Fenoldopam
- CAS No.
- 67227-56-9
- Chemical Name:
- Fenoldopam
- Synonyms
- CS-1332;Corlopam;SKF-82526;FENOLDOPAM;SKF-82526-J;CORLOPAM MESYLATE;Fenoldopam, Corlopam;Fenoldopam USP/EP/BP;Fenoldopam hydrochlo;FenoldopamMesylateBase
- CBNumber:
- CB6729842
- Molecular Formula:
- C16H16ClNO3
- Molecular Weight:
- 305.76
- MDL Number:
- MFCD00865806
- MOL File:
- 67227-56-9.mol
- MSDS File:
- SDS
| Boiling point | 522.6±50.0 °C(Predicted) |
|---|---|
| Density | 1.380±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >12 mg/mL |
| pka | 8.50±0.40(Predicted) |
| form | Powder |
| color | off-white |
| CAS DataBase Reference | 67227-56-9(CAS DataBase Reference) |
| FDA UNII | INU8H2KAWG |
| ATC code | C01CA19 |
SAFETY
Risk and Safety Statements
| Hazard Codes | Xn |
|---|---|
| Risk Statements | 22-36-42/43 |
| Safety Statements | 22-26-36/37/39 |
| WGK Germany | 3 |
Fenoldopam price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 1659 | Fenoldopamhydrochloride ≥98%(HPLC) | 67227-56-9 | 10 | $195 | 2021-12-16 | Buy |
| Tocris | 1659 | Fenoldopamhydrochloride ≥98%(HPLC) | 67227-56-9 | 50 | $818 | 2021-12-16 | Buy |
| Usbiological | 011983 | Fenoldopam | 67227-56-9 | 10mg | $446 | 2021-12-16 | Buy |
| Usbiological | 011985 | Fenoldopam Hydrochloride | 67227-56-9 | 10mg | $446 | 2021-12-16 | Buy |
| AK Scientific | I745 | Fenoldopam | 67227-56-9 | 10mg | $229 | 2021-12-16 | Buy |
Fenoldopam Chemical Properties,Uses,Production
Originator
Corlopam,Pharmaforce, Inc.
Uses
dopamine receptor agonists
Uses
Dopamine D1-receptor agonist. Antihypertensive.
Uses
The dopamine receptors play important role in cognition, memory, learning, and motor control (1). These receptors have been implicated as a therapeutic target for many psychiatric and neurological disorders. Fenoldopam is a selective dopamine 1 receptor agonist with diuretic and properties (2,3).
Definition
ChEBI: Fenoldopam is a benzazepine. It has a role as a dopaminergic antagonist, a vasodilator agent, an alpha-adrenergic agonist, a dopamine agonist and an antihypertensive agent.
Manufacturing Process
2-Chloro-3,4-dimethoxyphenethylamine (1.0 g) was reacted with 0.70 g of pmethoxystyrene
oxide to give the hydroxyphenethylamine; m.p. 118.5-121°C.
This compound (2.16 g) was stirred at room temperature in 15 ml of
trifluoroacetic acid with 4 drops of conc. sulfuric acid. After purification over a
silica gel column with chloroform, 10% methanol/chloroform as eluates, was
obtained 6-chloro-7,8-dimethoxy-1-p-methoxyphenyl-2,3,4,5-tetrahydro-1H-
3-benzazepine (0.78 g), m.p. 143-145°C.
The trimethoxy product (0.87 g, 2.50 mmoles) in 25 ml of dry methylene
chloride was cooled in an ice-methanol bath and 12.5 ml (25.0 mmoles) of
boron tribromide in methylene chloride was added dropwise. After stirring for
4 hours, the mixture was cooled in an ice bath while methanol was carefully
added to give 0.37 g of 6-chloro-7,8-dihydroxy-1-p-hydroxyphenyl-2,3,4,5-
tetrahydro-1H-3-benzazepine hydrobromide, m.p. 215°C.
The base was regenerated from the hydrobromide salt using sodium carbonate solution in 85% yield. Treating the base with various acids gave the
following salts: dl-tartrate, fumarate, hydrochloride, sulfate, and the most
water soluble one, the methanesulfonate, m.p. 272°C.
brand name
Corlopam (Hospira).
Therapeutic Function
Antihypertensive
Biological Activity
Selective D 1 -like dopamine receptor partial agonist (EC 50 = 57 nM). Vasodilator in vivo and does not readily cross the blood-brain barrier. Also α 2 -adrenoceptor antagonist in vitro (K i = 15-25 nM).
Fenoldopam Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9358 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
View Lastest Price from Fenoldopam manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-11 | Fenoldopam USP/EP/BP
67227-56-9
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2020-05-10 | Fenoldopam
67227-56-9
|
US $0.00-0.00 / Kg | 1KG | 99.0% | 500 MT | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | Fenoldopam
67227-56-9
|
US $1.00 / KG | 1G | 98% | 100KG | Career Henan Chemical Co |
-
- Fenoldopam USP/EP/BP
67227-56-9
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Fenoldopam
67227-56-9
- US $0.00-0.00 / Kg
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- Fenoldopam
67227-56-9
- US $1.00 / KG
- 98%
- Career Henan Chemical Co