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SAR245409

SAR245409 Structure
SAR245409 structure
CAS No.
934493-76-2
Chemical Name:
SAR245409
Synonyms
CS-1242;Voxtalisib;XL-765;XL 765;Voxtalisib (XL-765);Voxtalisib (SAR245409);Voxtalisib (XL765, SAR245409);SAR245409 (XL765, Voxtalisib);Voxtalisib (SAR245409, XL765) Analogue;2-Amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7(8H)-one;2-Amino-8-ethyl-4-methyl-6-(1H-pyrazol-3-yl)pyrido[2,3-d]pyrimidin-7(8H)-one
CBNumber:
CB62715669
Molecular Formula:
C13H14N6O
Molecular Weight:
270.29
MDL Number:
MFCD20276656
MOL File:
934493-76-2.mol
MSDS File:
SDS
Last updated:2023-06-08 09:03:02
Request For Quotation

SAR245409 Properties

Boiling point 605.0±65.0 °C(Predicted)
Density 1.397±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 10 mg/mL (37.00 mM; Need ultrasonic)
form Powder
pka 12.54±0.10(Predicted)
FDA UNII CVL1685GPH

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P233-P260-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501
HS Code  29337900
NFPA 704
0
2 0

SAR245409 price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 30323 Voxtalisib 934493-76-2 5mg $117 2024-03-01 Buy
Cayman Chemical 30323 Voxtalisib 934493-76-2 50mg $578 2024-03-01 Buy
Cayman Chemical 30323 Voxtalisib 934493-76-2 10mg $176 2024-03-01 Buy
Cayman Chemical 30323 Voxtalisib 934493-76-2 25mg $347 2024-03-01 Buy
ChemScene CS-3163 Voxtalisib 99.46% 934493-76-2 5mg $84 2021-12-16 Buy
Product number Packaging Price Buy
30323 5mg $117 Buy
30323 50mg $578 Buy
30323 10mg $176 Buy
30323 25mg $347 Buy
CS-3163 5mg $84 Buy

SAR245409 Chemical Properties,Uses,Production

Definition

ChEBI: 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)-7-pyrido[2,3-d]pyrimidinone is a pyrazolopyridine.

Biological Activity

Voxtalisib (SAR245409, XL765) is a dual mTOR/PI3K inhibitor with the strongest effect on p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.

in vitro

Voxtalisib (XL765) is the first oral dual inhibitor of PI3K and mTOR with IC50 of 39, 113, 9, 43, and ~150 nM for p110α, β, γ, δ, and mTOR, respectively. In vitro, XL765 decreased cell viability in a concentration-dependent manner.

in vivo

Oral feeding of XL765 resulted in a 12-fold increase in the number of mid-stage tumor declines compared to the control group. XL765 showed activity either alone or in combination with other drugs in various GBM xenografts. XL765 induces downregulation of PI3K downstream phosphorylated proteins: pAkt and pPRAS40, and mTOR downstream phosphorylated proteins: pS6 and p4EBP1 in cultured human xenograft tumors in vitro.

target

PI3Kγ

SAR245409 synthesis

17119-73-2
934493-76-2
Synthesis of SAR245409 from 4-Chloro-6-methyl-2-(methylthio)pyrimidine

SAR245409 Preparation Products And Raw materials

Raw materials

6-bromo-8-ethyl-4-methyl-2-methylsulfanylpyrido[2,3-d]pyrimidin-7-one 5-Pyrimidinecarboxylic acid, 4-(ethylamino)-6-methyl-2-(methylthio)-, ethyl ester Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-6-bromo-8-ethyl-4-methyl- 5-Pyrimidinecarboxaldehyde, 4-(ethylamino)-6-methyl-2-(methylthio)- 5-Pyrimidinemethanol, 4-(ethylamino)-6-methyl-2-(methylthio)-
2-amino-8-ethyl-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one 8-ethyl-4-methyl-2-methylsulfanyl-6-(1H-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7-one 8-Ethyl-4-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one N-ethyl-5-iodo-6-methyl-2-(methylthio)pyrimidin-4-amine 2-amino-4-methyl-6-ethylaminopyrimidine
Ethyl 4-Chloro-6-methyl-2-(methylthio)pyrimidine-5-carboxylate 6-Methyl-2-(methylthio)pyrimidin-4-ol 4-Chloro-6-methyl-2-(methylthio)pyrimidine

1of3

Preparation Products

SAR245409 Suppliers

Global( 73)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24738 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 China 1494 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7553 61
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Career Henan Chemica Co 		58
InvivoChem 		58
LEAP CHEM CO., LTD. 		58
TargetMol Chemicals Inc. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
NCE Biomedical Co.,Ltd. 55
Haoyuan Chemexpress Co., Ltd. 61

934493-76-2(SAR245409)Related Search:

SAR 131675 SAR-020106 SAR-20347 SAR125844 SAR407899
Voxtalisib (XL-765) Voxtalisib (XL765, SAR245409) Voxtalisib 2-Amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7(8H)-one Voxtalisib (SAR245409) SAR245409 (XL765, Voxtalisib) Voxtalisib (SAR245409, XL765) Analogue CS-1242 XL-765;XL 765 Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-3-yl)- 2-Amino-8-ethyl-4-methyl-6-(1H-pyrazol-3-yl)pyrido[2,3-d]pyrimidin-7(8H)-one SAR-245409,SAR 245409,inhibit,Phosphoinositide 3-kinase,Mammalian target of Rapamycin,XL 765,mTOR,PI3K,Inhibitor,Voxtalisib,XL-765 934493-76-2