ChemicalBook >> CAS DataBase List >>Ethyl 2-(triphenylphosphoranylidene)propionate
Ethyl 2-(triphenylphosphoranylidene)propionate
- CAS No.
- 5717-37-3
- Chemical Name:
- Ethyl 2-(triphenylphosphoranylidene)propionate
- Synonyms
- (CARBETHOXYETHYLIDENE)TRIPHENYLPHOSPHORANE;CEETPP;CEY;AURORA KA-4803;idene)triphenyL;(CarbethoxyethyL;LABOTEST-BB LT00454031;Sacubitril Impurity 81;Sacubitril/Valsartan intermediates;1-Ethoxycarbonyl-ethyliden-phosphoran
- CBNumber:
- CB6381055
- Molecular Formula:
- C23H23O2P
- Molecular Weight:
- 362.4
- MDL Number:
- MFCD00009160
- MOL File:
- 5717-37-3.mol
- MSDS File:
- SDS
Last updated:2023-05-15 10:43:14
| Melting point | 158-162 °C (lit.) |
|---|---|
| Boiling point | 497.2±28.0 °C(Predicted) |
| Density | 1.14±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Crystalline Powder |
| color | Yellow |
| Water Solubility | Soluble in water. |
| Sensitive | Air Sensitive |
| BRN | 757112 |
| InChIKey | KZENFXVDPUMQOE-UHFFFAOYSA-N |
| CAS DataBase Reference | 5717-37-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Propanoic acid, 2-(triphenylphosphoranylidene)-, ethyl ester(5717-37-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P260-P280-P312 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 36/37/38-25 | |||||||||
| Safety Statements | 45-37/39-26 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29319090 | |||||||||
| NFPA 704 |
|
Ethyl 2-(triphenylphosphoranylidene)propionate price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 377708 | (Carbethoxyethylidene)triphenylphosphorane 94% | 5717-37-3 | 5g | $62.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | 377708 | (Carbethoxyethylidene)triphenylphosphorane 94% | 5717-37-3 | 25g | $217 | 2024-03-01 | Buy |
| TCI Chemical | C1641 | Ethyl 2-(Triphenylphosphoranylidene)propionate >97.0%(HPLC) | 5717-37-3 | 5g | $84 | 2024-03-01 | Buy |
| Alfa Aesar | A15619 | (1-Ethoxycarbonylethylidene)triphenylphosphorane, 97% | 5717-37-3 | 10g | $77.65 | 2024-03-01 | Buy |
| Alfa Aesar | A15619 | (1-Ethoxycarbonylethylidene)triphenylphosphorane, 97% | 5717-37-3 | 25g | $168.65 | 2024-03-01 | Buy |
Ethyl 2-(triphenylphosphoranylidene)propionate Chemical Properties,Uses,Production
Chemical Properties
yellow crystalline powder
Uses
(1-Ethoxycarbonylethylidene)triphenylphosphorane is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals. It?s also a Horner-Wadsworth-Emmons reagent. It can be used for olefination. It can also be utilized for the synthesis of more complex compounds, such as (29S,37S)-isomer of malevamide E, a potent ion-channel inhibitor.
Synthesis
Ethyl 2-(triphenylphosphoranylidene)propionate was prepared this reagent from ethyl 2-bromopropanoate and triphenylphosphine.A 500-mL, one-necked, round-bottomed flask equipped with an egg-shaped magnetic stirring bar is charged with triphenylphosphine (52.46 g, 200.0 mmol), ethyl acetate (130 mL), and ethyl 2-bromopropanoate (26.03 mL, 200.0 mmol). A reflux condenser is attached to the flask and the solution is heated under reflux (oil bath temperature: 75-80 °C) under argon for 24 h. The resulting white precipitate is collected through suction filtration on a Büchner funnel and washed with ethyl acetate (100 mL). The salt is dissolved in dichloromethane (500 mL) and the solution is transferred to a 1-L separation funnel. Aqueous sodium hydroxide solution (2 M, 200 mL) is added and, after vigorously shaking, the organic and aqueous layers are separated. The aqueous phase is extracted with dichloromethane (100 mL). The combined organic phases are washed with brine, dried over anhydrous Na2SO4, filtered, and concentrated at 30 °C under rotary evaporation (20-25 mmHg); drying under vacuum (0.1-0.2 mmHg) affords 54.51 g (75.2%) of ethyl 2-(triphenylphosphoranylidene)propionate as a light-yellow solid, mp 156-158 °C.
Synthesis of Ethyl 2-(triphenylphosphoranylidene)propionate from Triphenylphosphine and ethyl (±)-2-bromopropionate
Ethyl 2-(triphenylphosphoranylidene)propionate Preparation Products And Raw materials
Global( 477)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangxi Huihe Chemical Co., Ltd. | +86-19189228086 +8618858568638 | wuzhouding@huihecrop.com | China | 886 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7845 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 811 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
View Lastest Price from Ethyl 2-(triphenylphosphoranylidene)propionate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-01-14 | (Carbethoxyethylidene)triphenylphosphorane
5717-37-3
|
US $5.00-0.50 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-02-24 | Ethyl 2-(triphenylphosphoranylidene)propionate
5717-37-3
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2023-01-31 | Ethyl 2-(triphenylphosphoranylidene)propionate
5717-37-3
|
US $100.00 / kg | 1kg | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- (Carbethoxyethylidene)triphenylphosphorane
5717-37-3
- US $5.00-0.50 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Ethyl 2-(triphenylphosphoranylidene)propionate
5717-37-3
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Ethyl 2-(triphenylphosphoranylidene)propionate
5717-37-3
- US $100.00 / kg
- 99%
- Hebei Mojin Biotechnology Co., Ltd
Ethyl 2-(triphenylphosphoranylidene)propionate Spectrum
Ethyl 2-(triphenylphosphoranylidene)propionate(5717-37-3)MSEthyl 2-(triphenylphosphoranylidene)propionate(5717-37-3)1HNMREthyl 2-(triphenylphosphoranylidene)propionate(5717-37-3)IR1Ethyl 2-(triphenylphosphoranylidene)propionate(5717-37-3)IR2Ethyl 2-(triphenylphosphoranylidene)propionate(5717-37-3)Raman
5717-37-3(Ethyl 2-(triphenylphosphoranylidene)propionate)Related Search:
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Ethyl 2-(triphenylphosphoranylidene)propanoate
TIANFU-CHEM --Ethyl 2-(triphenylphosphoranylidene)propionate
(CARBETHOXYETHYLIDENE)TRIPHENYLPHOSPHORANE
CEETPP
Ethoxy formyl ethyl triphenyl phosphine
Carbethoxyethylidene triphenylphosphorane(CEETPP)
Ethoxyformyl ethylidene triphenylphosphine
1-CARBETHOXYETHYLIDENE TRIPHENYL PHOSPHR
ETHYL-2-(TRIPHENYLPHOSPHORANYLIEDINE)PROPANOATE
Sacubitril Impurity 81
ETHYL-2- (TRIPHENYLPHOSPHORANYLIDENE)PROPIONATE
1-Carbethoxyethylidene triphenylphosphorane
1-(Ethoxycarbonyl)ethylidenetriphenylphosphorane
Sacubitril/Valsartan intermediates
Ethyl 2-(TriPhenylPhosphoranylidene) Propionat Commercial
5717-37-3
CH3CPC6H53CO2C2H5
C23H23O2P
C-C Bond Formation
Olefination