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Ethyl trifluoroacetate

Ethyl trifluoroacetate structure

CAS No.: 383-63-1

Chemical Name:: Ethyl trifluoroacetate

Synonyms: ETHYL 2,2,2-TRIFLUOROACETATE;ETFA;TFAET;TRIFLUOROACETIC ACID ETHYL ESTER;CF3COOC2H5;RARECHEM AL BI 0416;2,2,2-Trifluoroacetic acid ethyl ester;cb1020;fd06h11;wu:fd06h11

CBNumber:: CB6349488

Molecular Formula:: C4H5F3O2

Molecular Weight:: 142.08

MDL Number:: MFCD00000419

MOL File:: 383-63-1.mol

MSDS File:: SDS

Last updated:2023-11-16 09:58:58

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Ethyl trifluoroacetate Properties

Melting point	-78 °C
Boiling point	60-62 °C(lit.)
Density	1.194 g/mL at 25 °C(lit.)
vapor pressure	18.5kPa at 20℃
refractive index	n20/D 1.307(lit.)
Flash point	30 °F
storage temp.	2-8°C
solubility	4g/l
pka	0.43[at 20 ℃]
form	Liquid
Specific Gravity	1.194
color	Clear
PH	4 (4g/l, H2O, 20℃)
Water Solubility	HYDROLYSIS
Sensitive	Moisture Sensitive
BRN	1761411
Stability	Hygroscopic, Moisture Sensitive, Volatile
InChIKey	STSCVKRWJPWALQ-UHFFFAOYSA-N
LogP	0.79-1.032 at 25℃
CAS DataBase Reference	383-63-1(CAS DataBase Reference)
FDA UNII	A6TZK6X11X
NIST Chemistry Reference	Acetic acid, trifluoro-, ethyl ester(383-63-1)
EPA Substance Registry System	Ethyl trifluoroacetate (383-63-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05,GHS07

Signal word

Danger

Hazard statements

H225-H302-H315-H318-H335

Precautionary statements

P210-P261-P280-P305+P351+P338

Hazard Codes

F,Xn,C

Risk Statements

11-22-37/38-41-34

Safety Statements

9-16-26-36/39-45-36/37/39

RIDADR

UN 1993 3/PG 2

WGK Germany

Hazard Note

Flammable/Corrosive

TSCA

HazardClass

PackingGroup

HS Code

29159080

NFPA 704

	3
2		0

Ethyl trifluoroacetate price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	E50000	Ethyl trifluoroacetate 99%	383-63-1	25g	$33.2	2024-03-01	Buy
Sigma-Aldrich	E50000	Ethyl trifluoroacetate 99%	383-63-1	100g	$110	2024-03-01	Buy
TCI Chemical	T0432	Ethyl Trifluoroacetate >99.0%(GC)	383-63-1	25g	$35	2024-03-01	Buy
TCI Chemical	T0432	Ethyl Trifluoroacetate >99.0%(GC)	383-63-1	100g	$98	2024-03-01	Buy
Alfa Aesar	A11520	Ethyl trifluoroacetate, 99%	383-63-1	50g	$51.9	2024-03-01	Buy

Product number	Packaging	Price	Buy
E50000	25g	$33.2	Buy
E50000	100g	$110	Buy
T0432	25g	$35	Buy
T0432	100g	$98	Buy
A11520	50g	$51.9	Buy

Ethyl trifluoroacetate Chemical Properties,Uses,Production

Chemical Properties

Colorless to yellow liquid

Uses

Ethyl Trifluoroacetate is an intermediate used in the synthesis of various pharmaceutically active molecules and agricultural products. Ethyl Trifluoroacetate is also useful for the preparation of tri fluoroacylated compounds.

Uses

Widely used in the synthetic process of medicine, pesticides and organic intermediate.

Uses

Ethyl trifluoroacetate is used as an intermediate in organic synthesis to prepare organic fluorine compounds like 3-ethyl-1-methylimidazolium trifluoroacetate (EMITA). It is involved in the syntheses of various pharmaceutically active molecules and agricultural products. It is also useful for the preparation of tri fluoroacylated compounds.

Preparation

Trifluoroacetic acid and ethanol were used as starting materials with strong-acid cation exchange resin as catalysts at 40 ~ 50 she℃. Add ethanol drop and temperature rising reflux divides the mixture of water and ethanol. After that, collect the mix of thick product ethanol and Ethyl trifluoroacetate. The crude product collected is added a small amount of water, and layering can obtain a content of more than 99.5%. The qualified product Ethyl trifluoroacetate, whose moisture is less than 0.1%, yields more than 95%.

Definition

ChEBI: TRIFLUOROACETIC ACID ETHYL ESTER is an organohalogen compound. It is functionally related to a carboxylic acid.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 3527, 1950 DOI: 10.1021/ja01164a056

Flammability and Explosibility

Highly flammable

Purification Methods

Fractionate it through a long Vigreux column (p 11). IR has max at 1800 (CO2) and 1000 (OCO) cm-1 [Fuson et al. J Chem Phys 20 1627 1952, Bergman J Org Chem 23 476 1958]. [Beilstein 2 IV 463.]

Ethyl trifluoroacetate synthesis

Synthesis of Ethyl trifluoroacetate from Trifluoroacetyl chloride and Ethanol

Ethyl trifluoroacetate Preparation Products And Raw materials

Raw materials

Trifluoroacetic acid Ethyl trifluoromethanesulfonate

Preparation Products

2-[1-METHYL-5-(TRIFLUOROMETHYL)PYRAZOL-3-YL]-THIOPHENE-5-CARBOXALDEHYDE EUROPIUM D-3-TRIFLUOROACETYLCAMPHORATE 8-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE-4-CARBONITRILE 3-TRIFLUOROACETYL-D-CAMPHOR 6,7-DIMETHOXY-3-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE

2-AMINO-4-PHENYL-6-(TRIFLUOROMETHYL)PYRIMIDINE 4,4,4-Trifluoro-1-phenyl-1,3-butanedione 2-AMINO-6-T-BUTYL-4-(TRIFLUOROMETHYL)PYRIMIDINE METHYL5,5,5-TRIFLUORO-4-OXOPENTANOATE 1,1,1-Trifluoro-2-hexanone

Efavirenz 4-(TRIFLUOROMETHYL)-ALPHA,ALPHA,ALPHA-TRIFLUOROACETOPHENONE HEXAFLUOROACETYLACETONE BENZALDEHYDE DIETHYL ACETAL 1,1,1-TRIFLUORO-5,5-DIMETHYL-2,4-HEXANEDIONE

2-(TRIFLUOROMETHYL)PYRIMIDINE-4,6-DIOL 3'-METHOXY-2,2,2-TRIFLUOROACETOPHENONE 3-PHENYL-1,1,1-TRIFLUOROPROPAN-2-ONE 1-(2-AMINO-5-CHLOROPHENYL)-2,2,2-TRIFLUOROETHANONE

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Ethyl trifluoroacetate Suppliers

Global( 545)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou Qiwei Pharmatech Co.,Ltd	13282840061	mw@qwpharmatech.com	China	109	58
Shandong Dexiang International Trade Co., Ltd	15662695772;+8615662691337	sales006@dexiangchemical.com	China	998	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +86-18949832763	info@tnjchem.com	China	2989	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
Kingfirst chemical (nanjing) co.,ltd	86-25-84522992	marketing@kingfirstchem.com	CHINA	95	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58

Supplier	Advantage
Hangzhou Qiwei Pharmatech Co.,Ltd	58
Shandong Dexiang International Trade Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
Hefei TNJ Chemical Industry Co.,Ltd.	55
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Kingfirst chemical (nanjing) co.,ltd	58
Hubei Jusheng Technology Co.,Ltd.	58

View Lastest Price from Ethyl trifluoroacetate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-25	Ethyl trifluoroacetate 383-63-1	US $0.00 / KG	1KG	99%	200mt	Jinan Finer Chemical Co., Ltd
2023-03-27	Ethyl trifluoroacetate 383-63-1	US $5.00 / KG	1KG	0.99	5t	XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
2023-03-06	Ethyl Trifluoroacetate 383-63-1	US $10.70 / Kg/Drum	10g	99%	10000kg	Hebei Guanlang Biotechnology Co,.LTD

Ethyl trifluoroacetate
383-63-1
US $0.00 / KG
99%
Jinan Finer Chemical Co., Ltd

Ethyl trifluoroacetate
383-63-1
US $5.00 / KG
0.99
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD

Ethyl Trifluoroacetate
383-63-1
US $10.70 / Kg/Drum
99%
Hebei Guanlang Biotechnology Co,.LTD

Ethyl trifluoroacetate Spectrum

Ethyl trifluoroacetate(383-63-1)MS Ethyl trifluoroacetate(383-63-1)¹HNMR Ethyl trifluoroacetate(383-63-1)¹³CNMR Ethyl trifluoroacetate(383-63-1)IR1 Ethyl trifluoroacetate(383-63-1)Raman

383-63-1(Ethyl trifluoroacetate)Related Search:

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ETHYL TRIFLUOROACETATE TIMTEC-BB SBB008466 Threetrifluoroacetic acid ethyl ester cb1020 fd06h11 wu:fd06h11 aceticacid,trifluoro-,ethylester Ethyl ester of Trifluoroacetic acid Ethyl trifluoroethanoate ethylperfluoroacetate Trifluoressigsαureethylester trifluoro-aceticaciethylester VITAS-BB TBB000648 3,4,5-Trimethoxybenzenesulfonic Acid Sodium ETHYL TRIFLUOROACETATE 98% (GC) Ethyl trifluoroacetate,99% Ethyl trifluoroacetate 99% 2,2,2-TRIFLOUROETHYL ACETATE (TFAET) Ethyltrifluoracetat trifluoroacetatic acid ethyl ester Ethyl trifluoroacetate, 98+% Ethyl trifluoroaceta Trifluoroacetic acid ethyl Ethyl 4-trifluoroacetate Ethyl trifluoroacetate, 99% 100ML Ethyl trifluoroacetate, 99% 25ML Ethyl trifluoroacetate or Propyl ester Ethyltrifuoroacetate Ethyltrifluoroacetate(ETFA) Ethyl Trifluoroacetate > ETHYL TRIFLUOROACETATE For Synthesis RARECHEM AL BI 0416 ETHYL 2,2,2-TRIFLUOROACETATE TRIFLUOROACETIC ACID ETHYL ESTER CF3COOC2H5 TFAET ETFA 2,2,2-Trifluoroacetic acid ethyl ester Sitagliptin Impurity 76 Ethyl trifluoroacetate（TFAE） 383-63-1 CF3CO2C2H5 F3CCOOC2H5 C4H5F3O2 CF3CO2CH2CH3 Building Blocks Carbonyl Compounds C2 to C5 Organic Building Blocks Esters Fluorinated Building Blocks Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds organofluorine compounds Building Blocks C2 to C5 Carbonyl Compounds Chemical Synthesis Esters