1,1,2-Trichloroethane

1,1,2-Trichloroethane Properties

Melting point	-37 °C
Boiling point	110-115 °C (lit.)
Density	1.435 g/mL at 25 °C (lit.)
vapor pressure	30.3 at 25 °C (quoted, Mackay et al., 1982)
refractive index	n20/D 1.471(lit.)
Flash point	11 °C
storage temp.	2-8°C
solubility	Soluble in ethanol and chloroform (U.S. EPA, 1985)
form	Liquid
color	Clear colorless
Water Solubility	4 g/L (20 ºC)
Merck	14,9637
BRN	1731726
Henry's Law Constant	8.70 at 30 °C (headspace-GC, Sanz et al., 1997)
Exposure limits	Potential occupational carcinogen. NIOSH REL: TWA 10 ppm (45 mg/m³), IDLH 100 ppm; OSHA PEL: TWA 10 ppm (adopted).
Dielectric constant	7.2800000000000002
Stability	Stable.
EPA Primary Drinking Water Standard	MCL:0.005,MCLG:0.003
LogP	2.05-2.49 at 20℃ and pH7
Indirect Additives used in Food Contact Substances	1,1,2-TRICHLOROETHANE
FDA 21 CFR	175.105
CAS DataBase Reference	79-00-5(CAS DataBase Reference)
EWG's Food Scores	5
FDA UNII	28E9ERN9WU
Proposition 65 List	Vinyl trichloride (1,1,2-Trichloroethane)
IARC	3 (Vol. 52, 71) 1999
NIST Chemistry Reference	Ethane, 1,1,2-trichloro-(79-00-5)
EPA Substance Registry System	1,1,2-Trichloroethane (79-00-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H302+H312-H331-H351-H412

Precautionary statements

P201-P273-P280-P302+P352+P312-P304+P340+P311-P308+P313

Hazard Codes

Xn,Xi,T,F

Risk Statements

20/21/22-40-66-39/23/24/25-23/24/25-11-23-21/22

Safety Statements

9-36/37-46-45-16-7

RIDADR

3082

WGK Germany

3

RTECS

KJ3150000

Hazard Note

Irritant

HazardClass

6.1(b)

PackingGroup

III

HS Code

29031990

Toxicity

Acute oral LD50 for mice 378 mg/kg, rats 580 mg/kg (quoted, RTECS, 1985).

IDLA

100 ppm

NFPA 704

	1
2		0

1,1,2-Trichloroethane price More Price(17)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	466212	1,1,2-Trichloroethane contains ≤3% 2-propanol as stabilizer, 97%	79-00-5	25ml	$119	2024-03-01	Buy
Sigma-Aldrich	466212	1,1,2-Trichloroethane contains ≤3% 2-propanol as stabilizer, 97%	79-00-5	1l	$264	2024-03-01	Buy
Sigma-Aldrich	40013	1,1,2-Trichloroethane solution certified reference material, 5000?μg/mL in methanol	79-00-5	1ML	$61.6	2024-03-01	Buy
Sigma-Aldrich	46262	1,1,2-Trichloroethane analytical standard	79-00-5	5ML	$55.9	2022-05-15	Buy
TCI Chemical	T0381	1,1,2-Trichloroethane >98.0%(GC)	79-00-5	25g	$27	2024-03-01	Buy

Product number	Packaging	Price	Buy
466212	25ml	$119	Buy
466212	1l	$264	Buy
40013	1ML	$61.6	Buy
46262	5ML	$55.9	Buy
T0381	25g	$27	Buy

1,1,2-Trichloroethane Chemical Properties,Uses,Production

Chemical Properties

Clear, colorless liquid; characteristic sweet odor. Miscible with alcohols, ethers, esters, and ketones; insoluble in water. Nonflammable.

Chemical Properties

1,1,2-Trichloroethane is a colorless, nonflammable (must be pre-heated before ignition can occur) liquid Sweet, chloroform-like odor.

Physical properties

Colorless liquid with a pleasant, sweet, chloroform-like odor

Uses

Intermediate in the production of vinylidene chloride; solvent.

Uses

Solvent for fats, oils, waxes, resins, other products; organic synthesis.

Uses

The use of 1,1,2-trichloroethane is quite restrictive. It is used to a slight extent as a specialty solvent and mostly as a chemical intermediate; a solvent for fats, waxes, natural resins, alkaloids, and various other organic materials; as an intermediate in production of vinylidene chloride and teflon tubing; and as a component of adhesives. The availability of other less toxic solvents discourages its use. More than 95% of this compound manufactured in the United States is consumed in producing vinylidene chloride. Domestic production is about 410 million pounds. It must not be confused with its much less toxic isomer, 1,1,1- trichloroethane.

Definition

ChEBI: A member of the class of chloroethanes that is ethane substituted by chloro groups at positions 1, 1 and 2.

General Description

A clear light colored liquid. Flash point between 0 and 74°F. Insoluble in water and slightly denser than water. Hence sinks in water. May be toxic by inhalation.

Reactivity Profile

1,1,2-Trichloroethane is sensitive to light and heat. Incompatible with strong oxidizing agents and strong bases. Reacts violently with sodium, potassium, magnesium, and aluminum. Attacks some plastics, rubber and coatings.

Health Hazard

Inhalation causes irritation of the nose, throat, and lungs. High concentrations may cause death by respiratory failure. Highly toxic by ingestion; may cause liver or kidney damage or myocardial irritability. Causes severe irritation of the gastrointestinal tract. Vapor may produce superficial skin burns or defatting type dermatitis and may irritate the eyes.

Safety Profile

Suspected carcinogen with experimental carcinogenic data. Poison by ingestion, intravenous, and subcutaneous routes. Moderately toxic by inhalation, skin contact, and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. An eye and severe skin irritant. Has narcotic properties and acts as a local irritant to the eyes, nose, and lungs. It may also be injurious to the liver and kidneys. Incompatible with potassium. When heated to decomposition it emits toxic fumes of Cl-. See also CHLORINATED HYDROCARBONS, ALIPHATIC; and other trichloroethane entries,

Potential Exposure

1,1,2-Trichloroethane is used as an intermediate in the production of vinylidine chloride, and a component of adhesives; as a solvent; but is not as widely used as is its isomer 1,1,1-Trichloroethane; it is an isomer of 1,1,1-Trichloroethane but should not be confused with it toxicologically. 1,1,2-Trichloroethane is comparable to carbon tetrachloride and tetrachloroethane in toxicity. Forms a flammable vaporair mixture at 43℃ and higher.

Carcinogenicity

According to the NCI, 1,1,2-trichloroethane has been included in the NCI bioassay program, in which it was fed by gavage to rats and mice. As in many of these studies with hepatotoxic compounds, hepatocellular carcinomas occurred in mice but not in rats fed for 78 weeks. Rats were kept an additional 35 weeks and mice 13 weeks following treatment. Pheochromocytomas were also observed in mice. The doses fed were 92 and 46 mg/kg/ day for rats and 390 and 195 mg/kg/day for mice. Mortality was accelerated in female mice but not in the rats or male mice. The NCI report does not indicate the degree of noncarcinogenic histopathology produced by these doses.
In a bioassay conducted by NCI, technical-grade (92.7% pure) 1,1,2-trichloroethane was administered by gavage in corn oil to Osborne–Mendel rats and B6C3F1 mice: (50/species/sex/dose) for each of two doses and 20 animals/ species/sex for each of two control groups. Administration was five times/week for 78 weeks, during which time doses for rats were increased from 70 and 30 mg/kg/day to 100 and 50 mg/kg/day and doses for mice were increased from 300 and 150 mg/kg/day to 400 and 200 mg/kg/day. By two statistical tests, treatment of mice was found to be associated with increased incidence of hepatocellular carcinomas. A dose-related increase in pheochromocytomas was also confirmed in female mice. Tumors found in treated but not control rats included adrenal cortical carcinomas; transitional cell carcinomas of kidney; renal tubular adenomas; and hemangiosarcomas of spleen, pancreas, abdomen, and subcutaneous tissue. There was, however, no statistically significant increase in tumor incidence in rats as a function of treatment.
IRIS classifies this compound as C, possible human carcinogen on the basis of hepatocellular carcinomas and pheochromocytomas in one strain of mice. Carcinogenicity was not shown in rats. 1,1,2-Trichloroethane is structurally related to 1,2-dichloroethane, a probable human carcinogen. There are no human carcinogenicity data.

Environmental Fate

Biological. Vinyl chloride was reported to be a biodegradation product from an anaerobic digester at a wastewater treatment facility (Howard, 1990). Under aerobic conditions, Pseudomonas putida oxidized 1,1,2-trichloroethane to chloroacetic and glyoxylic acids. Simultaneously, 1,1,2-trichloroethane is reduced to vinyl chloride exclusively (Castro and Belser,1990). In a static-culture-flask screening test, 1,1,2-trichloroethane was statically incubated in the dark at 25 °C with yeast extract and settled domestic wastewater inoculum. Biodegradative activity was slow to moderate, concomitant with a significant rate of volatilization (Tabak et al., 1981).
Chemical/Physical. Products of hydrolysis include chloroacetaldehyde, 1,1-dichloroethylene, and HCl. The aldehyde is subject to hydrolysis forming hydroxyacetaldehyde and HCl (Kollig, 1993). The reported half-life for this reaction at 20 °C is 170 yr (Vogel et al., 1987). Under alkaline conditions, 1,1,2-trichloroethane hydrolyzed to 1,2-dichloroethylene. The reported hydrolysis half-life in water at 25 °C and pH 7 is 139.2 yr (Sata and Nakajima, 1979).

Shipping

UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

Purification Methods

Purify the chloroethane as for 1,1,1-trichloroethane above. [Beilstein 1 IV 139.]

Structure and conformation

1,1,2-Trichloroethane (TCE) is liquid at room temperature, and below 237 K, it displays a monoclinic phase, referred to as phase α, characterized by the simultaneous presence of distinct molecular conformers and orientations, accompanied by site disorder close to the melting point. At high pressure, a different monoclinic solid phase is observed (referred to as phase β), which at room temperature is stable above 0.82 GPa. Different conformers are present in the different phases of TCE. The gauche conformer is energetically more stable in isolation and by far the most abundant in the gas phase, where intermolecular interactions are negligible. Vibrational and NMR studies on the pure solvent have shown instead that in the liquid phase, the C2H3Cl3 molecules exist in both gauche and transoid conformations with comparable concentrations. Only transoid conformers are observed in the β crystalline phase (at high pressure)[1].

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong acids, strong caustics; chemically active metals;, such as aluminum, magnesium powders, sodium, potassium. Attacks some plastics, rubber, coatings, steel, and zinc.

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced.

References

[1] Michela Romanini. “Simultaneous Orientational and Conformational Molecular Dynamics in Solid 1,1,2-Trichloroethane.” The Journal of Physical Chemistry C 122 10 (2018): 5774–5783.

1,1,2-Trichloroethane synthesis

Synthesis of 1,1,2-Trichloroethane from ETHYLENE

1,1,2-Trichloroethane Preparation Products And Raw materials

Raw materials

Trichloroethane 1,2-Dichloroethane PENTACHLOROETHANE 1,1-Dichloroethane Hexachloroethane

1,1,2,2-Tetrachloroethane

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Preparation Products

1,2-DICHLOROETHYLENE VINYLIDENE CHLORIDE Triethylamine hydrochloride 1,1,1-Trichloroethane VINYL CHLORIDE

2,3-DICHLOROPROPIONYL CHLORIDE 2-chloro-2-methylpropiononitrile N-(Methyl)-N-(p-toluenesulfonyl)ethynylamine, 97% 1,1,1,2-TETRACHLOROETHANE

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1,1,2-Trichloroethane Suppliers

Global( 222)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7377	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Xi'an Kono chem co., Ltd.,	029-86107037 13289246953	info@konochemical.com	China	2995	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81148696 +8615536356810	1047@dideu.com	China	3679	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Xiamen AmoyChem Co., Ltd	58
Xi'an Kono chem co., Ltd.,	58
Hubei xin bonus chemical co. LTD	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58

View Lastest Price from 1,1,2-Trichloroethane manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-12-24	1,1,2-Trichloroethane 79-00-5	US $2.00-2.00 / KG	1KG	99.5%	2000 ton/year	Henan Fengda Chemical Co., Ltd
2023-07-27	1,1,2-Trichloroethane 79-00-5	US $1.50 / g	1g	99.0% Min	100 Tons	Shaanxi Didu New Materials Co. Ltd
2020-01-09	1,1,2-Trichloroethane 79-00-5	US $0.10 / KG	1KG	99.0%	1000 tons	Shaanxi Dideu Medichem Co. Ltd

1,1,2-Trichloroethane
79-00-5
US $2.00-2.00 / KG
99.5%
Henan Fengda Chemical Co., Ltd

1,1,2-Trichloroethane
79-00-5
US $1.50 / g
99.0% Min
Shaanxi Didu New Materials Co. Ltd

1,1,2-Trichloroethane
79-00-5
US $0.10 / KG
99.0%
Shaanxi Dideu Medichem Co. Ltd

1,1,2-Trichloroethane Spectrum

1,1,2-Trichloroethane(79-00-5)MS 1,1,2-Trichloroethane(79-00-5)¹HNMR 1,1,2-Trichloroethane(79-00-5)¹³CNMR 1,1,2-Trichloroethane(79-00-5)IR1 1,1,2-Trichloroethane(79-00-5)IR2 1,1,2-Trichloroethane(79-00-5)Raman

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1,1,2-Trichlorethane 1,1,2-trichloro-ethan beta-Trichloroethane CHCl2CH2Cl Ethane trichloride ethanetrichloride freon140 NCI-C04579 R-140 Trojchloroetan(1,1,2) 1,2,1-Trichloroethane 1.1.2-Trichloroethane 5g [79-00-5] 1.1.2-Trichloroethane 10g [79-00-5] (1Mg/ML in Methanol) [for Water Analysis] 1,1,2-Trichloroethane 1,1,2-Trichloroethane, 98% 1LT 1,1,2-Trichloroethane, 98% 250ML 1.1.2-Trichlor 1,1,2-Trichloroethane contains <=3% 2-propanol as stabilizer, 97% 1,1,2-Trichloroethane Standard VINYL TRICHLORIDE 1,1,2-trichloroethane solution 1,1,2- or 1,2,2-Trichloroethane 1,1,2-Trichloroethane (1mg/ml in Methanol) [for Water Analysis] 1,1,2-TRICHLOROETHANE 1,1,2-TRICHLOROETHANE (VINYL TRICHLORIDE) Trichloroethane, 1,1,2-Vinyl trichloride 1,1,2-Trichoroethane 1,1,2-TRICHLOROETHANE OEKANAL 1,1,2-TRICHLOROETHANE (STABILIZED WITH 2 -PROPANOL), 97% 1,1,2-TRICHLOROETHANE, 5000MG, NEAT 1,1,2-TRICHLOROETHANE, 1X1ML, MEOH, 200U G/ML 1,1,2-TRICHLOROETHANE, STANDARD FOR GC 1,1,2-TrichloroethaneSolution,100mg/L,1ml 1,1,2-Trichloroethane > 1,1,2-TrichloroethaneSolution,1,000mg/L,1ml 1,1,2-TrichloroethaneSolution,2,000mg/L,1ml 1,1,2-TrichloroethaneSolution,5,000mg/L,2x5ml 1,1,2-Trichloroethane ISO 9001：2015 REACH 1,1,2-Trichloroethane,98% 1,1,2-tce 1,1,2-Trichlorethan 1,2,2-Trichloroethane beta-T Ethane,1,1,2-trichloro- Vinyl trichloride,β-Trichloroethan 1,1,2-TRICHLOROETHANE, 1X1ML, MEOH, 5000 UG/ML 79-00-5 CH2CHCl3 Cl2CHCHClCH3 ClCH2CHCl2 CH2ClCHCl2 79005 Analytical Standards Building Blocks Alkyl Analytical Chromatography Product Catalog Standard Solutions (VOC)