-12-16	Buy
AK Scientific	3307DL	1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylicacid	1335210-23-5	1g	$68	2021-12-16	Buy
Crysdot	CD11292488	1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylicacid 97%	1335210-23-5	5g	$149	2021-12-16	Buy
Chemenu	CM172459	1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylicacid 97%	1335210-23-5	5g	$153	2021-12-16	Buy
Chemenu	CM172459	1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylicacid 97%	1335210-23-5	10g	$224	2021-12-16	Buy

Product number	Packaging	Price	Buy
D528812	10mg	$45	Buy
3307DL	1g	$68	Buy
CD11292488	5g	$149	Buy
CM172459	5g	$153	Buy
CM172459	10g	$224	Buy

1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Chemical Properties,Uses,Production

Uses

Dolutegravir intermediate-1 (1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid) is used as an intermediate in the synthesis of GSK1265744 (I), a potent HIV integrase inhibitor.

Synthesis

N, N-Dimethylformamide dimethyl acetal was added to methyl 4-methoxy-3-oxobutanoate, and the mixture was kept for 2 h at 25-30°C. The resulting methyl2-(dimethylaminomethylidene)-4-methoxy-3-oxobutanoate was dissolved in methanol, 2-amino acetaldehyde dimethyl acetal was added, and the mixture was stirred at20-30°C for 2 h. The solvent was removed under reduced pressure, the residue was diluted with methanol, and dimethyl oxalate was added at 25-30°C. The mixture was cooled to 0-5°C, 30 wt % sodium methoxide in methanol was slowly added, and the mixture was slowly heated to 40°C, stirred for 14 h at that temperature, and concentrated under reduced pressure. The residue was diluted with dichloromethane and poured into cold (0-5°C)2 N aqueous HCl. The organic phase was separated, the aqueous layer was extracted with dichloromethane (2× ), and the combined organic layers were washed with demineralized water and concentrated under reduced pressure at 40-45 °C to obtain intermediate. The product was dissolved in methanol, the solution was cooled to 0-5°C, and lithium hydroxide monohydrate was added. The mixture was stirred at 0-5°C for 3 h, quenched with 2 N aqueous HCl, and extracted with ethyl acetate (3×). Finally, the product 1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid can be obtained through further purification.

1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid synthesis

Synthesis of 1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid from Dimethyl oxalate and methyl 2-(((2,2-dimethoxyethyl)amino)methylene)-4-methoxy-3-oxobutanoate

1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Preparation Products And Raw materials

Raw materials

methyl 2-(((2,2-dimethoxyethyl)amino)methylene)-4-methoxy-3-oxobutanoate Dimethyl oxalate

Preparation Products

(2R,5S,13aR)-8-methoxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxylic acid (4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid

1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Suppliers

Global( 195)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BIONNA MEDICINE CO.,LTD	01056380788-8515; +8618518759099	790226113@qq.com	China	52	58
Shanghai Joiny Pharmaceutical Co.,LTD	+8613681955282	gyd@joiny-pharma.com	China	228	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
Lianyungang happen teng technology co., LTD	15950718863	wang666xt@163.com	CHINA	295	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Zhejiang ZETian Fine Chemicals Co. LTD	18957127338	stella@zetchem.com	China	2141	58

Supplier	Advantage
BIONNA MEDICINE CO.,LTD	58
Shanghai Joiny Pharmaceutical Co.,LTD	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
Lianyungang happen teng technology co., LTD	58
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58

View Lastest Price from 1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-10	1-(2,2-Dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-2,5-pyridinedicarboxylic acid 2-methyl ester 1335210-23-5	US $0.00 / kg	1kg	98%	1000kg	Shanghai Joiny Pharmaceutical Co.,LTD
2022-10-01	1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid 1335210-23-5	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2022-09-27	1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid 1335210-23-5	US $30.00-28.00 / Kg	1Kg	99.0% up	50 tons per month	Xinxiang Hongqi District Houyuan Trading Co.,Ltd

1-(2,2-Dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-2,5-pyridinedicarboxylic acid 2-methyl ester
1335210-23-5
US $0.00 / kg
98%
Shanghai Joiny Pharmaceutical Co.,LTD

1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
1335210-23-5
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
1335210-23-5
US $30.00-28.00 / Kg
99.0% up
Xinxiang Hongqi District Houyuan Trading Co.,Ltd

1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Spectrum

1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid(1335210-23-5)¹HNMR

1335210-23-5(1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid)Related Search:

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Bictegravir GSK1349572 2-BROMO-1-[4-HYDROXY-3-(HYDROXYMETHYL)PHENYL]ETHAN-1-ONE O-Methyl Dolutegravir 4-Acetoxy-3-acetoxymethylacetophenone

(6a,11b,16a,17a)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid (4R,12aS)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxylic acid N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine (2R,5S,13aR)-8-methoxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide

2,4,6-TRIFLUOROBENZYL AMINE (2R,5S,13aR)-8-methoxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxylic acid BIS(3,5-DIBROMOSALICYL) FUMARATE

1of4

1-(2,2-Dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-2,5-pyridinedicarboxylic acid 2-methyl ester 1-[2,2-bis(methyloxy)ethyl]-5-(methyloxy)-6-[(methyloxy)carbonyl]-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid 1-(2,2-diMethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Dulotegravir Me-N-4 2,5-Pyridinedicarboxylic acid, 1-(2,2-dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-, 2-methyl ester Dolutegravir Intermediates3 1-(2,2-Dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-2,5-pyridinedicarboxylic acid 2-methyl este 1-(2,2-dimethoxyethyl)-5-methoxy-4-oxo-1,4-dihydropyridine-3,6-dicarboxylic acid-6-methyl ester BNKY001-DL01 Bictegravir Intermediate (E) -2-(((2,2-dimethoxyethyl) amino) Methylene) -4-methoxy-3-oxobutanoic acid methyl ester Bictegravir Related Compound 1 (6-(methoxycarbonyl)-1,4-dihydro-5-methoxy-1-(2,2- dimethoxy ethyl)-4-oxopyridine-3-carboxylic acid) 1-(2,2-Dimethoxyethyl)-5-Methoxy-6-(Methoxycarbonyl)-4-oxo-1,4-Dihydropyridine-3-(Methoxycarbonyl)-4-oxo-1,4-Dihydropyridine-3-Carboxylic acid 1-(2,2-Dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-2,5-pyrid... Methyl 5-acetyl-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylate 1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxy 1-(2,2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid 1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid 1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid 1-(2,2-diMethoxyethy1)-5-Methoxy-6-(Methoxycarbony1)-4-oxo-1,4-dihydropyridine-3-carboxylic acid Dolutegravir Impurity 58 ( methoxycarbonyl ) -4 - oxo - 1,4 - dihydropyridine - 3 carboxylic Acid 1- ( 2,2 - Dimethoxyethyl ) -5 - methoxy - 6 1335210-23-5 13555210-23-5 CMLLYL