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Agar

CAS No.
9002-18-0
Chemical Name:
Agar
Synonyms
Agar powder;Agar-Agar;MACCONKEY AGAR;gar;bengal;Gelose;VEGITONE MACCONKEY AGAR NO 1;Agar;ceylon;TC AGAR
CBNumber:
CB6704452
Molecular Formula:
C14H24O9
Molecular Weight:
336.33496
MDL Number:
MFCD00081288
MOL File:
9002-18-0.mol
Last updated:2024-03-01 17:44:47

Agar Properties

Melting point 85-95 °C
FEMA 2012 | AGAR (GELIDIUM SPP.)
storage temp. room temp
solubility H2O: 1.5% with heat
form shredded
color Brownish yellow
Odor Odorless
PH Range 5 - 7
PH 6.5-6.8 (1.5% in gel, after autoclaving)
Odor Type bland
Water Solubility SOLUBLE IN HOT WATER
Sensitive Moisture Sensitive & Hygroscopic
Merck 14,184
Stability Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference 9002-18-0(CAS DataBase Reference)
FDA 21 CFR 184.1115; 582.7115; 310.545
Substances Added to Food (formerly EAFUS) AGAR (GELIDIUM SPP.)
SCOGS (Select Committee on GRAS Substances) Agar-agar
EWG's Food Scores 1
FDA UNII GRACILARIA GRACILIS POLYSACCHARIDES (3PBT7NM2M0)
AGAR, UNSPECIFIED (89T13OHQ2B)
PLOCAMIUM CARTILAGINEUM POLYSACCHARIDES (LPT5H1B7X5)
EPA Substance Registry System Agar (9002-18-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P271-P280
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36-24/25
WGK Germany  2
RTECS  AW7950000
3
TSCA  Yes
HS Code  13023100
Toxicity LD50 orally in Rabbit: 11000 mg/kg
NFPA 704
1
1 0

Agar price More Price(96)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 70143 MacConkey Agar No 1 suitable for microbiology, NutriSelect? Plus 9002-18-0 500g $106 2024-03-01 Buy
Sigma-Aldrich 70143 MacConkey Agar No 1 suitable for microbiology, NutriSelect? Plus 9002-18-0 1kg $182 2024-03-01 Buy
Sigma-Aldrich 56763 Agar high purity, low ionic content, low gel strenght 9002-18-0 500g $543 2024-03-01 Buy
Sigma-Aldrich 12177 Agar Suitable for inclusion in culture media. 9002-18-0 1kg $275 2024-03-01 Buy
Sigma-Aldrich 1.01615 Agar extra pure, EMPROVE? ESSENTIAL Ph Eur,BP 9002-18-0 1kg $265 2024-03-01 Buy
Product number Packaging Price Buy
70143 500g $106 Buy
70143 1kg $182 Buy
56763 500g $543 Buy
12177 1kg $275 Buy
1.01615 1kg $265 Buy

Agar Chemical Properties,Uses,Production

Description

Agar is a dried, hydrophilic, colloidal polysaccharide complex extracted from the agarocytes of algae of the Rhodophyceae. The structure is believed to be a complex range of polysaccharide chains having alternating a-(1!3) and b-(1!4) linkages. There are three extremes of structure noted: namely neutral agarose; pyruvated agarose having little sulfation; and a sulfated galactan. Agar can be separated into a natural gelling fraction, agarose, and a sulfated nongelling fraction, agaropectin.
Nutrient Agar
Nutrient Agar

Chemical Properties

Agar is produced by some red algae species (Rhodophyceae), especially Gelidium and Gracilaria. Agar contains two polysaccharides - agarose (agaran) and agaropectin. Agarose consists mainly of D-galactose and the 3,6-anhydro form of L-galactose, with small amounts of D-xylose. Some of the D-galactose units are methylated at C-6. The polymer contains alternatingsegments of α(1~3) linked D-galactose units and β (1~4) linked 3,6-anhydro-L-galactose. The main chains of agaropectin are similar, but contain D-glucuronic acid and small amounts of other sugars, including sulphate esters. Agar is not attacked by microorganisms and its strong gel-forming properties make it an ideal matrix for microbial cultures.

Regulatory Status

CoE: n/a
FDA: 21 CFR 150 et. seq., 184.1115, 582.7115; 27 CFR 24.243
FDA (other): Approved for OTC use (21 CFR 310.545); HOC (1992)
JECFA: ADI: Not limited (1973)

Chemical Properties

A dried hydrophilic, colloidal polygalactoside derived from the entire plant (minus the roots) of Gelidium cartilagineum (L.) Gaillon or Gracilaria confervoides (L.) Greville. It is commercially available in bundles consisting of thin, membranous agglutinated strips or in cut, flaked granulated or powdered form. Although agar was discovered in Japan in 1658, it was introduced to Europe and the United States from China in the nineteenth century, where it was initially used as a gelatin substitute in the making of desserts. It soon became widely used as a solid bacteriological culture medium after its use by Robert Koch in his famous experiments. Its major uses in the food industry of today are in bakery products, confectionary, dairy products and canned meat and fish. It is also used in microbiology, dentistry and medicine.
The Gelidium species amansii and cartilageneum are the major sources of agar, although many species of Rhodophyceae are used. The weeds (agarophytes) used in the commercial product of agar grow from the tide line out to depths of 120 ft, and are harvested by waders along the shore at low tide, raked from small boats or picked by divers. Japan is the largest producer of agar. Because agar is soluble in hot water but relatively insoluble in cold water, it is extracted by boiling the agarophyte in water, filtering, cooling to form a gel, cutting into pieces and frozen, then thawing to free the agar from salts and other impurities that are soluble in cold water. The wet agar is repeatedly washed with cold water and finally dried. American and Japanese agar are graded according to published specifications. The high-quality American agar is divided into bacteriological, medicinal and dental grades, and the Japanese agar, into three grades and two subgrades. It is odorless or with a slight characteristic odor and mucilaginous taste. The structure of agar is not completely known. Chemically, agar is believed to be composed of 3,6-anhydro-L-galactose and D-galactopyranose residues in varying proportions.

Chemical Properties

Agar occurs as transparent, odorless, tasteless strips or as a coarse or fine powder. It may be weak yellowish-orange, yellowish-gray to pale-yellow colored, or colorless. Agar is tough when damp, brittle when dry.

Occurrence

Agar is found in several species of red marine algae in oceans around the world.

Uses

Agar is a gum obtained from red seaweeds of the genera gelidium, gracilaria, and eucheuma, class rhodophyceae. it is a mixture of the polysaccharides agarose and agaropectin. it is insoluble in cold water, slowly soluble in hot water, and soluble in boiling water, forming a gel upon cooling. the gels are characterized as being tough and brittle, setting at 32–40°c, and melting at 95°c. a rigid, tough gel can be formed at 0.5%. agar mainly functions in gel for- mation because of its range between melting and setting tempera- tures, being used in piping gels, glazes, icings, dental impression material, and microbiological plating. typical use levels are 0.1–2.0%.

Uses

Agar is the most suited solidifying agent for scientific applications that require incubation temperatures closer to human body temperature. Agar is used as a medium in bacteriology and plant biology, impression material in dentistry, biofertilizer in organic farming, and salt bridges in electrochemistry. It can be used to measure the motility and mobility of microorganism owing to the porous nature of the gel form of an agar or agarose medium.

Uses

Substitute for gelatin, isinglass, etc. in making emulsions including photographic, gels in cosmetics, and as thickening agent in foods especially. confectionaries and dairy products; in meat canning; in production of medicinal encapsulations and ointments; as dental impression mold base; as corrosion inhibitor; sizing for silks and paper; in the dyeing and printing of fabrics and textiles; in adhesives. In nutrient media for bacterial cultures.

Production Methods

Agar is obtained by freeze-drying a mucilage derived from Gelidium amansii Lamouroux, other species of the same family (Gelidiaceae), or other red algae (Rhodophyta).

Definition

agar: An extract of certain species ofred seaweeds that is used as a gellingagent in microbiological culturemedia, foodstuffs, medicines, andcosmetic creams and jellies. Nutrientagar consists of a broth made frombeef extract or blood that is gelledwith agar and used for the cultivationof bacteria, fungi, and somealgae.

General Description

Tan powder.

Air & Water Reactions

Water insoluble.

Reactivity Profile

Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. They exhibit both weak acid and weak base behavior.

Fire Hazard

Flash point data for Agar are not available. Agar is probably combustible.

Agricultural Uses

Also known as agar, the word agar-agar is of Malaysian origin. It refers to the red seaweeds belonging to genus Eucheuma, used widely in Malaysia for making a gelatinous material.
Agar is a mucilage synthesized by red algae and stored along with cellulose in the cell wall. It is a dry, amorphous and gelatine-like extract, devoid of any nonnitrogenous material from Gelidium and other agarophytes. The extract is the sulphuric acid ester of a linear galactan, soluble in hot water but insoluble in cold water. A 1.5% agar solution can form a firm gel at around 35℃ (with a melting point above 85℃), the gel being a mixture of a partially methylated neutral polysaccharide (agarose) and sulphuric acid ester (agaropectin) of a linear galactan. The gel is made under steam pressure or by boiling, and its agar content depends on the algal species, season and extraction method.
Agar is manufactured from various algae or seaweeds called agarophytes, whereas the term agaroidophyte denotes the red seaweeds that yield a substance chemically akin to an agar-like substance, but with different viscosity and gelling properties. The important agarophytes used for extraction of agar are Acanthopeltis japonica, Ahnfeltia plicata and species under the genera Gelidium, Gracilaria and Rerocladia. Other red algae are Comphylaephora, Eucheuma, Hypnea, Gigartina and Furcellaria.
Different countries use different red algae for making agar. For example, Suhria, Gelidium, Pterocladia, and Ahnfeltia are used in South Africa, the US, New Zealand and Russia respectively. Often, the alga carries the name of that country where it is used. For example, Ceylon agar (or Ceylon moss) refers to the dried red seaweed Gracilaria lichenoides found mainly in Sri Lanka, whereas the same alga found along the Indian coast bordering the Indian Ocean is called Bengal isinglass. Gracilaria verrucosa in China is known as Chinese moss, whereas in Japan, agar-agar made from Gelidium sp. is called Kanten, which means cold sky, because it was made in cold winter days or high up in the mountains.
Agar is used for many purposes - as a solidifying agent in the culture medium used for multiplication of beneficial bacteria like Azotobacter and Azospirillum during biofertilizer production, for algal growth, for canning tuna fish (in Japan), in the sizing of fabrics, etc. Various grades of agar are used as coating material for waterproofing paper and cloth, as a glue, as a cleaning medium for liquids, as a lubricant, in hot drawing of tungsten wire for electrical lamps (for which a suspension of powdered graphite in agar gel is used), for making photographic plates and films, for imparting gloss and stiffness to leather, and as an adhesive in the manufacture of plywood. Agar is even used in food products, for thickening soups, sauces, ice creams, malted milks, jellies, candies and pastries. Due to its high temperature tolerance, agar is fovored in food products. It substitutes pectin for making jellies, jams, marmalades, etc. and serves as a clarifying agent in the manufacture of wine, beer and coffee.

Pharmaceutical Applications

Agar is widely used in food applications as a stabilizing agent. In pharmaceutical applications, agar is used in a handful of oral tablet and topical formulations. It has also been investigated in a number of experimental pharmaceutical applications including as a sustained-release agent in gels, beads, microspheres, and tablets.It has also been reported to work as a disintegrant in tablets.
Agar has been used in a floating controlled-release tablet; the buoyancy in part being attributed to air entrapped in the agar gel network.It can be used as a viscosity-increasing agent in aqueous systems. Agar can also be used as a base for nonmelting, and nondisintegrating suppositories.Agar has an application as a suspending agent in pharmaceutical suspensions.

Biochem/physiol Actions

Bacteriological agar is commonly used as a culture medium for microorganism. It is useful for fermentation process. Agar-agar serves as a preservative in food processing. It also possesses various other applications such as an emulsifier, carrier, lubricant, stabilizer, laxative disintegrant in pharmaceutical and cosmetic industries. Agar-agar is also used in photographic emulsion.

Safety Profile

Mildly toxic by ingestion. When heated to decomposition it emits acrid smoke and fumes.

Safety

Agar is widely used in food applications and has been used in oral and topical pharmaceutical applications. It is generally regarded as relatively nontoxic and nonirritant when used as an excipient.
LD50 (hamster, oral): 6.1 g/kg
LD50 (mouse, oral): 16.0 g/kg
LD50 (rabbit, oral): 5.8 g/kg
LD50 (rat, oral): 11.0 g/kg

storage

Agar solutions are most stable at pH 4–10.
Agar should be stored in a cool, dry, place. Containers of this material may be hazardous when empty since they retain product residues (dust, solids).

Incompatibilities

Agar is incompatible with strong oxidizing agents. Agar is dehydrated and precipitated from solution by ethanol (95%). Tannic acid causes precipitation; electrolytes cause partial dehydration and decrease in viscosity of sols.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral tablets). Included in the Canadian List of Acceptable Non-medicinal Ingredients. Included in nonparenteral medicines licensed in the UK.

Global( 527)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yibangte Import and Export Co. , Ltd.
+86-0311-85030958 +8615532196582 lisa@yibangte.com China 2987 58
Hebei Mojin Biotechnology Co., Ltd
+86-13288715578 +86-13231137666 sales@hbmojin.com China 12409 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5960 58
Hebei Guanlang Biotechnology Co,.LTD
+8619930503252 daisy@crovellbio.com China 5966 58
Hebei Jingbo New Material Technology Co., Ltd
+8619931165850 admin@hbjingbo.cn China 1000 58
Shandong Juchuang Chemical Co., LTD
+86-18885615001 +86-18885615001 admin@juchuangchem.com China 387 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21703 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9359 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2989 55
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58

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