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Bosutinib Monohydrate

Bosutinib Monohydrate Structure
Bosutinib Monohydrate structure
CAS No.
918639-08-4
Chemical Name:
Bosutinib Monohydrate
Synonyms
bosutinib hydrate;Bosutinib Monohydrate;Bosutinib MonohydrateQ: What is Bosutinib Monohydrate Q: What is the CAS Number of Bosutinib Monohydrate
CBNumber:
CB62728577
Molecular Formula:
C26H31Cl2N5O4
Molecular Weight:
548.47
MDL Number:
MFCD29920031
MOL File:
918639-08-4.mol
Last updated:2023-05-04 15:14:14
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Bosutinib Monohydrate Properties

FDA UNII 844ZJE6I55

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
Signal word  Warning
Hazard statements  H400-H410-H317
Precautionary statements  P273-P391-P501-P273-P391-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501

Bosutinib Monohydrate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth Carbosynth FB145112 Bosutinib monohydrate 918639-08-4 100mg $120 2021-12-16 Buy
Biosynth Carbosynth FB145112 Bosutinib monohydrate 918639-08-4 250mg $200 2021-12-16 Buy
Biosynth Carbosynth FB145112 Bosutinib monohydrate 918639-08-4 1g $400 2021-12-16 Buy
AK Scientific 4958BB Bosutinibmonohydrate 918639-08-4 500mg $455 2021-12-16 Buy
Product number Packaging Price Buy
FB145112 100mg $120 Buy
FB145112 250mg $200 Buy
FB145112 1g $400 Buy
4958BB 500mg $455 Buy

Bosutinib Monohydrate Chemical Properties,Uses,Production

Definition

ChEBI: A hydrate that is the monohydrate form of anhydrous bosutinib.

Clinical Use

Bosulif ® (Bosutinib hydrate), also known as (SKI-606), is a novel 4-phenylamino-3-quinolinecarbonitrile kinase inhibitor approved for treatment of adults with chronic, accelerated, or blast phase Philadelphia chromosome-positive chronic myeloid leukemia (Ph+CML). Bosutinib is an orally-dosed, dual Src/Abl kinase inhibitor which provides an alternative treatment to patients exhibiting immunity to imatinib and other kinase inhibitors utilized for this treatment. In contrast to competitor tyrosine inhibitors, bosutinib inhibits autophosphorylation of both Srs and Abl kinases, leading to decreased cell growth and apoptosis. Bosutinib was originally developed by Wyeth and continues to be marketed by Pfizer after the merger of Wyeth and Pfizer in 2009.

Synthesis

Several synthetic routes to bosutinib have been reported, including synthetic work for scale up and processing to obtain pure salt forms of bosutinib for pharmaceutical applications.56-59 The current manufacturing route begins with reaction of 2-methoxy-5-nitrophenol (36) and 1-bromo-3- chloropropane (37) to provide aryl chloroether 38 in 82% yield. Reaction of 38 with Nmethylpiperazine (39) and NaI in refluxing DME provided the functionalized aryl-nitro-piperazine 40 (77% yield), which was converted directly to aniline 41 under hydrogenolysis conditions. Aniline 41 was then reacted with triethyl orthoformate and aryl cyanoamide 42, which was generated in one step from 2,4-dichloro-5-methoxy-aniline (44), 1,3-diisopropylcabodiimide (DIC), and cyanoacetic acid (45) under refluxing conditions, to yield advanced intermediate 43 (93% over 2 steps). Finally, conversion of 43 to bosutinib was facilitated by a POCl3-promoted cyclization in the presence of sulfolane. As shown in Scheme 8, employment of carefully optimized conditions for the isolation of bosutinib hydrate (VII) provided material in 75-82% yields and >99% purity.

Synthesis_918639-08-4

Bosutinib Monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Bosutinib Monohydrate Suppliers

Global( 73)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Zhejiang ZETian Fine Chemicals Co. LTD 		18957127338 stella@zetchem.com China 2141 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Shanghai Jinghao Pharmaceutical Co.,Ltd 		+86-21-68900963 sales@jinghaopharma.com CHINA 153 58
Shanghai Yingrui Biopharma Co.,Ltd 		21-33585366 export01@shyrchem.com CHINA 1320 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10326 58
AFINE CHEMICALS LIMITED 		0571-85134551 info@afinechem.com CHINA 15377 58
Baoji Guokang Healthchem co.,ltd 		+8615604608665 15604608665 dominicguo@gk-bio.com CHINA 9427 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Chongqing Chemdad Co., Ltd 		58
Shanghai Jinghao Pharmaceutical Co.,Ltd 		58
Shanghai Yingrui Biopharma Co.,Ltd 		58
Hubei Ipure Biology Co., Ltd 		58
AFINE CHEMICALS LIMITED 		58
Baoji Guokang Healthchem co.,ltd 		58
InvivoChem 		58

View Lastest Price from Bosutinib Monohydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Bosutinib Monohydrate pictures 2019-07-06 Bosutinib Monohydrate
918639-08-4
 US $2.00 / kg 1kg 99% ask Career Henan Chemical Co

918639-08-4(Bosutinib Monohydrate)Related Search:

5-Amino-2,4-dichloroanisole 2-aMino-4-(3-chloropropoxy)-5-Methoxybenzoate 4-CHLORO-7-(3-CHLORO-PROPOXY)-6-METHOXY-QUINOLINE-3-CARBONITRILE Methyl 4-(3-chloropropoxy)-5-Methoxy-2-nitrobenzoate 7-(3-CHLORO-PROPOXY)-4-(2,4-DICHLORO-5-METHOXY-PHENYLAMINO)-6-METHOXY-QUINOLINE-3-CARBONITRILE
Bosutinib 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxy- 1-[3-(2-Methoxy-5-nitrophenoxy)propyl]-4-Methylpiperazine N-(2,4-DICHLORO-5-HYDROXYPHENYL)ACETAMIDE
4-Methoxy-3-(3-(4-Methylpiperazin-1-yl)propoxy)aniline 4-CHLORO-7-FLUORO-6-METHOXY-QUINOLINE-3-CARBONITRILE 4-CHLORO-7-HYDROXY-6-METHOXY-QUINOLINE-3-CARBONITRILE 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE

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Bosutinib Monohydrate bosutinib hydrate Bosutinib MonohydrateQ: What is Bosutinib Monohydrate Q: What is the CAS Number of Bosutinib Monohydrate 918639-08-4 C26H31Cl2N5O4 C26H29Cl2N5O3H2O