ChemicalBook >> CAS DataBase List >>HIF-2a Translation Inhibitor 76
HIF-2a Translation Inhibitor 76
- CAS No.
- 882268-69-1
- Chemical Name:
- HIF-2a Translation Inhibitor 76
- Synonyms
- HIF-2α-IN-4;HIF-2α Translation Inhibitor;HIF-2a translation inhibitor;HIF-2a Translation Inhibitor 76;2-Thiophenecarboxylic acid, 3-[[cyano(methylsulfonyl)methylene]hydrazinyl]-, methyl ester;HIF 2α IN 4,iron-responsive,oxygen sensing,HIF-2α,HIF/HIF Prolyl-Hydroxylase,translation,HIF-PH,hypoxia,HIF2αIN4,inhibit,HIFs,Hypoxia-inducible factors,Inhibitor
- CBNumber:
- CB63146303
- Molecular Formula:
- C9H9N3O4S2
- Molecular Weight:
- 287.32
- MDL Number:
- MFCD30861484
- MOL File:
- 882268-69-1.mol
Last updated:2023-09-04 15:51:00
HIF-2a Translation Inhibitor 76 price
HIF-2a Translation Inhibitor 76 Chemical Properties,Uses,Production
Biological Activity
HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5’UTR iron-responsive element to oxygen sensing[1]. HIF-2α-IN-4 (compound 76) (10 μM; 786-O cells) decreases HIF-2α mRNA translation in an mTOR-independent manner[1].HIF-2α-IN-4 decreases HIF-2α protein and HIF-2α target gene expression in normoxia and hypoxia[1].
References
[1]. Zimmer M, et al. Small-molecule inhibitors of HIF-2α translation link its 5’UTR iron-responsive element to oxygen sensing. Mol Cell. 2008;32(6):838-848.
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HIF-2a Translation Inhibitor 76
HIF-2a translation inhibitor
HIF-2α-IN-4
HIF 2α IN 4,iron-responsive,oxygen sensing,HIF-2α,HIF/HIF Prolyl-Hydroxylase,translation,HIF-PH,hypoxia,HIF2αIN4,inhibit,HIFs,Hypoxia-inducible factors,Inhibitor
2-Thiophenecarboxylic acid, 3-[[cyano(methylsulfonyl)methylene]hydrazinyl]-, methyl ester
HIF-2α Translation Inhibitor
882268-69-1