ChemicalBook >> CAS DataBase List >>L-Penicillamine

L-Penicillamine

CAS No.
1113-41-3
Chemical Name:
L-Penicillamine
Synonyms
l-valin;H-PEN-OH;3-MERCAPTO-L-VALINE;3,3-DIMETHYL-L-CYSTEINE;L-Pen-OH;L-(+)-B2;NSC 241261;3-Mercapto-;3-THIOL-VALINE;-Penicillamine
CBNumber:
CB6302922
Molecular Formula:
C5H11NO2S
Molecular Weight:
149.21
MDL Number:
MFCD00064303
MOL File:
1113-41-3.mol
MSDS File:
SDS
Last updated:2023-04-23 13:52:06

L-Penicillamine Properties

Melting point 206 °C (dec.)(lit.)
Boiling point 251.8±35.0 °C(Predicted)
alpha 61.9 º (C=0.5 IN 1 M NAOH)
Density 1.113 (estimate)
refractive index 63 ° (C=1, 1mol/L NaOH)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Aqueous Base (Sparingly), DMSO (Slightly, Heated), Water (Slightly)
pka 2.13±0.12(Predicted)
form Crystalline Powder
color White to almost white
optical activity [α]24/D +61.9°, c = 0.5 in 1 M NaOH
Merck 14,7088
BRN 1722374
Stability Hygroscopic
InChIKey VVNCNSJFMMFHPL-GSVOUGTGSA-N
CAS DataBase Reference 1113-41-3(CAS DataBase Reference)
FDA UNII NO1YIB7OIG

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Danger
Hazard statements  H302-H315-H319-H335
Precautionary statements  P280h-P305+P351+P338
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-40-20/21/22
Safety Statements  26-36-22-24/25
WGK Germany  2
RTECS  YV9445500
HS Code  29309090
Toxicity LD50 i.p. in rats: 350 mg/kg (Jaffe)
NFPA 704
1
2 0

L-Penicillamine price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 196312 L-Penicillamine 99% 1113-41-3 1g $77.7 2024-03-01 Buy
Sigma-Aldrich 196312 L-Penicillamine 99% 1113-41-3 5g $264 2024-03-01 Buy
TCI Chemical P1370 L-Penicillamine >98.0%(T) 1113-41-3 1g $43 2021-12-16 Buy
TCI Chemical P1370 L-Penicillamine >98.0%(T) 1113-41-3 5g $93 2021-12-16 Buy
Alfa Aesar L13923 L-(+)-Penicillamine, 98+% 1113-41-3 250mg $0 2021-12-16 Buy
Product number Packaging Price Buy
196312 1g $77.7 Buy
196312 5g $264 Buy
P1370 1g $43 Buy
P1370 5g $93 Buy
L13923 250mg $0 Buy

L-Penicillamine Chemical Properties,Uses,Production

Chemical Properties

white to almost white crystalline powder

Uses

Metal-chelating agent

Uses

As a Penicillin metabolite, L-Penicillamine can be used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.

Uses

L-Penicillamine is a metabolite of penicillin. L-Penicillamine is used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.

Indications

Penicillamine (Cuprimine) can be used to treat acute, severe rheumatoid arthritis, producing reductions in joint pain, edema, and stiffness.The response to penicillamine is usually delayed (4–12 weeks), and remissions can last several months after withdrawal of treatment. Radiographic evidence of this drug’s efficacy is limited; thus, penicillamine is seldom used to treat rheumatoid arthritis.

Definition

ChEBI: The L-enantiomer of penicillamine.

Mechanism of action

The mechanism of action of penicillamine is unknown, but some evidence suggests that it may involve the inhibition of angiogenesis, synovial fibroblast proliferation, or transcriptional activation. Because penicillamine can chelate copper and promote its excretion, it is used to treat Wilson’s disease (hepatolenticular degeneration) and has also been used in mercury and lead intoxication.

Pharmacology

Penicillamine is readily absorbed from the GI tract and is rapidly excreted in the urine, largely as the intact molecule. Gradually increasing its dose minimizes side effects, which necessitate discontinuance of penicillamine therapy in perhaps one-third of patients. The most common side effects are maculopapular pruritic dermatitis, GI upset, loss of taste sensation, mild to occasionally severe thrombocytopenia and leukopenia,and mild proteinuria, which at times may progress to the nephritic syndrome. Discontinuance of therapy usually results in a rapid disappearance of side effects.

Safety Profile

A poison by intraperitoneal route. Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx and SOx.

Purification Methods

Same as preceding entry for its enantiomer. [Beilstein 4 IV 3228.]

L-Penicillamine Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 211)Suppliers
Supplier Tel Email Country ProdList Advantage
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.
+86-18616643091 +86-18616643091 info@rochipharma.com China 246 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9354 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Zhejiang ZETian Fine Chemicals Co. LTD
18957127338 stella@zetchem.com China 2141 58
Jinan Carbotang Biotech Co.,Ltd.
+8615866703830 figo.gao@foxmail.com China 8136 58
Shandong chuangyingchemical Co., Ltd.
18853181302 sale@chuangyingchem.com CHINA 5909 58
Standardpharm Co. Ltd.
86-714-3992388 overseasales1@yongstandards.com United States 14336 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58

View Lastest Price from L-Penicillamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-penicillamine pictures 2024-03-28 L-penicillamine
1113-41-3
US $0.00 / KG 25KG 98% Inquiry PNP Biotech Co. Ltd
L-Penicillamine pictures 2021-07-13 L-Penicillamine
1113-41-3
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
L-Penicillamine pictures 2021-07-09 L-Penicillamine
1113-41-3
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
  • L-Penicillamine pictures
  • L-Penicillamine
    1113-41-3
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • L-Penicillamine pictures
  • L-Penicillamine
    1113-41-3
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
3-THIOL-VALINE TIMTEC-BB SBB000102 L-BETA,BETA-DIMETHYLCYSTEINE L-BETA-MERCAPTOVALINE L-(+)-PENICILLAMINE L-PENICILLAMINE L(+)-2-AMINO-3-MERCAPTO-3-METHYLBUTANOIC ACID H-BETA,BETA-DIMETHYL-CYS-OH H-CYS(3-ME 2)-OH BETA,BETA-DIMETHYL-L-CYSTEINE PENICILLAMINE(L-) L-Penicillamine L-Penicillamine≥ 99.0% (Titration: anhydrous basis) 3-mercapto-l-valin L-(+)-PENICILLAMINE, 98+% L-PENICILLAMINE 99.5+% 3,3-Dimethyl-L-cysteine~3-Mercapto-L-valine (R)-Penicillamine L-Valine, 3-mercapto- (9CI) NSC 241261 Valine, 3-mercapto-, L- (8CI) 3,3-Dimethyl-L-cysteine, 3-Mercapto-L-valine, L-(+)-2-Amino-3-mercapto-3-methylbutanoic acid 3,3-Dimethyl-L-cysteine, 3-Mercapto-L-valine, L-(+)-2-Amino-3-mercapto-3-methylbutanoic acid β,β-Dimethyl-L-cysteine [R,(+)]-2-Amino-3-mercapto-3-methylbutyric acid L-(+)-β-mercaptovaline 3-Mercapto- L-PenicillaMine-d6 L-beta,beta-Dimethylcysteine L-beta-Mercaptovaline H-b,b-DiMethyl-Cys-OH, H-b-Mercapto-Val-OH L-Pen-OH L-PenicillaMine 99% Penicillamine Impurity 4(L-Penicillamine) (2R)-2-amino-3-methyl-3-sulfanylbutanoic acid L-Penicillamine> L-Valine, 3-mercapto- L-Penicillamine ISO 9001:2015 REACH L-(+)-B2 -mercaptovaline 3-MERCAPTO-L-VALINE 3,3-DIMETHYL-L-CYSTEINE H-PEN-OH l-valin 3-Sulfanyl-L-Valine L-(+)-β-mercaptovaline -Penicillamine L-PENCILLAMINE 1113-41-3 AMINE Specialty Synthesis Peptide Synthesis Unnatural Amino Acid Derivatives Amino Acids & Derivatives Intermediates & Fine Chemicals Pharmaceuticals Amino Acids Biochemistry non-Proteinorganic Amino Acids 1