1,9-Pyrazoloanthrone
- CAS No.
- 129-56-6
- Chemical Name:
- 1,9-Pyrazoloanthrone
- Synonyms
- SP600125;pyrazolanthrone;1PMV;JNKII;CS-548;Nsc75890;Anthra H;c.i.70300;Pyrazoxanone;SP600125 >99%
- CBNumber:
- CB6354608
- Molecular Formula:
- C14H8N2O
- Molecular Weight:
- 220.23
- MDL Number:
- MFCD00022289
- MOL File:
- 129-56-6.mol
- MSDS File:
- SDS
| Melting point | 281~282℃ |
|---|---|
| Boiling point | 361.16°C (rough estimate) |
| Density | 1.1702 (rough estimate) |
| refractive index | 1.5910 (estimate) |
| storage temp. | 2-8°C |
| solubility | H2O: insoluble |
| form | Yellowish orange solid |
| pka | 11.75±0.20(Predicted) |
| color | yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months |
| InChIKey | ACPOUJIDANTYHO-UHFFFAOYSA-N |
| CAS DataBase Reference | 129-56-6(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 1TW30Y2766 |
| EPA Substance Registry System | Anthra[1,9-cd]pyrazol-6(2H)-one (129-56-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CB4585000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29339900 | |||||||||
| Toxicity | LD50 ivn-mus: 178 mg/kg CSLNX* NX#00640 | |||||||||
| NFPA 704 |
|
1,9-Pyrazoloanthrone price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S5567 | SP600125 ≥98% (HPLC) | 129-56-6 | 10mg | $127 | 2024-03-01 | Buy |
| Sigma-Aldrich | S5567 | SP600125 ≥98% (HPLC) | 129-56-6 | 50mg | $545 | 2024-03-01 | Buy |
| Sigma-Aldrich | 420119 | JNK Inhibitor II | 129-56-6 | 5mg | $99.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | 420119 | JNK Inhibitor II | 129-56-6 | 25mg | $303 | 2024-03-01 | Buy |
| TCI Chemical | A2548 | Anthra[1,9-cd]pyrazol-6(2H)-one >98.0%(HPLC) | 129-56-6 | 25mg | $138 | 2024-03-01 | Buy |
1,9-Pyrazoloanthrone Chemical Properties,Uses,Production
Description
SP-600125 (129-56-6) is a selective inhibitor of c-Jun N-terminal kinase (JNK). Reversibly inhibits JNK1,2 and 3 (IC50‘s range from 40-90 nM). >300-fold selectivity for JNK as compared to related MAP kinases. Anti-inflammatory activity. SP-600125 inhibits expression of presenilin-1 and Notch signaling in mouse brain. Cell permeable and active in vivo.
Uses
SP 600125 is a Jun N-terminal kinase (JNK) inhibitor.
Uses
A broad-spectrum serine/threonine kinase inhibitor of JNK with an IC50 range from 40 to 90 nM.
Uses
C2C12 myoblasts were treated with SP600125 to test the stimulation of myogenesis.11 It was used to treat HepG2 cells to test the effects on oxysterol-induced necrosis.12
Definition
ChEBI: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
General Description
A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription.
Biological Activity
Selective inhibitor of c-Jun N-terminal kinase (JNK). Competitively and reversibly inhibits JNK1, 2 and 3 (IC 50 = 40-90 nM) with negligible activity at ERK2, p38 β and a range of enzymes (IC 50 > 10 μ M). Active in vivo . Shown to have reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis. Also available as part of the MAPK Inhibitor Tocriset™ .
Biochem/physiol Actions
SP600125 is an anthrapyrazolone inhibitor of JNK that competes with ATP to inhibit the phosphorylation of c-Jun. It prevents the activation of inflammatory genes such as COX-2, IL-2 IFN-γ and TNF-α.8,9 It prevents the activation of JNK after brain ischemia and may be effective in treatment of ischemic stroke.10
Safety Profile
Poison by intravenous route.When heated to decomposition it emits toxic fumes ofNOx.
Synthesis
1,9-Pyrazolanthrone is prepared by diazotization of 1-aminoanthraquinone, reaction of the diazonium salt with sodium hydrogen sulfite, and cyclization of the resulting hydrazinosulfonic acid .
storage
-20°C (desiccate)
References
1)Bennett et al. (2001), SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase; Proc. Natl. Acad. Sci. USA., 98 13681 2) Rahman et al. (2012), Intraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis; Brain Res., 1448 117
1,9-Pyrazoloanthrone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81148696 +8615536356810 | 1047@dideu.com | China | 3679 | 58 |
View Lastest Price from 1,9-Pyrazoloanthrone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-08-04 | 1,9-Pyrazoloanthrone
129-56-6
|
US $0.00-0.00 / kg | 1kg | 0.99 | 500000kg | Hebei Yibangte Import and Export Co. , Ltd. | |
 |
2023-07-25 | SP 600125
129-56-6
|
US $50.00 / kg | 1kg | 99.9% | 10000MT | Henan Bao Enluo International TradeCo.，LTD | |
 |
2023-06-20 | 1,9-Pyrazoloanthrone
129-56-6
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- 1,9-Pyrazoloanthrone
129-56-6
- US $0.00-0.00 / kg
- 0.99
- Hebei Yibangte Import and Export Co. , Ltd.
-
- SP 600125
129-56-6
- US $50.00 / kg
- 99.9%
- Henan Bao Enluo International TradeCo.，LTD
-
- 1,9-Pyrazoloanthrone
129-56-6
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd