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Dynorphin A (1-13)

Dynorphin A (1-13) structure

CAS No.: 72957-38-1

Chemical Name:: Dynorphin A (1-13)

Synonyms: Dyn(1-13);YGGFLRRIRPKLK;DYNORPHIN 1-13;DYNORPHIN A (1-13);sh-Oligopeptide-71;Dynorphin A1-13【pig】;Dynorphin A(1-13)【pig】;Dynorphin A(1-13)【rat】;DYNORPHIN A(HUMAN, 1-13);Dynphin A (1-13) Acetate

CBNumber:: CB6699152

Molecular Formula:: C75H126N24O15

Molecular Weight:: 1603.95

MDL Number:: MFCD00076366

MOL File:: 72957-38-1.mol

Last updated:2024-03-27 11:49:37

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Dynorphin A (1-13) Properties

Density	1.39±0.1 g/cm3(Predicted)
RTECS	JV7436666
storage temp.	Inert atmosphere,Store in freezer, under -20°C
form	Solid
pka	3.31±0.10(Predicted)
Water Solubility	Water: ≥ 60 mg/mL (37.41 mM)
Sequence	H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH
InChIKey	OVVIBUHLQIYUEU-JASZZEBFNA-N
FDA UNII	VFC23V742Z

SAFETY

Risk and Safety Statements

WGK Germany	3
HS Code	2933998090

Dynorphin A (1-13) price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	D7017	Dynorphin A Porcine Fragment 1-13 ≥97% (HPLC)	72957-38-1	1mg	$190	2024-03-01	Buy
Alfa Aesar	J64015	Dynorphin A (1-13), porcine	72957-38-1	1mg	$54.3	2023-06-20	Buy
Alfa Aesar	J64015	Dynorphin A (1-13), porcine	72957-38-1	5mg	$219	2023-06-20	Buy
Apolloscientific	BISN0009	PorcineDynorphinA(1-13) 99%	72957-38-1	5mg	$225	2021-12-16	Buy
AK Scientific	9669AJ	DynorphinA(1-13)	72957-38-1	5mg	$207	2021-12-16	Buy

Product number	Packaging	Price	Buy
D7017	1mg	$190	Buy
J64015	1mg	$54.3	Buy
J64015	5mg	$219	Buy
BISN0009	5mg	$225	Buy
9669AJ	5mg	$207	Buy

Dynorphin A (1-13) Chemical Properties,Uses,Production

Description

Dynorphin A(1-13), a tridecapeptide of the endogenous opioid peptides, has modest effects in reducing mild opiate withdrawal in humans. Previous studies revealed that dynorphin also potentiates the analgesic effect of morphine in morphine-tolerant rats and mice. The therapeutic potential of dynorphin A(1-13) is limited due to extensive metabolism by human metabolic enzymes resulting in an in vivo half-life of less than one minute. Chemical modifications of dynorphin A(1-13), such as N-methylation of Tyr1 and amidation of the C-terminus have been shown to be effective in protecting against the proteolytic enzymes in human plasma^[1].

Application

Dynorphin A (1-13) has been used as a test compound in the field asymmetric waveform ion mobility spectrometry coupled to mass spectrometry (FAIMS/IMS/MS).

Biochem/physiol Actions

Dynorphin A (1-13), a bioactive product of dynorphin A displays interaction with N-methyl- D-aspartate (NMDA) as well as with opioid receptors. It elevates intracellular calcium [Ca²⁺]i level and contributes to the loss of neurons affecting neuronal viability.

References

[1] B BRUGOS; G H. Metabolism of dynorphin A(1-13).[J]. Pharmazie, 2004.

Dynorphin A (1-13) synthesis

Synthesis of Dynorphin A (1-13) from L-Lysine, N-[(phenylmethoxy)carbonyl]-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-N5-[imino[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino]methyl]-L-ornithyl-N5-[imino[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino]methyl]-L-ornithyl-L-isoleucyl-N5-[imino[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino]methyl]-L-ornithyl-L-prolyl-N6-[(1,1-dimethylethoxy)carbonyl]-L-lysyl-L-leucyl-N6-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester

Dynorphin A (1-13) Preparation Products And Raw materials

Raw materials

L-Lysine, N-[(phenylmethoxy)carbonyl]-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-N5-[imino[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino]methyl]-L-ornithyl-N5-[imino[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino]methyl]-L-ornithyl-L-isoleucyl-N5-[imino[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino]methyl]-L-ornithyl-L-prolyl-N6-[(1,1-dimethylethoxy)carbonyl]-L-lysyl-L-leucyl-N6-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester

Preparation Products

Dynorphin A (1-13) Suppliers

Global( 159)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chengdu Youngshe Chemical Co., Ltd.	+8618108235634	Cecilia@youngshechem.com	China	2345	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Apextide Co Ltd	+undefined15700198315	senjie.hou@sinopep.com	China	71	58
Henan Tengmao Chemical Technology Co. LTD	+8615238638457	salesvip2@hntmhg.com	China	415	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	616	58
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58

Supplier	Advantage
Chengdu Youngshe Chemical Co., Ltd.	58
Henan Bao Enluo International TradeCo.，LTD	58
Apextide Co Ltd	58
Henan Tengmao Chemical Technology Co. LTD	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Nantong Guangyuan Chemicl Co,Ltd	58
Alpha Biopharmaceuticals Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58

View Lastest Price from Dynorphin A (1-13) manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-03-21	Dynorphin A (1-13) 72957-38-1	US $110.00-90.00 / kilogram	1kilogram	99%	10 tons/per week	Henan Tengmao Chemical Technology Co. LTD
2024-03-08	Dynorphin A (1-13) 72957-38-1	US $10.00 / kg	1kg	99%	1000kg	Nantong Guangyuan Chemicl Co,Ltd
2024-01-02	Dynorphin A (1-13) 72957-38-1	US $75.00-750.00 / kg	10kg	0.99	20tons	Zibo Hangyu Biotechnology Development Co., Ltd

Dynorphin A (1-13)
72957-38-1
US $110.00-90.00 / kilogram
99%
Henan Tengmao Chemical Technology Co. LTD

Dynorphin A (1-13)
72957-38-1
US $10.00 / kg
99%
Nantong Guangyuan Chemicl Co,Ltd

Dynorphin A (1-13)
72957-38-1
US $75.00-750.00 / kg
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

72957-38-1(Dynorphin A (1-13))Related Search:

DYNORPHIN B (1-13) H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH LEU-ENKEPHALIN-ARG dynorphin B (1-29) DYNORPHIN B (1-9)

TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS-TRP-ASP-ASN-GLN-NH2 Dynorphin A (1-13) L-LEUCYL-L-ALANINE (D-ARG6)-DYNORPHIN A (1-13),[D-ARG6]-DYNORPHIN A (1-13), PORCINE DYNORPHIN A (2-13), PORCINE,DYNORPHIN A (2-13)

dynorphin amide (1-13), Ala(2)-(5-F-Phe)(4)- [D-ALA2]-DYNORPHIN A (1-13) AMIDE,[DALA2] DYNORPHIN A (1-13), AMIDE, PORCINE [DALA2, DARG6] DYNORPHIN A, (1-13), PORCINE,(D-ALA2,D-ARG6)-DYNORPHIN A (1-13) (ARG11,13)-DYNORPHIN A (1-13)-GLY-NH-(CH2)5-NH2,(ARG11,13)-DYNORPHIN A (1-13)-GLY-5-AMINO-PENTYLAMIDE DYNORPHIN A (1-11) AMIDE

DYNORPHIN A (1-10) AMIDE H-LYS-LEU-NH2 LEU-ENKEPHALIN AMIDE

1of4

TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS 5ACOH 6H2O TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS PORCINE YGGFLRRIRPKLK L-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS DYNORPHIN A PORCINE FRAGMENT 1-13 DYNORPHIN A(HUMAN, 1-13) DYNORPHIN A (HUMAN, 1-13) (PORCINE, RAT, BOVINE) DYNORPHIN A (HUMAN, 1-13) (PORCINE, RAT, BOVINE) 5ACOH 6H2O DYNORPHIN A (1-13) DYNORPHIN A (1-13), PORCINE DYNORPHIN 1-13 H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS-OH DYNORPHIN A (2-13) SYNTHETIC >97% OPIOID AGONIST DYNORPHIN A (1-13) SYNTHETIC >97% OPIOID AGONIST Dynorphin A (1-13) (human, porcine) Porcine dynorphin A(1-13) H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH acetate salt dynorphin A, porcine, fragment 1-13 acetate Dyn(1-13) Dynorphin A(1-13)【pig】 Dynorphin A(1-13)【rat】 Dynorphin A1-13【pig】 Dynphin A (1-13) Acetate Dynorphin (1-17), Dynorphin (1-14) Porcine dynorphin A(1-13),Dynorphin A Porcine Fragment 1-13, BR 1-13-Dynorphin A (swine) Dynorphin A (1-13) USP/EP/BP Dynorphin (1-17), Dynorphin (1-13)(net) 1-13-Dynorphin A acetate salt Dynorphin A (1-13), porcine Acetate sh-Oligopeptide-71 72957-38-1 C75H126N24O15 Dynorphins Peptides Opioid Peptides BioChemical Biochemicals and Reagents Amino Acids and Peptides Opioid receptor and opioid-like receptor peptide DynorphinsPeptides for Cell Biology Dynorphins Neuropeptides Opioid Peptides