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Bosentan hydrate

Bosentan hydrate structure

CAS No.: 157212-55-0

Chemical Name:: Bosentan hydrate

Synonyms: CS-170;Bosetan;bosentan hydrate;Bosentan (200 mg);Bosentan (1076115);Bosentan monohydrate;Bosentan hydrate USP/EP/BP;Bosentan Hydrate See B675900;Bosentan Hydrate (Ro 47-0203);Tracleer, Bosentan monohydrate

CBNumber:: CB6547457

Molecular Formula:: C27H31N5O7S

Molecular Weight:: 569.62934

MDL Number:: MFCD09751188

MOL File:: 157212-55-0.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:00

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Bosentan hydrate Properties

Melting point	114-118 °C
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Very Slightly, Heated)
form	powder
color	white to beige
Merck	14,1353
FDA UNII	Q326023R30

SAFETY

Risk and Safety Statements

Hazard statements	H412
Precautionary statements	P273
HS Code	2935909550

Bosentan hydrate price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1265	Bosentan hydrate ≥98% (HPLC)	157212-55-0	10MG	$108	2023-06-20	Buy
Sigma-Aldrich	SML1265	Bosentan hydrate ≥98% (HPLC)	157212-55-0	50MG	$438	2023-06-20	Buy
Sigma-Aldrich	PHR2708	Bosentan certified reference material, pharmaceutical secondary standard	157212-55-0	500MG	$349	2022-05-15	Buy
Sigma-Aldrich	1076115	Bosentan United States Pharmacopeia (USP) Reference Standard	157212-55-0	200MG	$818	2022-05-15	Buy
TCI Chemical	B5118	Bosentan Monohydrate >98.0%(HPLC)	157212-55-0	25mg	$57	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML1265	10MG	$108	Buy
SML1265	50MG	$438	Buy
PHR2708	500MG	$349	Buy
1076115	200MG	$818	Buy
B5118	25mg	$57	Buy

Bosentan hydrate Chemical Properties,Uses,Production

Uses

Antagonist (endothelin receptor).

Uses

Bosentan hydrate has been used in cell viability assay. It has also been used as a positive control for calcium transient analysis.

Definition

ChEBI: Bosentan hydrate is a hydrate. It contains a bosentan.

brand name

Tracleer (Actelion).

Biological Activity

a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a relatively higher affinity to the endothelin a receptor than endothelin b receptor. by competitively binding to endothelin a and endothelin b receptors in the endothelium and vascular smooth muscle, bosentan offset the effect of endothelin which is an extremely potent endogenous vasoconstrictor and broncho-constrictor. in addition, bosentan decreases both pulmonary and systemic vascular resistance and is particularly applied in the treatment of pulmonary arterial hypertension. [1]

Biochem/physiol Actions

Bosentan is an endothelin receptor antagonist. Endothelin is a potent vasoconstrictor, making antagonists of clinical interest for the treatment of conditions associated with vasospasm, such as subarachnoid hemorrhage (SAH) and hypertension. Bosentan is a dual endothelin receptor antagonist effective in the treatment of pulmonary arterial hypertension (PAH), the first of the class to make it to market. Bosentan is an orally available, competitive antagonist of both the ETA and ETB receptor subtypes with a Ki of 4.7 nM for ETA and a Ki of 95 nM for ETB.

in vitro

a study was performed in vitro to measure the influence of bosentan on the angiogenic performance of dermal microvascular endothelial cells (mvecs) and to detect the capacity of bosentan in offsetting the antiangiogenic effects of systemic sclerosis sera. it was found that bosentan significantly increased cell viability and offset the antiangiogenic effects of systemic sclerosis sera on dermal mvecs. [2]

in vivo

a study was conducted to investigate the effect of bosentan on plasma leptin level after myocardial infarction in wistar rats. after oral administration of bosentan once daily at the dose of 100 mg/kg for 2 days, concentration of leptin in plasma significantly increased. this finding revealed that bosentan played an crucial role on regulating leptin concentration in ischemic cardiovascular pathology. [1]

IC 50

inhibiting endothelin receptor a and b with an ic50 of 15.1 ± 1.6 μm in p388/dx cells.

References

[1] ostrowski rp, januszewski sa, kowalska za and kapuscinski a. effect of endothelin receptor antagonist bosentan on plasma leptin concentration in acute myocardial infarction in rats. pathophysiology. 2003 sep; 9(4): 249-56.
[2]romano e, bellando-randone s, manetti m, bruni c, lepri g, matucci-cerinic m, guiducci s. bosentan blocks the antiangiogenic effects of sera from systemic sclerosis patients: an in vitro study. clin exp rheumatol. 2015 aug; 33(4 suppl 91): s148-52.
[3]rubin lj, badesch db, barst rj, galiè n, black cm et, al. bosentan therapy for pulmonary arterial hypertension. new engl j med. 2002 mar; 346 (12): 896-903.

Bosentan hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Bosentan hydrate Suppliers

Global( 361)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
HubeiwidelychemicaltechnologyCo.,Ltd	18627774460	faith@widelychemical.com	CHINA	742	58
Shochem(Shanghai) Co.,Ltd	86-21-50800795	info@shochem.com	CHINA	288	58
Chengdu Feibo Pharm Technology Co., Ltd	15982321820	abby@arkpharm.com	CHINA	3279	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Chengdu Aslee Biopharmaceuticals, Inc.	28-85305008		CHINA	964	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
HubeiwidelychemicaltechnologyCo.,Ltd	58
Shochem(Shanghai) Co.,Ltd	58
Chengdu Feibo Pharm Technology Co., Ltd	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Chengdu Aslee Biopharmaceuticals, Inc.	58

View Lastest Price from Bosentan hydrate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-11-27	Bosentan hydrate 157212-55-0	US $0.20 / g	100g	99.99%	5ton/Month	Qiuxian Baitai New Material Co., LTD
2021-10-08	Bosentan hydrate 157212-55-0	US $0.00-0.00 / g	1g	98%+	100kgs	Wuhan Nutra Biotechnology Co.,Ltd
2021-07-13	Bosentan hydrate 157212-55-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Bosentan hydrate
157212-55-0
US $0.20 / g
99.99%
Qiuxian Baitai New Material Co., LTD

Bosentan hydrate
157212-55-0
US $0.00-0.00 / g
98%+
Wuhan Nutra Biotechnology Co.,Ltd

Bosentan hydrate
157212-55-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Bosentan hydrate Spectrum

Bosentan hydrate(157212-55-0)¹HNMR

157212-55-0(Bosentan hydrate)Related Search:

POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE Bosentan (Trifluoromethoxy)benzene Guaiacol p-Anisaldehyde

4-Methoxyphenol ERBIUM (III) 2,4-PENTANEDIONATE Anisole Ethoxyquin 4-Methoxybenzyl cyanide

2,2'-BIPYRIMIDINE 5,6-Dimethoxypyrimidin-4-ylamine 4-AMINO-6-HYDROXY-2-METHYLPYRIMIDINE DIHYDRATE 4-tert-Butylbenzenesulfonamide 4-AMINO-6-HYDROXY-2-METHYLPYRIMIDINE

tert-Butylbenzene Hydroxy Bosentan hydrate

1of4

Bosetan 4-(tert-Butyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfona 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-Methoxyphenoxy)-2-(pyriMidin-2-yl)pyriMidin-4-yl]benzene-1-sulfonaMide Bosentan Hydrate See B675900 Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-, hydrate (1:1) Bosentan (200 mg) bosentan hydrate Bosentan monohydrate 4-(1,1-dimethylethyl)-n-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)(2,2'-bipyrimidin)-4-yl)benzenesulfonamide monohydrate CS-170 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzene-1-sulfonamide hydrate Bosentan hydrate USP/EP/BP Bosentan Hydrate (Ro 47-0203) 4-(tert-Butyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide hydrate[Ro-47-0203 Hydrate Bosentan MonohydrateQ: What is Bosentan Monohydrate Q: What is the CAS Number of Bosentan Monohydrate Q: What is the storage condition of Bosentan Monohydrate Q: What are the applications of Bosentan Monohydrate Bosentan HydrateQ: What is Bosentan Hydrate Q: What is the CAS Number of Bosentan Hydrate Q: What is the storage condition of Bosentan Hydrate Q: What are the applications of Bosentan Hydrate Bosentan (1076115) Tracleer, Bosentan monohydrate Bosentan Monohydrate/Bosentan Hydrate 4-(tert-Butyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl)benzenesulfonamide hydrate 157212-55-0 C27H29N5O6SH2O 9N5O6SH2O C27H31N5O7S C27H29N5O6S2O Inhibitors API Heterocyclic Compounds