5-Bromouracil
- CAS No.
- 51-20-7
- Chemical Name:
- 5-Bromouracil
- Synonyms
- 5-bromopyrimidine-2,4(1H,3H)-dione;5-BROMOPYRIMIDINE-2,4-DIOL;5-BROMO-1H-PYRIMIDINE-2,4-DIONE;5-Bromo-1,2,3,4-tetrahydropyrimidine-2,4-dione;5-BrUra;BROMOURACIL;5-Bromuracil;5-BROMOURACIL;5-bromo-uraci;BROMOURACIL, 5-
- CBNumber:
- CB6388195
- Molecular Formula:
- C4H3BrN2O2
- Molecular Weight:
- 190.98
- MDL Number:
- MFCD00006017
- MOL File:
- 51-20-7.mol
- MSDS File:
- SDS
| Melting point | >300 °C (lit.) |
|---|---|
| Density | 1.8710 (rough estimate) |
| refractive index | 1.6200 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | <1g/l |
| pka | 6.77±0.10(Predicted) |
| form | Solid |
| color | White |
| Water Solubility | SOLUBLE IN COLD WATER |
| Merck | 14,1445 |
| BRN | 127176 |
| InChIKey | LQLQRFGHAALLLE-UHFFFAOYSA-N |
| CAS DataBase Reference | 51-20-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 4HK400G5UO |
| NIST Chemistry Reference | 5-Bromouracil(51-20-7) |
| EPA Substance Registry System | 5-Bromouracil (51-20-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H341 | |||||||||
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-46 | |||||||||
| Safety Statements | 36/37-53-45-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YQ9060000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29335995 | |||||||||
| NFPA 704 |
|
5-Bromouracil price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 852473 | 5-Bromouracil 98% | 51-20-7 | 5g | $45.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | 852473 | 5-Bromouracil 98% | 51-20-7 | 25g | $85.1 | 2024-03-01 | Buy |
| TCI Chemical | B0665 | 5-Bromouracil >98.0%(T) | 51-20-7 | 25g | $120 | 2024-03-01 | Buy |
| Alfa Aesar | A14799 | 5-Bromouracil, 98+% | 51-20-7 | 5g | $19.65 | 2024-03-01 | Buy |
| Alfa Aesar | A14799 | 5-Bromouracil, 98+% | 51-20-7 | 25g | $56.65 | 2024-03-01 | Buy |
5-Bromouracil Chemical Properties,Uses,Production
Description
5-bromouracil (5-BU) is a uracil derivative, and its 5' position of the pyrimidine ring is halogenated. If 5-BU is incorporated into DNA in place of thymine, the tautomeric shift will occur, and the 5-BU will base pair with guanine. After the replication, an A-T to G-C transition occurs. Furthermore, the presence of 5-BU within DNA increases the sensitivity of the molecule to UV light. 5-BU is structurally similar to thymine. Therefore, it is considered a thymine analog and base-pairs normally with adenine. It is rarely present in its enol form, where its base pairs with guanine. 5-Bromouracil treats neoplasms in the form of its nucleoside, 5-bromo-2-deoxy-uridine[1-2].
Chemical Properties
Prisms from H 2 O.
Uses
A major chemical mutagen. Incorporates into DNA, altering base-pair sequencing by replacing thymine
Definition
ChEBI: A pyrimidine having keto groups at the 2- and 4-positions and a bromo group at the 5-position.
General Description
White powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
A halogenated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Hazard
Moderately toxic, alters DNA by replacing thymine.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition 5-Bromouracil emits very toxic fumes of bromide ion and NOx.
Fire Hazard
Flash point data for 5-Bromouracil are not available, but 5-Bromouracil is probably combustible.
Safety Profile
Moderately toxic by intraperitoneal route. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of Brand NOx.
References
[1] Bhagavan, N. and C. Ha. “Chapter 21 – Structure and Properties of DNA.” (2015): 381-400.
[2] Shen, Chang-Hui. “Nucleic Acid-Based Cellular Activities.” Diagnostic Molecular Biology 25 1 (2019): 27-57.
5-Bromouracil Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Jiuwu Chemical co., Ltd. | +86-0519-85121086 +8613775162768 | info@jiuwuchem.cn | China | 75 | 58 |
| Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 | sales@zhswyy.com | China | 338 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2141 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 906 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
View Lastest Price from 5-Bromouracil manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-24 | 5-Bromouracil
51-20-7
|
US $0.00-0.00 / kg | 0.10000000149011612kg | 99 | 20tons | Chongqing Zhihe Biopharmaceutical Co., Ltd. | |
 |
2024-03-16 | 5-Bromouracil
51-20-7
|
US $0.00 / KG | 100g | 98%+ | 100kg | WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD | |
 |
2022-10-18 | 5-Bromouracil
51-20-7
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 5-Bromouracil
51-20-7
- US $0.00-0.00 / kg
- 99
- Chongqing Zhihe Biopharmaceutical Co., Ltd.
-
- 5-Bromouracil
51-20-7
- US $0.00 / KG
- 98%+
- WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
-
- 5-Bromouracil
51-20-7
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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