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4-Bromotoluene

4-Bromotoluene structure

CAS No.: 106-38-7

Chemical Name:: 4-Bromotoluene

Synonyms: 1-BROMO-4-METHYLBENZENE;P-BROMOTOLUENE;PARA BROMO TOLUENE;1-Brom-4-methylbenzol;uene;ai328596;4-BromotoL;4-Bromtoluol;p-Tolybromide;p-bromo-toluen

CBNumber:: CB6731117

Molecular Formula:: C7H7Br

Molecular Weight:: 171.03

MDL Number:: MFCD00000109

MOL File:: 106-38-7.mol

MSDS File:: SDS

Last updated:2024-02-18 17:28:16

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4-Bromotoluene Properties

Melting point	26-29 °C(lit.)
Boiling point	184 °C(lit.)
Density	1.39 g/mL at 25 °C(lit.)
refractive index	1.549
Flash point	185 °F
storage temp.	Store below +30°C.
solubility	0.11g/l insoluble
form	Crystalline Low Melting Mass
Specific Gravity	1.390
color	White
Water Solubility	<0.1 g/100 mL at 24 ºC
Merck	14,1439
BRN	1903636
Dielectric constant	5.5（58.0℃）
CAS DataBase Reference	106-38-7(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	9E349GQ7EU
NIST Chemistry Reference	Benzene, 1-bromo-4-methyl-(106-38-7)
EPA Substance Registry System	p-Bromotoluene (106-38-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS09

Signal word

Warning

Hazard statements

H332-H411

Precautionary statements

P261-P271-P273-P304+P340+P312-P391-P501

Hazard Codes

Xn,N,T

Risk Statements

22-38-51/53-36/37/38

Safety Statements

28-61-37/39-26

RIDADR

UN 3077 9/PG 3

WGK Germany

RTECS

XS7965600

TSCA

Yes

HazardClass

PackingGroup

III

HS Code

29036990

NFPA 704

	2
2		0

4-Bromotoluene price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B82200	4-Bromotoluene 98%	106-38-7	5g	$36.4	2024-03-01	Buy
Sigma-Aldrich	B82200	4-Bromotoluene 98%	106-38-7	100g	$57.2	2024-03-01	Buy
TCI Chemical	B0661	4-Bromotoluene >99.0%(GC)	106-38-7	25g	$39	2024-03-01	Buy
TCI Chemical	B0661	4-Bromotoluene >99.0%(GC)	106-38-7	100g	$89	2024-03-01	Buy
Alfa Aesar	A15843	4-Bromotoluene, 98%	106-38-7	25g	$26.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
B82200	5g	$36.4	Buy
B82200	100g	$57.2	Buy
B0661	25g	$39	Buy
B0661	100g	$89	Buy
A15843	25g	$26.65	Buy

4-Bromotoluene Chemical Properties,Uses,Production

Description

4-Bromotoluene is a p-substituted aryl bromide. As a toluene derivative, it is used as a solvent and starting material for organic synthesis and is found in paints, paint thinners, glues, and other products. 4-Bromotoluene was used in the synthesis of ketones by Cu/Pd-catalyzed decarboxylative cross-coupling reaction. It is also used in manufacturing pharmaceuticals (especially for antihypertensive like losartan, Irbesartan), pesticides and other organic compounds^1-3.

References

https://www.sigmaaldrich.com/catalog/search?term=4-Bromotoluene&interface=All&N=0&mode=match%20partialmax&lang=en&region=US&focus=product
https://bbzfrankie.wordpress.com/2013/11/21/application-of-4-bromotoluene/
https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+6015

Chemical Properties

white crystalline low melting mass, soluble in ethanol, ether and benzene, insoluble in water. toxic, harmful if swallowed, irritating to eyes, respiratory system and skin. 4-bromotoluene is a raw material of organic synthesis, which can be used as the manufacture of p-bromobenzyl, p-bromodibromobenzyl and p-bromobenzaldehyde, etc.

Uses

4-Bromotoluene was used in the synthesis of ketones by Cu/Pd-catalyzed decarboxylative cross-coupling reaction. 4-Bromotoluene undergoes Heck reaction with styrene in the presence of in situ generated palladium complexes of phosphine-functionalized N-heterocyclic carbene ligands.

Preparation

4-Bromotoluene is prepared by diazotization and replacement of p-toluidine. First, add aqueous sulfuric acid solution to crushed p-toluidine while hot, cool to 5°C, and slowly add aqueous sodium nitrite solution until the starch potassium iodide test paper turns blue. Then add a small amount of urea to destroy the excess of sodium nitrite. Then add the synthesized cuprous bromide to hydrobromic acid, heat it to boiling, then slowly add the above diazo salt and distill it until no oil-like substance comes out. Wash, dry, filter, distill at atmospheric pressure and collect 183-185℃ fraction to obtain 4-Bromotoluene.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 1, p. 136, 1941
Tetrahedron, 64, p. 4999, 2008 DOI: 10.1016/j.tet.2008.03.085

General Description

Crystals, clear pale yellow liquid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4-Bromotoluene is incompatible with strong oxidizing agents.

Fire Hazard

4-Bromotoluene is combustible.

Safety Profile

Moderately toxic by inhalation and intraperitoneal routes. When heated to decomposition it emits toxic vapors of Br-.

Purification Methods

Crystallise it from EtOH [Taylor & Stewart J Am Chem Soc 108 6977 1986]. [Beilstein 5 IV 827.]

4-Bromotoluene Preparation Products And Raw materials

Raw materials

PotassiuM iodide starch pa Sodium molybdate dihydrate Sodium bromide Copper shavings Cuprous bromide

Copper(II) sulfate p-Toluidine Phenetole

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Preparation Products

(S)-(-)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL BIS(P-TOLYL)PHOSPHINE OXIDE 4-((N,N-DIMETHYLAMINO)METHYL)PHENYLBORONIC ACID PINACOL ESTER HYDROCHLORIDE 4-Bromobenzoic acid (S)-7,7'-Bis[di(p-methylphenyl)phosphino]-1,1'-spirobiindane ,97%

TRI-P-TOLYLPHOSPHINE (R)-(+)-7,7'-BIS[DI(4-METHYLPHENYL)PHOSPHINO]-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE (4-PHENYLAMINOCARBONYLPHENYL)BORONIC ACID 2-(4-Methylphenyl)pyridine 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl

TERT-BUTYL 4-(4-FORMYLBENZYL)PIPERAZINE-1-CARBOXYLATE (R)-(+)-TolBINAP 4-Bromobenzyl bromide 4-Bromobenzaldehyde 4′-Methylbiphenyl-2-carboxylic acid methyl ester

4-(METHOXYCARBONYL)PHENYLBORONIC ACID 4-N-BUTYLTOLUENE 3-(4-METHYLPHENYL)BENZALDEHYDE 2-Bromo-4-chlorotoluene 1,2-DI(P-TOLYL)ETHANE

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4-Bromotoluene Suppliers

Global( 452)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12453	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7534	58
Springchem New Material Technology Co.,Limited	+86-021-62885108 +8613917661608	info@spring-chem.com	China	2068	57
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15371	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55
Speranza Chemical Co., Ltd.	+86-86-075521030354 +8618688942810	sophieliu@speranzachem.com	China	723	55
Zjartschem	+86-571-8723 8903 jocelynpan@zjarts.com	jocelynpan@zjarts.com	CHINA	993	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Springchem New Material Technology Co.,Limited	57
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
Speranza Chemical Co., Ltd.	55
Zjartschem	58

View Lastest Price from 4-Bromotoluene manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-23	4-Bromotoluene 106-38-7	US $22200.00-21600.00 / Tons	100Tons	99.99%	200Tons	Hebei Dangtong Import and export Co LTD
2024-04-10	4-Bromotoluene 106-38-7	US $0.00 / kg	1kg	99%	500KG	Shanghai Joiny Pharmaceutical Co.,LTD
2023-12-26	4-Bromotoluene 106-38-7	US $100.00-1.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

4-Bromotoluene
106-38-7
US $22200.00-21600.00 / Tons
99.99%
Hebei Dangtong Import and export Co LTD

4-Bromotoluene
106-38-7
US $0.00 / kg
99%
Shanghai Joiny Pharmaceutical Co.,LTD

4-Bromotoluene
106-38-7
US $100.00-1.00 / KG
99%
Henan Fengda Chemical Co., Ltd

4-Bromotoluene Spectrum

4-Bromotoluene(106-38-7)MS 4-Bromotoluene(106-38-7)¹HNMR 4-Bromotoluene(106-38-7)¹³CNMR 4-Bromotoluene(106-38-7)IR1 4-Bromotoluene(106-38-7)IR2 4-Bromotoluene(106-38-7)IR3 4-Bromotoluene(106-38-7)Raman

106-38-7(4-Bromotoluene)Related Search:

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4-Chlorotoluene Kresoxim-methyl Xylene Dimidium bromide p-Toluenesulfonamide

Sodium bromate Rocuronium bromide o-Xylene

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1-bromo-4-methyl-benzen 1-Methyl-4-bromobenzene ai328596 benzene,1-bromo-4-methyl- p-bromo-toluen p-Tolybromide Toluene, p-bromo- toluene,4-bromo- Toluene,p-bromo- 4-BROMO-1-METHYLBENZENE 4-BROMOTOLUENE The broMine toluene 4-Bromo-1-methybezene 4-bromo-toluen 4-Bromtoluol 4-Methylbromobenzene 4-Methylphenyl bromide 4-methylphenylbromide 4-tolylbromide 4-Methyl-1-bromobenzene p-Bromo Toluene 4-Bromo Toluene 4-BroMotoluene, 99% 100ML P-TOLYL BROMIDE p-methylphenyl bromide p-Methylbromobenzene AKOS BBS-00004360 4-BROMOTOLUENE FOR SYNTHESIS 250 G 4-BROMOTOLUENE FOR SYNTHESIS 100 G 4-BromotoL uene 4-Bromotoluene > 4-Bromotoluene ISO 9001：2015 REACH 4-Bromotoluene extrapure, 99% 1-Brom-4-methylbenzol P-BROMOTOLUENE PARA BROMO TOLUENE 1-BROMO-4-METHYLBENZENE 4-Bromo Toluence 4-BROMO TOLUENE / PARA BROMO TOLUENE 106-38-7 106-37-8 BrC6H4CH3 Halogenated Hydrocarbons Organic Building Blocks ARYL HALIDE Aryl C7 Building Blocks 4-Alkylbromobenzenes (Building Blocks for Liquid Crystals) Building Blocks for Liquid Crystals alkyl bromide Building Blocks Chemical Synthesis Halogenated Hydrocarbons Organic Building Blocks Intermediates Aromatic Hydrocarbons (substituted) & Derivatives Organics