4-Cyanophenol
- CAS No.
- 767-00-0
- Chemical Name:
- 4-Cyanophenol
- Synonyms
- 4-HYDROXYBENZONITRILE;4-HYDROXYBENZOHYDRAZIDE;P-CYANOPHENOL;PARA-CYANOPHENOL;Hydroxybenzonitrile;Benzonitrile, 4-hydroxy-;P-nitrile;AKOS 217-25;AKOS B004225;4-CYANOPHENOL
- CBNumber:
- CB6681698
- Molecular Formula:
- C7H5NO
- Molecular Weight:
- 119.12
- MDL Number:
- MFCD00002312
- MOL File:
- 767-00-0.mol
- MSDS File:
- SDS
| Melting point | 110-113 °C(lit.) |
|---|---|
| Boiling point | 146 °C / 2mmHg |
| Density | 1.1871 (rough estimate) |
| refractive index | 1.5800 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | methanol: 0.1 g/mL, clear |
| form | Crystalline Powder |
| pka | 7.97(at 25℃) |
| color | Off-white to beige-gray |
| Water Solubility | slightly soluble |
| BRN | 386130 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 767-00-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 1S13529YJU |
| NIST Chemistry Reference | 4-Hydroxybenzoic acid nitrile(767-00-0) |
| EPA Substance Registry System | Benzonitrile, 4-hydroxy- (767-00-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36-45-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DI4375000 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29269095 | |||||||||
| NFPA 704 |
|
4-Cyanophenol price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C94009 | 4-Cyanophenol 95% | 767-00-0 | 5g | $36.4 | 2024-03-01 | Buy |
| TCI Chemical | C0842 | 4-Hydroxybenzonitrile >98.0%(GC)(T) | 767-00-0 | 25g | $23 | 2024-03-01 | Buy |
| TCI Chemical | C0842 | 4-Hydroxybenzonitrile >98.0%(GC)(T) | 767-00-0 | 500g | $220 | 2024-03-01 | Buy |
| Alfa Aesar | A15803 | 4-Hydroxybenzonitrile, 98+% | 767-00-0 | 50g | $63.65 | 2024-03-01 | Buy |
| Alfa Aesar | A15803 | 4-Hydroxybenzonitrile, 98+% | 767-00-0 | 100g | $105.65 | 2024-03-01 | Buy |
4-Cyanophenol Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder or chips. 4-Hydroxybenzonitrile [767-00-0], 4-cyanophenol, 1-cyano-4-hydroxybenzene, Mr 119.2, forms colorless crystals of mp 113℃. 4-Hydroxybenzonitrile is produced by reaction of 4-bromophenol with copper (I) cyanide, by ammoxidation of p-cresol, by reaction of 4-chlorobenzonitrile with sodium methoxide, or by the catalyzed gas phase reaction of ethyl 4-hydroxybenzoate with ammonia. The nitrile is used for the production of the herbicides 3,5-dibromo- and 3,5-diiodo-4- hydroxybenzonitrile (Bromoxynil, Ioxynil, May & Baker).
Uses
Intermediates of Liquid Crystals
Uses
4-Cyanophenol is a precursor for the synthesis of a vasodilator, Levcromakalim. Bromination of 4-cyanophenol results in bromoxynil, a commercial herbicide. It can also be used as a component of deep eutectic solvent (DES) mixture.
Preparation
4-Cyanophenol is produced by reaction of 4-bromophenol with copper (I) cyanide, by ammoxidation of p-cresol, by reaction of 4-chlorobenzonitrile with sodium methoxide, or by the catalyzed gas phase reaction of ethyl 4-hydroxybenzoate with ammonia.
Definition
ChEBI: 4-cyanophenol is a member of phenols. It has a role as an EC 1.4.3.4 (monoamine oxidase) inhibitor. It is functionally related to a benzonitrile.
Synthesis Reference(s)
The Journal of Organic Chemistry, 39, p. 3343, 1974 DOI: 10.1021/jo00937a007
Purification Methods
Crystallise the phenol from pet ether, *benzene or water and keep it under vacuum over P2O5. [Bernasconi & Paschelis J Am Chem Soc 108 2969 1986.] [Beilstein 10 H 167, 10 IV 441.]
4-Cyanophenol Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ENBRIDGE PHARMTECH CO., LTD. | +8613812269233 | tinayang@enbridgepharm.com | China | 303 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7613 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
View Lastest Price from 4-Cyanophenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-16 | 4-Cyanophenol
767-00-0
|
US $5.00-0.10 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-09-08 | 4-Cyanophenol
767-00-0
|
US $50.00 / kg | 1kg | 99% | 10000tons | Anhui Ruihan Technology Co., Ltd | |
 |
2023-03-06 | 4-Cyanophenol P-Cyanophenol
767-00-0
|
US $19.00 / KG | 1KG | 99.% | 50 ton | Hebei Guanlang Biotechnology Co,.LTD |
-
- 4-Cyanophenol
767-00-0
- US $5.00-0.10 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4-Cyanophenol
767-00-0
- US $50.00 / kg
- 99%
- Anhui Ruihan Technology Co., Ltd
-
- 4-Cyanophenol P-Cyanophenol
767-00-0
- US $19.00 / KG
- 99.%
- Hebei Guanlang Biotechnology Co,.LTD