LGD-2226
- CAS No.
- 328947-93-9
- Chemical Name:
- LGD-2226
- Synonyms
- LGD-2226;LGD-2226 (LGD2226);6-[Bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-2(1H)-quinolinone;6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-1H-quinolin-2-one;2(1H)-Quinolinone, 6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-
- CBNumber:
- CB62750752
- Molecular Formula:
- C14H9F9N2O
- Molecular Weight:
- 392.22
- MDL Number:
- MFCD15146764
- MOL File:
- 328947-93-9.mol
| Melting point | 187-190°C |
|---|---|
| Boiling point | 364.4±42.0 °C(Predicted) |
| Density | 1.526±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.88±0.70(Predicted) |
| color | Pale Yellow to Light Yellow |
| BRN | 10716241 |
| InChI | InChI=1S/C14H9F9N2O/c15-12(16,17)5-25(6-13(18,19)20)7-1-2-10-8(3-7)9(14(21,22)23)4-11(26)24-10/h1-4H,5-6H2,(H,24,26) |
| InChIKey | ULBPQWIGZUGPHU-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(N(CC(F)(F)F)CC(F)(F)F)C=C2)C(C(F)(F)F)=CC1=O |
| FDA UNII | RI376RM5MT |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H373 |
| Precautionary statements | P260-P314-P501 |
| Hazard Codes | Xn |
| Risk Statements | 48/22 |
| WGK Germany | 3 |
| RTECS | VC8275240 |
LGD-2226 price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 07682 | 6-[Bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl)-2(1H)-quinolinone analytical standard | 328947-93-9 | 25mg | $744 | 2024-03-01 | Buy |
| TRC | L397615 | LGD-2226 | 328947-93-9 | 5mg | $110 | 2021-12-16 | Buy |
| TRC | L397615 | LGD-2226 | 328947-93-9 | 10mg | $180 | 2021-12-16 | Buy |
| TRC | L397615 | LGD-2226 | 328947-93-9 | 100mg | $1390 | 2021-12-16 | Buy |
| DC Chemicals | DC22137 | LGD2226 >98% | 328947-93-9 | 1g | $1600 | 2021-12-16 | Buy |
LGD-2226 Chemical Properties,Uses,Production
Uses
LGD-2226 is an orally active potent and selective androgen receptor modulator used in the treatment of muscle wasting and osteoporosis. Show to have an anabolic effect on muscle and bone tissue.
Synthesis
A 2 L round flask, under argon, was charged with a solution of the 14.00 g amine( 6-Amino-4-trifluoromethylquinolin-2(1H)-one )in 350 ml trifluoroacetic acid. 5.80 g NaBH4 was added within 1 h. The mixture was stirred at room temperature for 16 h. After that 4.50 g NaBH4 was added and then heated to 70°C for 5 h. The heating bath was removed and it was stirred at room temperature over 2 d. In several portions water was carefully added. In total 1500 ml water was slowly added. The yellow-greenish precipitate was filtered and rinsed with water. After drying, the crude product was purified by column chromatography on silica gel by using hexane-ethyl acetate (1:4), followed by a recrystallization in chloroform. 18.1 g of LGD-2226 was obtained as a bright yellow solid (76%).
LGD-2226 Preparation Products And Raw materials
Raw materials
Preparation Products
LGD-2226 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Ruichi Technology Co., Ltd | +8613545065237 | admin@whrchem.com | China | 164 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5994 | 58 |
| Dorne Chemical Technology co. LTD | +86-13583358881 +86-18560316533 | Ethan@dornechem.com | China | 293 | 58 |
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 436 | 58 |
| Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1100 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
| Shanghai Aosiris new Material Technology Co., LTD | 86-15139564871 +8615139564871 | wrjmoon2000@163.com | China | 357 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
View Lastest Price from LGD-2226 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-05-08 | LGD-2226
328947-93-9
|
US $1.00-1.00 / g | 1g | 99% | 100kg | Dorne Chemical Technology co. LTD | |
 |
2024-04-19 | LGD-2226
328947-93-9
|
US $3.00-1.00 / kg | 1kg | 99.9% | 10 tons | Shanghai Aosiris new Material Technology Co., LTD | |
 |
2024-04-12 | LGD-2226
328947-93-9
|
US $0.00 / kg | 1kg | 0.99 | 10T | Shandong Hanjiang Chemical Co., Ltd |