ChemicalBook >> CAS DataBase List >>5-Fluoroorotic acid
5-Fluoroorotic acid
- CAS No.
- 703-95-7
- Chemical Name:
- 5-Fluoroorotic acid
- Synonyms
- foa;fo;5-FOA;5-Fluoro-2,6-dioxo-1,2,3,6-tetrahydropyriMidine-4-carboxylic acid;5' FOA;ro2-9945;nsc31712;Fluoxydin;ent-26398;WR 152520
- CBNumber:
- CB6325772
- Molecular Formula:
- C5H3FN2O4
- Molecular Weight:
- 174.09
- MDL Number:
- MFCD00042526
- MOL File:
- 703-95-7.mol
Last updated:2023-04-24 11:54:38
| Melting point | 278 °C (dec.)(lit.) |
|---|---|
| Boiling point | 143°C (rough estimate) |
| Density | 1.6154 (estimate) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | NH4OH 4 M: 50 mg/mL, clear, faintly yellow |
| pka | 2.04±0.20(Predicted) |
| form | solid |
| color | Pale yellow |
| Merck | 14,4176 |
| InChIKey | LODRRYMGPWQCTR-UHFFFAOYSA-N |
| CAS DataBase Reference | 703-95-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 7IA9OUC93E |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P264-P270-P301+P312+P330-P501-P261-P305+P351+P338 |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36-36/37/39-27 |
| WGK Germany | 3 |
| RTECS | UV7800000 |
| F | 10 |
| HazardClass | IRRITANT |
| HS Code | 29335990 |
5-Fluoroorotic acid price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0382 | 5-Fluoroorotic Acid Monohydrate >95.0%(HPLC)(T) | 703-95-7 | 1g | $40 | 2021-12-16 | Buy |
| TCI Chemical | F0382 | 5-Fluoroorotic Acid Monohydrate >95.0%(HPLC)(T) | 703-95-7 | 100mg | $10 | 2021-12-16 | Buy |
| Apolloscientific | PC408010 | 5-Fluorooroticacid | 703-95-7 | 1g | $42 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H53-3-25 | 5-Fluoroorotic acid 99% | 703-95-7 | 1g | $55 | 2021-12-16 | Buy |
| Apolloscientific | PC408010 | 5-Fluorooroticacid | 703-95-7 | 5g | $77 | 2021-12-16 | Buy |
5-Fluoroorotic acid Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Crystalline Solid
Uses
5-FOA(5-Fluoroorotic acid ) has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in malarial parasites. The combination of 5-FOA and uracil has been effective in treating mice infected with Plasmodium yoelli. 5-FOA may also have potential in the treatment of human malarial infections when used in combination with other agents.
Uses
Useful in the selection of orotidine-5′-phosphate decarboxylase mutants of Saccharomyces cerevisiae.
5-Fluoroorotic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 324)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
| Nanjing Baifuli Technology Co., Ltd. | +86-15335185688 | sales@unisyn.cn | CHINA | 332 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5909 | 58 |
| Changzhou Carman Chemical Co., Ltd. | 15061933924 | CHINA | 514 | 58 | |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10828 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
View Lastest Price from 5-Fluoroorotic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-04-25 | 5-Fluoroorotic acid
703-95-7
|
US $100.00 / kg | 1kg | 99% | 100 tons | Hebei Duling International Trade Co. LTD | |
 |
2023-03-06 | 5-Fluoroorotic Acid
703-95-7
|
US $10.00 / Kg/Drum | 1KG | 98% | 10 ton | Hebei Guanlang Biotechnology Co,.LTD | |
 |
2021-07-13 | 5-Fluoroorotic acid
703-95-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 5-Fluoroorotic acid
703-95-7
- US $100.00 / kg
- 99%
- Hebei Duling International Trade Co. LTD
-
- 5-Fluoroorotic Acid
703-95-7
- US $10.00 / Kg/Drum
- 98%
- Hebei Guanlang Biotechnology Co,.LTD
-
- 5-Fluoroorotic acid
703-95-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
703-95-7(5-Fluoroorotic acid )Related Search:
1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylicaci
1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylicacid
nsc31712
ro2-9945
2,6-Dihydroxy-5-fluoropyrimidine-4-carboxylic acid
5-FLUOROURACIL-4-CARBOXYLIC ACID
5' FOA
5-FLUORO-2,6-DIOXO-3H-PYRIMIDINE-4-CARBOXYLIC ACID
5-FLUOROORTIC ACID
5-Fluoroorotic
Fluoxydin
Fluoroorotic-Acid (5' FOA)
5-fluorouracil-6-carboxylic acid
5-Fluoroorotic acid monohydrate 98%
5-Fluorooroticacidmonohydrate98%
RARECHEM AH BS 0043
5-FLUOROOROTIC ACID HYDRATE 99%
4-PYRIMIDINECARBOXYLICACID,5-FLUORO-1,2,3,6-TETRAHYDRO-2,6-DIOXO
5-fluoro-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylicaci
5-fluoroorotate
5-fluoro-oroticaci
ent-26398
fluorooroticacid
4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-
WR 152520
5-Fluoro-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid
5-Fluoro-2,6-dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylic acid
5-Fluoroorotic acid anhydrous
5-Fluoroorotic acid,5-FOA
5-Fluoroorotic Acid
5-Fluoroorotic acid, 98.0%+
5-Fluoroorotic acid hydrate AldrichCPR
2,6-Dihydroxy-5-fluor-pyrimidin-4-carbonsure 5-Fluor-uracil-4-carbonsure
5-FLUOROOROTIC ACID
5-fluoro-2,4-dioxo-1H-pyrimidine-6-carboxylic acid hydrate
5-FOA, 5-Fluoroorotic acid
5-FluorooroticAcidMonohydrate>
uoroorotic acid hydrate
5-Fluoroorotic Acid (5-FOA) for molecular biology, 98%
5-FOA
fo
foa
5-Fluoro-2,6-dioxo-1,2,3,6-tetrahydropyriMidine-4-carboxylic acid
5-fluorowhey acid
703-95-7
C5H5FN2O5H2O
C5H5FN2O5
C5H3FN2O4.H2O
C5H3FN2O4
C5H3FN2O4xH2O
Activity
Fluorogenic
pyrimidine
Fluorine series
Nucleotides and Nucleosides
Biochemistry
Nucleobases and their analogs
Nucleosides, Nucleotides & Related Reagents