ChemicalBook >> CAS DataBase List >>Methoxycarbonyl-L-tert-leucine
Methoxycarbonyl-L-tert-leucine
- CAS No.
- 162537-11-3
- Chemical Name:
- Methoxycarbonyl-L-tert-leucine
- Synonyms
- (S)-2-acetamido-3,3-dimethylbutanoic acid;MOC-L-tert.Leucine;N-Methoxycarbonyl-tert-leucine;(S)-2-(MethoxycarbonylaMino)-3,3-diMethylbutanoic acid;Moc-L-tle;Moc-Tle-OH;MOC-L-Norleucine;Moc-L-tert-lecine;MOC-L-tert. Leucin;Atazanavir USP RC A
- CBNumber:
- CB6663762
- Molecular Formula:
- C8H15NO4
- Molecular Weight:
- 189.21
- MDL Number:
- MFCD07778455
- MOL File:
- 162537-11-3.mol
Last updated:2024-04-16 16:23:18
| Melting point | 1090C |
|---|---|
| Boiling point | 320.9±25.0 °C(Predicted) |
| Density | 1.126±0.06 g/cm3(Predicted) |
| vapor pressure | 0Pa at 25℃ |
| storage temp. | 2-8°C |
| solubility | Soluble in ethyl acetate and methanol. |
| pka | 4.46±0.10(Predicted) |
| form | powder |
| Water Solubility | 26.4g/L at 20℃ |
| InChI | InChI=1S/C8H15NO4/c1-8(2,3)5(6(10)11)9-7(12)13-4/h5H,1-4H3,(H,9,12)(H,10,11)/t5-/m1/s1 |
| InChIKey | NWPRXAIYBULIEI-RXMQYKEDSA-N |
| SMILES | C(O)(=O)[C@H](C(C)(C)C)NC(OC)=O |
| LogP | 0.832 at 21℃ |
| FDA UNII | 0L7G8ZHR2P |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2933399090 | |||||||||
| NFPA 704 |
|
Methoxycarbonyl-L-tert-leucine price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR3001 | Atazanavir Related Compound A pharmaceutical secondary standard, certified reference material | 162537-11-3 | 50MG | $461 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1044356 | Atazanavir Related Compound A United States Pharmacopeia (USP) Reference Standard | 162537-11-3 | 25mg | $1210 | 2024-03-01 | Buy |
| Alfa Aesar | H35148 | N-Methoxycarbonyl-L-tert-leucine, 98% | 162537-11-3 | 5g | $147 | 2021-12-16 | Buy |
| Alfa Aesar | H35148 | N-Methoxycarbonyl-L-tert-leucine, 98% | 162537-11-3 | 1g | $37.3 | 2021-12-16 | Buy |
| Alfa Aesar | H35148 | N-Methoxycarbonyl-L-tert-leucine, 98% | 162537-11-3 | 25g | $593 | 2021-12-16 | Buy |
Methoxycarbonyl-L-tert-leucine Chemical Properties,Uses,Production
Description
Methoxycarbonyl-L-tert-leucine is a kind of amino acid deriviative. It is a very useful intermediate for efficient synthesis of the HIV protease inhibitor BMS-232632 as well as atazanavir bisulfate.
References
Zhongmin Xu, †, et al. "Process Research and Development for an Efficient Synthesis of the HIV Protease Inhibitor BMS-232632." Organic Process Research & Development 6.3(2002):323-328.
Simhadri, Srinivas. "Process for the preparation of atazanavir bisulfate." (2016).
https://www.alfa.com/en/search/?q=14328-63-3
Chemical Properties
White Solid
Uses
The coupling of the two key intermediates, N-(methoxycarbonyl)-l-tert-leucine acylated benzyl hydrazine and chloromethyl ketone, via an S N 2 reaction furnished the amino ketone in high yield under our optimized conditions in practical synthesis of the HIV Protease Inhibitor Atazanavir via a Highly diastereoselective Reduction Approach.
Flammability and Explosibility
Not classified
Methoxycarbonyl-L-tert-leucine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 447)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| weifang runzhong fine chemical co., ltd | 536-7868377 +8618653686003 | sq@runzhongchem.com | China | 187 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2141 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 | sales@zhswyy.com | China | 296 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7378 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| Taizhou Tianhong Biochemistry Technology Co., Ltd. | 0523-86132544 | sales@thbiochem.com | CHINA | 305 | 60 |
View Lastest Price from Methoxycarbonyl-L-tert-leucine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-16 | Methoxycarbonyl-L-tert-leucine
162537-11-3
|
US $5.00-0.10 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2024-04-10 | N-Methoxycarbonyl-L-tert-Leucine
162537-11-3
|
US $0.00 / kg | 1kg | 99% | 20tons | Shanghai Joiny Pharmaceutical Co.,LTD | |
 |
2024-04-07 | Methoxycarbonyl-L-tert-leucine
162537-11-3
|
US $0.00-0.00 / kg | 0.10000000149011612kg | 99 | 20tons | Chongqing Zhihe Biopharmaceutical Co., Ltd. |
-
- Methoxycarbonyl-L-tert-leucine
162537-11-3
- US $5.00-0.10 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- N-Methoxycarbonyl-L-tert-Leucine
162537-11-3
- US $0.00 / kg
- 99%
- Shanghai Joiny Pharmaceutical Co.,LTD
-
- Methoxycarbonyl-L-tert-leucine
162537-11-3
- US $0.00-0.00 / kg
- 99
- Chongqing Zhihe Biopharmaceutical Co., Ltd.
162537-11-3(Methoxycarbonyl-L-tert-leucine)Related Search:
(S)-2-Methoxycarbonylamino-3,3-dimethylbutyric acid
Methoxycarbonyl-L-tert-leucine
N-(Methoxycarbonyl)-3-methyl-L-valine
Atazanavir related coMpound A
MOC-L-tert. Leucin
L-Valine,N-(Methoxycarbonyl)-3-Methyl-
Moc-L-tert-lecine
(S)-2-(Methoxycarbonyl)-3,3-diMethylbutanoic acid
Methyl Carbonyl L-tert Leucine
(2S)-2-ACETAMIDO-3,3-DIMETHYLBUTANOIC ACID
N-Moc-L-tert-Leucine
(S)-N-(METHOXYCARBONYL)-TERT-LEUCINE
Methylcarbonyl-L-t-Leucine
Atazanavir USP Related Compound A
Methoxycarbonyl-L-tert-leucinef
Atazanavir side chain
Atazanavir Impurity 15
Atazanavir USP RC A
N-Methoxycarbonyl-L-tert-leucine,98%
Methoxycarbonyl-L-tert-leucine USP/EP/BP
Moc-Tle-OH
Atazanavir Related Compund A (Methoxycarbonyl-L-tert-leucine)
Atazanavir Related Compound A ((S)-2-[(Methoxycarbonyl)amino]-3,3-dimethylbutanoic acid) (1044356)
MOC-L-tert.Leucine
N-Methoxycarbonyl-tert-leucine
(S)-2-(MethoxycarbonylaMino)-3,3-diMethylbutanoic acid
(S)-2-acetamido-3,3-dimethylbutanoic acid
Atazanavir Sulfate Impurity K
MOC-L-Norleucine
Atazanavir Sulfate EP Impurity K
Moc-L-tle
N-(Methoxycarbonyl)-tert-L-leucine
162537-11-3
C38H54N6O11S
Amino Acid Derivatives
Amino Acids 13C, 2H, 15N
Amino Acids & Derivatives
Chiral Reagents