ChemicalBook >> CAS DataBase List >>2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE

2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE

2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE structure

CAS No.: 349085-38-7

Chemical Name:: 2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE

Synonyms: CS-828;HC 030031;HC 030031 1G;TOSLAB 829227;HC030031; HC 030031;HC-030031 (TOSLAB-829227);TrpA1 Antagonist, HC-030031;HC-030031;HC 030031;HC030031;TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem;2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurin-7-yl)aceta...

CBNumber:: CB6334374

Molecular Formula:: C18H21N5O3

Molecular Weight:: 355.39

MDL Number:: MFCD02007349

MOL File:: 349085-38-7.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

Request For Quotation

2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE Properties

Melting point	221-223°C
Density	1.33±0.1 g/cm3(Predicted)
storage temp.	room temp
solubility	DMSO: soluble10mg/mL, clear
pka	13.71±0.70(Predicted)
form	White solid
color	white to beige
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey	HEQDZPHDVAOBLN-UHFFFAOYSA-N
FDA UNII	MU78VFH9C7

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301

Precautionary statements

P264-P270-P301+P310-P321-P330-P405-P501

Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN 2811 6.1 / PGIII

WGK Germany

NFPA 704

	0
2		0

2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H4415	HC-030031 ≥98% (HPLC), powder	349085-38-7	10mg	$150	2024-03-01	Buy
Sigma-Aldrich	H4415	HC-030031 ≥98% (HPLC), powder	349085-38-7	50mg	$589	2024-03-01	Buy
Cayman Chemical	11923	HC-030031 ≥98%	349085-38-7	5mg	$28	2024-03-01	Buy
Cayman Chemical	11923	HC-030031 ≥98%	349085-38-7	10mg	$48	2024-03-01	Buy
Cayman Chemical	11923	HC-030031 ≥98%	349085-38-7	50mg	$140	2024-03-01	Buy

Product number	Packaging	Price	Buy
H4415	10mg	$150	Buy
H4415	50mg	$589	Buy
11923	5mg	$28	Buy
11923	10mg	$48	Buy
11923	50mg	$140	Buy

2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE Chemical Properties,Uses,Production

Description

Transient receptor potential cation channel A₁ (TRPA1) is an ankyrin-like ion channel which acts as a sensor for chemical irritants, pain, and cold. It is activated by allyl isothiocyanate (AITC), formalin, hydrogen peroxide, tear gas, and other compounds. HC-030031 is a selective TRPA1 blocker, antagonizing TRPA1-mediated calcium influx induced by AITC and formalin (IC₅₀s = 6.2 and 5.3 μM, respectively). It does not block currents mediated by TRPV1, TRPV3, TRPV4 hERG, or Na_V1.2 channels. HC-030031 can be used in cells or delivered to animals orally, by inhalation, or by injection. Oral administration (100 mg/kg) of HC-030031 significantly reversed mechanical hypersensitivity in rat models of chronic inflammatory or neuropathic pain, while local injection (100 μg) into inflamed mouse hind paws attenuated mechanical, but not heat, hypersensitivity.

Chemical Properties

White Solid

Uses

A TRPA1 (transient receptor potential) selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity.

Biological Activity

Selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx (IC 50 values are 6.2 and 5.3 μ M respectively). Does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG or Na V 1.2 channels. Inhibits AITC- and formalin-induced flinching in vivo .

Biochem/physiol Actions

HC-030031 is a selective TRPA1 channel blocker, antagonizing formalin-evoked calcium influx and formalin-induced pain. IC50 is 5 μM. TRPA1 antagonism is a promising therapeutic target for chronic inflammatory or neurogenic pain.

storage

Room temperature

References

1) McNamara et al. (2007), TRPA1 mediates formalin-induced pain; Proc. Natl. Acad. Sci., 104 13525

2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE Suppliers

Global( 118)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58

Supplier	Advantage
Shanghai Yingrui Biopharma Co., Ltd.	60
Biochempartner	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
AFINE CHEMICALS LIMITED	58
InvivoChem	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58

2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE Spectrum

2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE(349085-38-7)¹HNMR

349085-38-7(2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE)Related Search:

Minoxidil Nifedipine 2-Aminoethoxydiphenyl borate 4'-CHLORO-3-METHOXYCINNAMANILIDE 2-Methylbutane

Dimethyl N,N-Dimethylaniline N,N-Dimethylacetamide 5,5-Dimethylhydantoin POLYGODIAL

SB-705498 2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE

1of3

2-(1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL)-N-(4-ISOPROPYLPHENYL)ACETAMIDE HC 030031 2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)-N-(4-isopropylphenyl)acetamide 1,2,3,6-Tetrahydro-1,3-diMethyl-N-[4-(1-Methylethyl)phenyl]-2,6-dioxo-7H-purine-7-acetaMide 7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-N-[4-(1-methylethyl)phenyl]-2,6-dioxo- HC-030031;HC 030031;HC030031 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(4-propan-2-ylphenyl)acetamide HC 030031 1G TrpA1 Antagonist, HC-030031 TOSLAB 829227 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6 -tetrahydro-purin-7-yl)-N-isoprop yl-phenyl)-acetamide TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem HC030031; HC 030031 CS-828 HC-030031 (TOSLAB-829227) 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurin-7-yl)aceta... 349085-38-7 Intermediates & Fine Chemicals Pharmaceuticals Inhibitors Amines Aromatics Heterocycles