(-)-SINOACUTINE
- CAS No.
- Chemical Name:
- (-)-SINOACUTINE
- Synonyms
- (-)-SINOACUTINE
- CBNumber:
- CB6355665
- Molecular Formula:
- C19H21NO4
- Molecular Weight:
- 327.37
- MDL Number:
- MFCD00238685
- MOL File:
- Mol file
(-)-SINOACUTINE Chemical Properties,Uses,Production
Description
A morphine type alkaloid isolated from Sinomenium acutum Rehd. and Wils, the base is laevorotatory with[α]16D - 112° (EtOH) or - 81.60 (CHCI3). It yields a series of crystalline salts and derivatives including the perchlorate, m.p. 117°C; tartrate, m.p. 203-4°C; picrate, m.p. 222°C (dec.); oxime, m.p. 223°C and the methiodide, m.p. 216°C. The alkaloid also forms the O-acetate, m.p. 175°C; [α]D - 125° (EtOH) with AC20 in pyridine, indicative of a phenolic hydroxyl group. On hydrogenation it forms tetrahydrosinoacutinol, C19H2704N, m.p. 216°C. The O-methyl ether yields a crystalline methiodide which contains Me2CO when obtained from this solvent, m.p. 163-6°C. According to Johns and his co-workers, the alkaloid is also present in Cassytha pubescens R. Br.
Uses
Sinoacutine is an isoquinoline alkaloid used as a prolyl oligopeptidase inhibitor.
References
Chu, Lo, Chou., Acta Chirn. Sinica., 30,265 (1964)
Barton, Korby, Kirby., Chern. Cornrnun., 52 (1965)
Chambers, Haynes, Stuart., ibid, 449 (1966)
Johns, Lamberton, Sioumis., Austral. J. Chern., 19,2331 (1966)
Circular dichroism:
Snatzke, Wollenberg.,l. Chern. Soc., C, 1681 (1966)
(-)-SINOACUTINE Preparation Products And Raw materials
Raw materials
Preparation Products
(-)-SINOACUTINE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Beijing Meida Technology Co. Ltd. | 1411179304@qq.com | CHINA | 321 | 58 | |
Shanghai Lianmai Biological Engineering Co., Ltd. | -- | shlmai@163.com | CHINA | 6700 | 58 |
Beijing Fubo Biotechnology Co., Ltd. | -- | info@f-biology.com | CHINA | 6039 | 58 |
Wuhan Boot Biotechnology Co., Ltd. | -- | CHINA | 6829 | 58 | |
Wuhan Qiongge Biological Technology Co., Ltd. | -- | 1214415300@qq.com | CHINA | 5376 | 58 |
Suzhou Ruinuode Biotechnology Co., Ltd. | -- | 2090855807@qq.com | CHINA | 6063 | 58 |
Shanghai Wowu Biological Technology Co., Ltd. | -- | shhebio@126.com | CHINA | 6137 | 58 |
Jiangxi Jianglan Pure Biological Reagent Co., Ltd. | -- | 3245176082@qq.com | CHINA | 6136 | 58 |
Shanghai Zeye Biotechnology Co., Ltd. | -- | shzeysw@163.com | CHINA | 6550 | 58 |
Shanghai Machine Pure Industrial Co., Ltd. | -- | 3245176082@qq.com | CHINA | 6800 | 58 |