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Chromium picolinate

Product Features Chromium Precautions Uses
Chromium picolinate
Chromium picolinate
Chemical Name:
Chromium picolinate
CrPic;Cr(pic)3;Ccris 8310;CHROME PICOLINATE;Chromium benzoate;ChromiumPiconilate;CHROMIUM PICOLINATE;Picolinate ChroMiuM;Picolinic acid chrom;CHROMIUM PICOLINATE NF
Molecular Formula:
Formula Weight:
MOL File:

Chromium picolinate Properties

storage temp. 
room temp
CAS DataBase Reference
14639-25-9(CAS DataBase Reference)
EPA Substance Registry System
Chromium, tris(2-pyridinecarboxylato-. kappa.N1,.kappa.O2)-(14639-25-9)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  20/21/22-36/37/38
Safety Statements  22-36/37/39-36-26
RTECS  US5647790
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P501 Dispose of contents/container to..…

Chromium picolinate price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C4124 Chromium picolinate ≥98% (HPLC) 14639-25-9 5g $261 2017-11-08 Buy
Sigma-Aldrich 1133638 Chromium picolinate United States Pharmacopeia (USP) Reference Standard 14639-25-9 100mg $302.1 2017-11-08 Buy
TCI Chemical P1347 Chromium(III) Pyridine-2-carboxylate >96.0%(T) 14639-25-9 5g $46 2017-11-08 Buy
TCI Chemical P1347 Chromium(III) Pyridine-2-carboxylate >96.0%(T) 14639-25-9 25g $163 2017-11-08 Buy
Sigma-Aldrich C4124 Chromium picolinate ≥98% (HPLC) 14639-25-9 25g $890 2017-11-08 Buy

Chromium picolinate Chemical Properties,Uses,Production

Product Features

Chromium picolinate appears as fine purple crystalline powder with good fluidity. It is chemically stable at room temperature and is slightly soluble in water but insoluble in ethanol, wherein the chromium is in the trivalent form. The whole molecule structure is electrically neutral and has hydrophobic properties. Therefore, it is possible to perform the trans-membrane absorption on the intact structure with the molecular structure being similar to the GTF part. In 1977, Toepfer thought that GTF is the biologically active form of chromium with its structure being the complex formed between nicotinic acid chromium and aspartic acid, glutamic acid, glycine and cysteine. The GTF-like structure of chromium picolinate class determines its own excellent absorption rate and can more effectively play its biological function. It is reported that the absorption rate of formulation of ordinary chromium was about 0.5% while the absorption rate of chromium is 2%-5% (Anderson, 1996).
Chromium picolinate is a health supplement for strengthening muscles and promoting weight. It can increase the amount of the active AMP protein kinase (AMPK) related with metabolism pathway inside the skeletal cells, thereby improving energy balance and insulin function. The main effects are as follows:
1, It can improve the proportion of lean meat, reduce fat as well as improve carcass quality.
2, It can improve the capability of stress resistance and immunity. Stress can cause reduced animal production while niacin chromium, through its anti-stress effect, may increase the production of animal products.
Chromium is an essential mineral, it is the indispensable substance for the release of active insulin during the carbohydrates, fat and protein metabolism. In August 2005, the US Food and Drug Administration (FDA) had approved the production of chromium picolinate, and confirmed that it is safe for being applied to the treatment of human insulin resistance and type II diabetes. The main basis for FDA for made this judgment was the early, randomized, and double-blinded and placebo therapy conducted by Dr. Cefalu who had shown that chromium picolinate can significantly improves the insulin sensitivity of the patients of the high-risk diabetic.
The dietary reference Intakes amount of chromium (adults) provided by our country is AI = 50ug per day, UL= 500 ug per day for Chinese Residents.
In the "Declaration of nutrient supplements and review Provisions", the minimum amount of chromium is 15ug/day while the maximum amount is 150ug/day.


Chromium is one of 12 kinds of essential trace metal element. In natural environment, chromium is presented in various valence states from Cr to Cr6 + with Cr, Cr2 +, Cr3 +, Cr6 + being the most widely existed. Cr3 + is an essential trace element in the human body and is the form of the entire chromium inside human body. It is the component comprising glucose tolerance factor with the insulin-like effects. Therefore, it can promote glucose utilization of cells, promote the oxidative phosphorylation of glucose, promote glycogen promote synthesis as well as improve the stability of insulin, thereby reducing blood sugar level. Its physiological role has been increasingly drawn the attention of researchers. Studies have shown that: chromium is closely related to glucose metabolism, lipid metabolism, protein metabolism and nucleic acid metabolism. It has also found that many kinds of animals have strong chromium tolerance with the capability of tolerating 3000 mg/kg of chromium oxide and 1000 mg/kg of chromium chloride. Chromium picolinate, as organic chromium preparation, has their safety being drawn a growing concern. In livestock production, chromium picolinate can significant promotion effect on alleviating environmental stress, increasing lean meat rate and increasing the endurance and is thus widely used. However, for their usage amount, although some countries have ratified chromium picolinate to be added to poultry diets, currently there has not yet of officially released minimum requirement and maximum tolerated dose data of animals. Studies have reported that normal physiological plasma concentration of chromium is 0.1-2.1μg/ml (Cerulli et al., 1998), the physiological concentrations of chromium in human liver was 5.4-470ηg ​​/ g liver wet weight (-0.1-9μM) (Versieck, 1985). Excessive addition (much higher than physiological dose) may produce toxicity DNA and cytotoxicity.
The above information is edited by the chemicalbook of Dai Xiongfeng.


At present, according the research of domestic and international research institutions and Nutrition Institute, long-term intake of chromium ≥1000ug/day can easily lead to poisoning. The maximal allowable consumption amount for health food is 250ug/day.
1, excess iron and zinc can hinder and inhibit the absorption of chromium.
2, manganese and chromium have mutually reinforcing roles in the regulation of glucose metabolism.
3, chromium and magnesium can synergistically promote the sugar conversion.
4, there is no need for increasing daily sugar protein and lysine levels.


It can be used as a medicine and health products as well as food additives.
Chromium picolinate (CrPic) is taken as the supplement or alternative medicine for type 2 diabetes. Experimental evidence has indicated CrPic boost glucose uptake via activating P38 MAPK. Chromium is thought to be able to enhance the action of insulin, thereby increasing insulin sensitivity in type 2 diabetes patients

Chemical Properties

Dark violet crystal

Chromium picolinate Preparation Products And Raw materials

Raw materials

Preparation Products

Chromium picolinate Suppliers

Global( 202)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20811 55
Hubei XinghengKang Chemical Technology Co., Ltd. 027-88878869 18162384755
027-88878869 China 259 58
Hubei Yuancheng Saichuang Technology Co., Ltd. 18062666868/13048470578 QQ2355779403/2355880551
023-60363599,027-68886696,, China 3011 58
Rhawn Reagent 400-133-2688
021-57461626 China 13720 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96820 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) China 40398 62
INTATRADE GmbH +49 3493/605464
+49 3493/605470 Germany 3588 66
TAIYUAN RHF CO.,LTD. +86 351 7031519
+86 351 7031519 China 2362 56
TCI (Shanghai) Development Co., Ltd. 800-988-0390
021-67121385 China 22830 81
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 China 44192 61

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