2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile
- CAS No.
- 1187595-85-2
- Chemical Name:
- 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile
- Synonyms
- 2-[1-(Ethylsulfonyl)-3-azetidinylidene]acetonitrile;Baricitinib-010;Baricitinib Intermediates;Baricitinib intermediate 2;[1-(ethylsulfonyl)azetidin-3-ylidene]acetonitrile;2-(1-ETHYLSULFONY)AZETIDIN-3-YLIDENE)ACETONITRILE;(1-Ethanesulfonyl-azetidin-3-ylidene)-acetonitrile;2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile;2-[1-(ethanesulfonyl)azetidin-3-ylidene]acetonitrile;2-[1-(ethyl sulfonyl) -3-azacyclobutyl] acetonitrile
- CBNumber:
- CB62715957
- Molecular Formula:
- C7H10N2O2S
- Molecular Weight:
- 186.23
- MDL Number:
- MFCD22987586
- MOL File:
- 1187595-85-2.mol
- MSDS File:
- SDS
Melting point | 67-69°C |
---|---|
Boiling point | 360.8±52.0 °C(Predicted) |
Density | 1.33±0.1 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | -8.49±0.20(Predicted) |
form | Solid |
color | Off-White to Light Yellow |
InChI | InChI=1S/C7H10N2O2S/c1-2-12(10,11)9-5-7(6-9)3-4-8/h3H,2,5-6H2,1H3 |
InChIKey | HQUIOHSYUKWGOM-UHFFFAOYSA-N |
SMILES | C(#N)/C=C1\CN(S(CC)(=O)=O)C\1 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H319-H335-H302+H312+H332-H315 |
Precautionary statements | P280-P301+P312-P362+P364 |
HS Code | 2933998090 |
2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | E926540 | 2-(1-(Ethylsulfonyl)azetidin-3-ylidene)acetonitrile | 1187595-85-2 | 5g | $275 | 2021-12-16 | Buy |
AK Scientific | 3147AH | 2-[1-(Ethanesulfonyl)azetidin-3-ylidene]acetonitrile | 1187595-85-2 | 25g | $206 | 2021-12-16 | Buy |
Apolloscientific | OR921330 | 2-(1-(Ethylsulfonyl)azetidin-3-ylidene)acetonitrile 97% | 1187595-85-2 | 25g | $243 | 2021-12-16 | Buy |
ChemScene | CS-M2446 | 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile | 1187595-85-2 | 25g | $75 | 2021-12-16 | Buy |
AK Scientific | J95359 | 2-[1-(Ethanesulfonyl)azetidin-3-ylidene]acetonitrile | 1187595-85-2 | 25g | $160 | 2021-12-16 | Buy |
2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile Chemical Properties,Uses,Production
Uses
2-(1-(Ethylsulfonyl)azetidin-3-ylidene)acetonitrile is an intermediate in the synthesis of Baricitinib, a JAK 1 and 2 inhibitor used in the treatment of rheumatoid arthritis.
Synthesis
2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile is synthesized by first treating azetidine-3-ol hydrochloride with an equimolar equivalent of an alkanesulfonyl chloride, preferably ethanesulfonyl chloride, to give l-ethylsulfonylazetidin-3-ol. Preferably, the reaction is performed in a biphasic solution comprising a mixture of an organic phase and a aqueous phase, preferably THF with an aqueous solution which is basic, while maintaining the solution at room temperature or a temperature slightly below room temperature, preferably 20 °C. The reaction is followed to completion using standard monitoring techniques. Typically, the reaction is complete within 1 to 5 hours. The organic layer is removed, preferably by distillation, and the aqueous layer is extracted with an appropriate solvent such as toluene, p-cymene, and CPME. Preferably the extraction solvent is toluene. Alternatively, the toluene extractions can be excluded if recrystallization of 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile is performed.
2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Jinli Pharmaceutical Co.,Ltd | +86-21-57256005 +86-15921811235 | chang@shjlchem.com | China | 20 | 58 |
Jinan Million Pharmaceutical Co., Ltd | +86-531-68659554 +8613031714605 | info@millionpharm.com | China | 154 | 58 |
Hangzhou ICH Biofarm Co., Ltd | +undefined8613073685410 | sales@ichemie.com | China | 985 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 906 | 58 |
View Lastest Price from 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-26 | 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile
1187595-85-2
|
US $2.00 / kg | 1kg | 99% | 1200KG/M | Jinan Million Pharmaceutical Co., Ltd | ||
2024-04-10 | 2-[1-(Ethylsulfonyl)-3-azetidinylidene]acetonitrile
1187595-85-2
|
US $0.00 / kg | 1kg | 99% | 200kg | Shanghai Joiny Pharmaceutical Co.,LTD | ||
2023-12-29 | 2-(1-(Ethylsulfonyl)azetidin-3-ylidene)acetonitrile
1187595-85-2
|
US $0.00-0.00 / kg | 1kg | 98% | 1 ton | Nanjing Fred Technology Co., Ltd |
- 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile
1187595-85-2
- US $2.00 / kg
- 99%
- Jinan Million Pharmaceutical Co., Ltd
- 2-[1-(Ethylsulfonyl)-3-azetidinylidene]acetonitrile
1187595-85-2
- US $0.00 / kg
- 99%
- Shanghai Joiny Pharmaceutical Co.,LTD
- 2-(1-(Ethylsulfonyl)azetidin-3-ylidene)acetonitrile
1187595-85-2
- US $0.00-0.00 / kg
- 98%
- Nanjing Fred Technology Co., Ltd