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2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Structure
2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl structure
CAS No.
213697-53-1
Chemical Name:
2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl
Synonyms
DAVEPHOS;2-(N,N-Dimethylamino)-2-(dicyclohexylphosphino)biphenyl;N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-diMethylaMine;Davep;2-(Dicycloh;98% DavePhos;DavePhos 97%;phosphino-2'-(N,N-dimethyL;2-Dicyclohexylphosphino-2'-(N,;2-DICYCLOHEXYLPHOSPHINO-2'-(N,N-DIMETHY&
CBNumber:
CB6344872
Molecular Formula:
C26H36NP
Molecular Weight:
393.54
MDL Number:
MFCD02183572
MOL File:
213697-53-1.mol
MSDS File:
SDS
Last updated:2023-12-13 16:54:32
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2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Properties

Melting point 121-124 °C(lit.)
Boiling point 539.6±43.0 °C(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka 5.04±0.18(Predicted)
form crystal
color white
Water Solubility Insoluble
Sensitive Air Sensitive
InChIKey ZEMZPXWZVTUONV-UHFFFAOYSA-N
CAS DataBase Reference 213697-53-1(CAS DataBase Reference)
FDA UNII 9877ONU78F

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P305+P351+P338
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22
Safety Statements  26-36/37/39
WGK Germany  3
TSCA  No
HazardClass  AIR SENSITIVE
HS Code  29310099
NFPA 704
0
2 0

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 638021 DavePhos 97% 213697-53-1 1g $31.88 2024-03-01 Buy
Sigma-Aldrich 638021 DavePhos 97% 213697-53-1 5g $137 2024-03-01 Buy
TCI Chemical D3389 2-(Dicyclohexylphosphino)-2'-(dimethylamino)biphenyl >98.0%(GC)(T) 213697-53-1 1g $138 2024-03-01 Buy
TCI Chemical D3389 2-(Dicyclohexylphosphino)-2'-(dimethylamino)biphenyl >98.0%(GC)(T) 213697-53-1 5g $415 2024-03-01 Buy
Strem Chemicals 15-1145 2-(Dicyclohexylphosphino)-2'-(N,N-dimethylamino))-1,1'-biphenyl, 98% DavePhos 213697-53-1 500mg $38 2024-03-01 Buy
Product number Packaging Price Buy
638021 1g $31.88 Buy
638021 5g $137 Buy
D3389 1g $138 Buy
D3389 5g $415 Buy
15-1145 500mg $38 Buy

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Chemical Properties,Uses,Production

Reaction

  1. Ligand used in the Pd-catalyzed Suzuki coupling and animation of unactivated aryl chlorides. The reactions generally occur at room temperature and give high yields of product.
  2. Ligand used in Pd-catalyzed C-N bond formation. A general synthesis of N6-aryl-2'deoxyadenosine analogues.
  3. Ligand used in Pd-catalyzed N-arylation of indoles.
  4. Ligand used in Pd-catalyzed synthesis of aryl-tert-butyl ethers.
  5. Effective ligand in the Pd-catalyzed arylation of ester enolates.
  6. Ligand employed in arylation of ketone enolates using ortho-halo nitrobenezenes.
  7. Ligand employed in the amination of aryl nonaflates using Pd catalysts.
  8. Ligand used for cascade alkenyl amination/Heck reaction for the synthesis of indoles.
  9. Ligand used in Pd-catalyzed Kumada-Corriu cross coupling at low temperatures.
  10. Ligand used in Rh-catalyzed intramolecular hydroamination of unactivated terminal and internal alkenes with primary and secondary amines.
  11. Ligand used in Au-catalyzed cycloisomerization of allenes.
Reactions of 213697-53-1_1
Reactions of 213697-53-1_2

Description

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl is a potent inhibitor of the enzyme bromodomain. Bromodomain has been implicated in cancer and other diseases. It binds to the bromodomain in a covalent manner, blocking the ATP site and inhibiting bromodomain function. This inhibition has been shown to be selective for bromodomains over other domains.

Chemical Properties

white to light yellow crystals or

Uses

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl can act as ligand used in the palladium-catalyzed Suzuki coupling and amination of unactivated aryl chlorides.

Uses

Effective ligand in the Pd-catalyzed arylation of ester enolates

Uses

suzuki reaction

Application

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenylacts as a growth regulator by binding to Toll-like receptor 4 (TLR4), which is important in cytokine signaling. It also inhibits allyl carbonate production and cross coupling reactions between aryl chlorides and nitrogen atoms or amines. It has an inhibitory effect on depression, but this effect is not related to its inhibitory effect on bromodomains.

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl synthesis

931-51-1
213697-53-1
Synthesis of 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl from CYCLOHEXYLMAGNESIUM CHLORIDE

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Preparation Products And Raw materials

Raw materials

Bromocyclohexane Ammonium hydroxide 2-Bromochlorobenzene 2-Bromoaniline Cyclohexane
Chlorocyclohexane Diethylamine 5-Bromo-m-xylene Phosphorus trichloride 4-Bromotoluene
1,2-Dibromoethane Tetrahydrofuran Diethyl ether Ethyl acetate Copper(I) chloride
Dichloromethane 2-Chloroaniline Magnesium Iodomethane Dimethyl sulfate

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Preparation Products

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Suppliers

Global( 345)Suppliers
Supplier Tel Email Country ProdList Advantage
XINXIANG RUNYU MATERIAL CO., LTD.
+86-13592593621; +8613592593621 sales@runvmat.com China 378 58
Shanghai UCHEM Inc. 		+862156762820 +86-13564624040 sales@myuchem.com China 6711 58
Springchem New Material Technology Co.,Limited 		+86-021-62885108 +8613917661608 info@spring-chem.com China 2068 57
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15371 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9352 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
AB PharmaTech,LLC 		323-480-4688 United States 989 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Supplier Advantage
XINXIANG RUNYU MATERIAL CO., LTD.
58
Shanghai UCHEM Inc. 		58
Springchem New Material Technology Co.,Limited 		57
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
AB PharmaTech,LLC 		55
career henan chemical co 		58

View Lastest Price from 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl pictures 2024-02-23 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl
213697-53-1
 US $39.00-422.00 / g 5g 0.98 25kg Shanghai UCHEM Inc.
2-(Dicyclohexylphosphino)-2'-(N,N-diMethylaMino)biphenyl pictures 2023-07-27 2-(Dicyclohexylphosphino)-2'-(N,N-diMethylaMino)biphenyl
213697-53-1
 US $0.00-0.00 / KG 1KG 0.98 500kg XINXIANG RUNYU MATERIAL CO., LTD.
2-Dicyclohexylphosphino-2'-(n,n-dimethylamino)biphenyl pictures 2022-01-27 2-Dicyclohexylphosphino-2'-(n,n-dimethylamino)biphenyl
213697-53-1
 US $0.00 / KG 1KG 97.3% 100 tons Honest Joy Holdings Limited

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Spectrum

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl(213697-53-1)1HNMR2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl(213697-53-1)31PNMR2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl(213697-53-1)FT-IR

213697-53-1(2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl)Related Search:

N,N-Dimethylbenzylamine Biphenyl 1,3-Bis(aminomethyl)benzene Dimethylamine 2-(Dicyclohexylphosphino)biphenyl
Dimethylamine hydrochloride 3-Dimethylaminopropylamine Minocycline 2-(Dicyclohexylphosphino)-2'-methylbiphenyl 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
DICYCLOHEXYLPHOSPHINE CYCLOHEXYLPHOSPHINE DIBUTYLPHENYLPHOSPHINE DI-N-PENTYLPHENYLPHOSPHINE Dicyclohexylphenylphosphine
2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl m-xylenediamine

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2-DICYCLOHEXYLPHOSPHINO-2'-(N,N-DIMETHY& 2-(DICYCLOHEXYLPHOSPHINO)-2'-(DIMETHYLAMINO)BIPHENYL 2-DICYCLOHEXYLPHOSPHINO-2'-(N,N-DIMETHYLAMINO)BIPHENYL 2-Dicyclohexylphosphino-2'-(N, 2-(Dicyclohexylphosphino)-2'-(N,N-dimethylamino)biphenyl,98%DavePhos 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)- [1,1''-BIPHENYL]-2-AMINE, 2''-(DICYCLOHEXYLPHOSPHINO)-N,N-DIMETHYL- 2-Dicgclohexylphosphino-2’-(N,N-dimethylamino)biphenyl Davep 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl,97% 2-Dicyclohexylphosphino-2-(N,N-dimethylamino)biphenyl,98% 2-Dicyclohexylphosphino-2-(N,N-dimethylamino)biphenyl（Davephos） 2-Dicyclohexylphosphino-2-(N,N-dimethylamino)biph 2-[2-(dicyclohexylphosphanyl)phenyl]-N,N-diMethylaniline Davephos (2-(Di-tert-butylphosphino)biphenyl) 98% DavePhos 2-DicyclohexylphosphiNA-2'-(N,N-diMethylaMiNA)biphenyl 2'-(dicyclohexylphosphino)-N,N-diMethyl-[1,1'-biphenyl]-2-aMine 2-(Dicyclohexylphosphanyl)-2'-(dimethylamino)biphenyl 2'-(Dicyclohexylphosphanyl)-N,N-dimethylbiphenyl-2-amine, Dicyclohexyl[2'-(dimethylamino)biphenyl-2-yl]phosphine DavePhos 97% 2-(N,N-Dimethylamino)-2-(dicyclohexylphosphino)biphenyl, DavePhos 2-(Dicyclohexylphosphino)-2'-(N,N-dimethylamino))-1,1'-biphenyl, 98% 2-Dimethylamino-2'-dicyclohexylphosphinobiphenyl 2-(Dicyclohexylphosphino)-2'-(N,N-dimethylamino))-1,1'-biphenyl, 98% DavePhos 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)bipheny 2-(Dicycloh 2-(Dicyclohexylphosphino)-2'-(N,N-dimethylamino)biphenyl,98%DavePh phosphino-2'-(N,N-dimethyL 2-(Dicyclohexylphosphino)-2'-(dimethylamino)biphenyl> 2-(Dicyclohexylphosphino)-2'-(N,N-dimethylamino))-1,1'-biphenyl,98% DavePhos 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl 2-Dicyclohexylphosphino-2-(N,N-dimethyiamino)-1,1'-biphenyl 213697-53-1 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl‘ 213697-53-1 DAVEPHOS 2-(N,N-Dimethylamino)-2-(dicyclohexylphosphino)biphenyl N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-diMethylaMine (2-Dimethylamino-1,1'-biphenyl-2-yl)dicyclohexylphosphine 2-Dicyclohexyphenyl-2 '- (N, N-dimethylamine) - biphenyl 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl 213697-53-1 CH32NC6H4C6H4PC6H112 C26H36NP Catalysis and Inorganic Chemistry Buchwald Ligands Phosphorus Compounds Phosphine Ligands Buchwald Ligands&Precatalysts Achiral Phosphine Aryl Phosphine Buchwald Ligands Series Phosphines Biphenyl & Diphenyl ether Phosphine Ligands Synthetic Organic Chemistry