RNA Polymerase III Inhibitor
- CAS No.
- 577784-91-9
- Chemical Name:
- RNA Polymerase III Inhibitor
- Synonyms
- RNA Polymerase III Inhibitor;RNA Polymerase III Inhibitor inhibitor;RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem;InSolution RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem;2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide;Benzenesulfonamide, 2-chloro-N-[3-(5-chloro-3-methylbenzo[b]thien-2-yl)-1-methyl-1H-pyrazol-5-yl]-;transcription,inhibit,broad-spectrum,ML-60218,Inhibitor,viroplasms,ML 60218,yeast,DNA/RNA Synthesis,ML60218
- CBNumber:
- CB63136764
- Molecular Formula:
- C19H15Cl2N3O2S2
- Molecular Weight:
- 452.38
- MDL Number:
- MFCD00112663
- MOL File:
- 577784-91-9.mol
- MSDS File:
- SDS
| storage temp. | = -70C |
|---|---|
| solubility | Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 5 mg/ml with warming) |
| form | Off-white solid |
| color | Off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
RNA Polymerase III Inhibitor price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 557403 | RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem RNA Polymerase III Inhibitor, CAS 577784-91-9, is a cell-permeable inhibitor of RNA Polymerase III (IC = 27 and 32 μM for human and S. cerevisiae RNA Pol III, respectively). |
577784-91-9 | 10mg | $403 | 2024-03-01 | Buy |
| ChemScene | CS-0081935 | ML-60218 ≥99.0% | 577784-91-9 | 25mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0081935 | ML-60218 ≥99.0% | 577784-91-9 | 50mg | $850 | 2021-12-16 | Buy |
| ChemScene | CS-0081935 | ML-60218 ≥99.0% | 577784-91-9 | 100mg | $1350 | 2021-12-16 | Buy |
| ChemScene | CS-0081935 | ML-60218 ≥99.0% | 577784-91-9 | 5mg | $150 | 2021-12-16 | Buy |
RNA Polymerase III Inhibitor Chemical Properties,Uses,Production
Description
ML60218 (CAS 577784-91-9) is a broad spectrum inhibitor of RNA polymerase III from?S. Cerevisiae?as well as from human cells, IC50=32?mM and 27?mM respectively.1?? Combined treatment with ML-60218 and an HDAC inhibitor caused augmented suppression of colony formation, induction of cell cycle arrest and apoptotic cell death in human pancreatic adenocarcinoma cells.2
General Description
A cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III (IC50 = 27 and 32 μM for human and S. cerevisiae RNA Pol III, respectively). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. Also available as a 25 mM solution in DMSO (Cat. No. 557404).
Biochem/physiol Actions
Product does not compete with ATP.
References
1) Wu?et al.?(2003),?Novel small-molecule inhibitors of RNA polymerase III; Eukaryot. Cell,?2?256 2) Yee?et al.?(2012),?Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer; Biol. Open,?1(4)?295
RNA Polymerase III Inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
RNA Polymerase III Inhibitor Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29796 | 68 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9180 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12007 | 58 |